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Tbio
ARL6IP1
ADP-ribosylation factor-like protein 6-interacting protein 1

Protein Summary
Description
Positively regulates SLC1A1/EAAC1-mediated glutamate transport by increasing its affinity for glutamate in a PKC activity-dependent manner. Promotes the catalytic efficiency of SLC1A1/EAAC1 probably by reducing its interaction with ARL6IP5, a negative regulator of SLC1A1/EAAC1-mediated glutamate transport (By similarity). Plays a role in the formation and stabilization of endoplasmic reticulum tubules (PubMed:24262037). Negatively regulates apoptosis, possibly by modulating the activity of caspase-9 (CASP9). Inhibits cleavage of CASP9-dependent substrates and downstream markers of apoptosis but not CASP9 itself (PubMed:12754298). May be involved in protein transport, membrane trafficking, or cell signaling during hematopoietic maturation (PubMed:10995579). This gene belongs to the ARL6ip family and encodes a transmembrane protein that is predominantly localized to intracytoplasmic membranes. It is highly expressed in early myeloid progenitor cells and thought to be involved in protein ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000304414
  • ENSP00000306788
  • ENSG00000170540
  • ENST00000546206
  • ENSP00000440048

Symbol
  • ARL6IP
  • ARMER
  • KIAA0069
  • AIP1
  • ARMER
  • SPG61
  • ARL6IP
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
transcription factor perturbation
1
kinase perturbation
0.98
transcription factor binding site profile
0.93
virus perturbation
0.9
disease perturbation
0.87


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 17.16   (req: < 5)
Gene RIFs: 4   (req: <= 3)
Antibodies: 264   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 17.16   (req: >= 5)
Gene RIFs: 4   (req: > 3)
Antibodies: 264   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 8
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (51)
RTN4
Tbio
Novelty:  0.00080371
p_int:  0.999994878
p_ni:  0.000005122
Score:  0.631
Data Source:  BioPlex,STRINGDB
ATP2B2
Tbio
Family:  Transporter
Novelty:  0.007782
p_int:  0.998613125
p_ni:  0.000811608
p_wrong:  0.000575267
Data Source:  BioPlex
IPPK
Tbio
Family:  Enzyme
Novelty:  0.02169701
p_int:  0.997804403
p_ni:  0.001925091
p_wrong:  0.000270505
Score:  0.18
Data Source:  BioPlex,STRINGDB
FPR2
Tchem
Family:  GPCR
Novelty:  0.00228744
p_int:  0.996249393
p_ni:  0.000066705
p_wrong:  0.003683902
Score:  0.526
Data Source:  BioPlex,STRINGDB
TSPAN31
Tbio
Novelty:  0.13580467
p_int:  0.953624935
p_ni:  0.000032603
p_wrong:  0.046342462
Data Source:  BioPlex
SLC2A9
Tbio
Family:  Transporter
Novelty:  0.00683926
p_int:  0.797611999
p_ni:  0.017782416
p_wrong:  0.184605585
Data Source:  BioPlex
ARL6
Tbio
Family:  Enzyme
Novelty:  0.25184759
Score:  0.808
Data Source:  STRINGDB
LYSMD3
Tdark
Novelty:  1.09261968
Score:  0.761
Data Source:  STRINGDB
ARL6IP5
Tbio
Novelty:  0.00871985
Score:  0.718
Data Source:  STRINGDB
LSM8
Tbio
Novelty:  0.08782322
Score:  0.682
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (0)
No pathways found
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (2)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
heel bone mineral density
1
1
1
35
mean platelet volume
1
1
1
6.5
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
heel bone mineral density
1
35
mean platelet volume
1
6.5
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (13)
1 – 5 of 13
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
ADP ribosylation factor like GTPase 6 interacting protein 1
VGNC:13663
453960
Macaque
ADP-ribosylation factor-like protein 6-interacting protein 1
713332
Mouse
MGI:1858943
54208
Rat
RGD:735205
293551
Dog
ADP-ribosylation factor-like protein 6-interacting protein 1
100856583
Species
Name
OMA
EggNOG
Inparanoid
Chimp
ADP ribosylation factor like GTPase 6 interacting protein 1
Macaque
ADP-ribosylation factor-like protein 6-interacting protein 1
Mouse
Rat
Dog
ADP-ribosylation factor-like protein 6-interacting protein 1
Publication Statistics
PubMed Score 17.16
PubMed score by year
PubTator Score 11.05
PubTator score by year
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Related Publications
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PMID
Year
Title