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Tbio
ATP5S
ATP synthase subunit s, mitochondrial

Protein Summary
Description
Involved in regulation of mitochondrial membrane ATP synthase. Necessary for H(+) conduction of ATP synthase. Facilitates energy-driven catalysis of ATP synthesis by blocking a proton leak through an alternative proton exit pathway (By similarity). This gene encodes a subunit of mitochondrial ATP synthase. Mitochondrial ATP synthase catalyzes ATP synthesis, utilizing an electrochemical gradient of protons across the inner membrane during oxidative phosphorylation. ATP synthase is composed of two linked multi-subunit complexes: the soluble catalytic core, F1, and the membrane-spanning component, Fo, comprising the proton channel. This gene encodes the subunit s, also known as factor B, of the proton channel. This subunit is necessary for the energy transduction activity of the ATP synthase complexes. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Jul 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000245448
  • ENSP00000245448
  • ENSG00000125375
  • ENST00000311459
  • ENSP00000308334
  • ENST00000426751
  • ENSP00000389246

Symbol
  • ATPW
  • FB
  • ATPW
  • ATP5S
  • HSU79253
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
disease perturbation
0.97
histone modification site profile
0.94
virus perturbation
0.85
transcription factor perturbation
0.8
biological process
0.74


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 5.69   (req: < 5)
Gene RIFs: 2   (req: <= 3)
Antibodies: 138   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 5.69   (req: >= 5)
Gene RIFs: 2   (req: > 3)
Antibodies: 138   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 5
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (100)
CCL4
Tbio
Novelty:  0.00069278
p_int:  0.999999999
p_ni:  1e-9
Score:  0.379
Data Source:  BioPlex,STRINGDB
SPINK2
Tdark
Family:  Enzyme
Novelty:  0.06832697
p_int:  0.999981921
p_ni:  0.000016838
p_wrong:  0.000001241
Score:  0.202
Data Source:  BioPlex,STRINGDB
TRMT2A
Tbio
Family:  Enzyme
Novelty:  0.15277091
p_int:  0.999142624
p_ni:  0.000036251
p_wrong:  0.000821124
Score:  0.19
Data Source:  BioPlex,STRINGDB
MFSD4A
Tdark
Novelty:  0.62186415
p_int:  0.998168142
p_ni:  0.000257407
p_wrong:  0.001574451
Score:  0.228
Data Source:  BioPlex,STRINGDB
ATP5PB
Tbio
Family:  Enzyme
Novelty:  0.07345384
Score:  0.999
Data Source:  STRINGDB
ATP5MF
Tbio
Family:  Enzyme
Novelty:  0.00707678
Score:  0.975
Data Source:  STRINGDB
ATP5PD
Tbio
Family:  Enzyme
Novelty:  0.0730514
Score:  0.972
Data Source:  STRINGDB
ATP5MC3
Tdark
Family:  Enzyme
Novelty:  0.04850603
Score:  0.97
Data Source:  STRINGDB
ATP5ME
Tbio
Family:  Enzyme
Novelty:  0.12559724
Score:  0.966
Data Source:  STRINGDB
ATP5MC1
Tbio
Family:  Enzyme
Novelty:  0.03538978
Score:  0.955
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (2)
Find Similar Targets
Items per page:
1 – 2 of 2
Data Source
Name
Explore in Pharos
Explore in Source
WikiPathways
Electron Transport Chain (OXPHOS system in mitochondria)
WikiPathways
Oxidative phosphorylation
Name
Explore in Pharos
Explore in Source
Electron Transport Chain (OXPHOS system in mitochondria)
Oxidative phosphorylation
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (9)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
glomerular filtration rate
6
1
6
5.5
82.6
systolic blood pressure
1
1
1
79.7
serum alanine aminotransferase measurement
1
1
1
79.5
sex hormone-binding globulin measurement
2
1
2
56.3
mean corpuscular hemoglobin concentration
1
1
1
48.8
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
glomerular filtration rate
6
5.5
82.6
systolic blood pressure
1
79.7
serum alanine aminotransferase measurement
1
79.5
sex hormone-binding globulin measurement
2
56.3
mean corpuscular hemoglobin concentration
1
48.8
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (8)
1 – 5 of 8
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Mouse
MGI:1915305
68055
Rat
RGD:1359208
362749
Dog
ATP synthase, H+ transporting, mitochondrial Fo complex subunit s (factor B)
490683
Horse
ATP synthase, H+ transporting, mitochondrial Fo complex subunit s
VGNC:49187
100066369
Cow
ATP synthase, H+ transporting, mitochondrial Fo complex subunit s
VGNC:54625
493709
Species
Name
OMA
EggNOG
Inparanoid
Mouse
Rat
Dog
ATP synthase, H+ transporting, mitochondrial Fo complex subunit s (factor B)
Horse
ATP synthase, H+ transporting, mitochondrial Fo complex subunit s
Cow
ATP synthase, H+ transporting, mitochondrial Fo complex subunit s
Publication Statistics
PubMed Score 5.69
PubMed score by year
PubTator Score 0.08
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title