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Tdark
ANKRD13B
Ankyrin repeat domain-containing protein 13B

Protein Summary
Description
Ubiquitin-binding protein that specifically recognizes and binds 'Lys-63'-linked ubiquitin. Does not bind 'Lys-48'-linked ubiquitin. Positively regulates the internalization of ligand-activated EGFR by binding to the Ub moiety of ubiquitinated EGFR at the cell membrane.
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000394859
  • ENSP00000378328
  • ENSG00000198720
  • ENST00000488766
  • ENSP00000431958
  • ENST00000614878
  • ENSP00000481530
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
cell type or tissue
0.8
transcription factor
0.71
tissue sample
0.63
transcription factor binding site profile
0.62
cell line
0.61


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 0.32   (req: < 5)
Gene RIFs: 1   (req: <= 3)
Antibodies: 56   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 0.32   (req: >= 5)
Gene RIFs: 1   (req: > 3)
Antibodies: 56   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Term: 0
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (8)
GNAI3
Tbio
Novelty:  0.03484857
p_int:  0.99999845
p_ni:  4e-9
p_wrong:  0.000001546
Score:  0.316
Data Source:  BioPlex,STRINGDB
LRRC37B
Tdark
Novelty:  0.60307987
Score:  0.558
Data Source:  STRINGDB
FAM208A
Tbio
Novelty:  0.17789689
Score:  0.556
Data Source:  STRINGDB
CCDC91
Tbio
Novelty:  0.11171935
Score:  0.479
Data Source:  STRINGDB
ZNFX1
Tdark
Novelty:  0.06228436
Score:  0.454
Data Source:  STRINGDB
ZDHHC24
Tdark
Family:  Enzyme
Novelty:  7.07788209
Score:  0.446
Data Source:  STRINGDB
ZBTB24
Tbio
Family:  TF
Novelty:  0.041401
Score:  0.441
Data Source:  STRINGDB
TTC7A
Tbio
Novelty:  0.0282236
Score:  0.422
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (0)
No pathways found
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (18)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
mean platelet volume
1
1
1
87.7
platelet count
1
1
1
85.9
heel bone mineral density
2
1
2
82.5
lymphocyte count
2
2
2
82.4
BMI-adjusted waist-hip ratio
2
2
3
74
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
mean platelet volume
1
87.7
platelet count
1
85.9
heel bone mineral density
2
82.5
lymphocyte count
2
82.4
BMI-adjusted waist-hip ratio
3
74
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (12)
1 – 5 of 12
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
ankyrin repeat domain 13B
VGNC:6337
736022
Macaque
ankyrin repeat domain 13B
711735
Mouse
MGI:2144501
268445
Rat
RGD:1564005
360575
Dog
ankyrin repeat domain 13B
VGNC:37885
491181
Species
Name
OMA
EggNOG
Inparanoid
Chimp
ankyrin repeat domain 13B
Macaque
ankyrin repeat domain 13B
Mouse
Rat
Dog
ankyrin repeat domain 13B
Publication Statistics
PubMed Score 0.32
PubMed score by year
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Related Publications
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0 of 0
PMID
Year
Title