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Tdark
ANKIB1
Ankyrin repeat and IBR domain-containing protein 1

Protein Summary
Description
Might act as an E3 ubiquitin-protein ligase, or as part of E3 complex, which accepts ubiquitin from specific E2 ubiquitin-conjugating enzymes and then transfers it to substrates.
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000265742
  • ENSP00000265742
  • ENSG00000001629

Symbol
  • KIAA1386
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
transcription factor perturbation
0.94
histone modification site profile
0.9
protein domain
0.85
ligand (protein) perturbation
0.83
virus perturbation
0.76


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 3.67   (req: < 5)
Gene RIFs: 1   (req: <= 3)
Antibodies: 24   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 3.67   (req: >= 5)
Gene RIFs: 1   (req: > 3)
Antibodies: 24   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 6
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (51)
CWF19L2
Tdark
Novelty:  0.80210985
Score:  0.819
Data Source:  STRINGDB
RNF216
Tbio
Family:  Enzyme
Novelty:  0.03521574
Score:  0.819
Data Source:  STRINGDB
SEC14L3
Tbio
Novelty:  0.15067161
Score:  0.602
Data Source:  STRINGDB
STK35
Tchem
Family:  Kinase
Novelty:  0.19556072
Score:  0.565
Data Source:  STRINGDB
RBM48
Tdark
Novelty:  0.50797247
Score:  0.558
Data Source:  STRINGDB
STAU2
Tbio
Novelty:  0.03802876
Score:  0.55
Data Source:  STRINGDB
GABARAPL1
Tbio
Novelty:  0.00212657
Score:  0.527
Data Source:  STRINGDB
KDM1B
Tbio
Family:  Epigenetic
Novelty:  0.02174039
Score:  0.511
Data Source:  STRINGDB
DYNLRB2
Tbio
Novelty:  0.1714161
Score:  0.511
Data Source:  STRINGDB
FAM133B
Tdark
Novelty:  0.56033333
Score:  0.508
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (0)
No pathways found
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (5)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
hematocrit
2
2
2
70.5
hemoglobin measurement
1
1
1
39.7
BMI-adjusted hip circumference
1
1
1
39.7
brain measurement
1
1
0
6.8
9.9
lymphocyte count
1
1
1
9.5
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
hematocrit
2
70.5
hemoglobin measurement
1
39.7
BMI-adjusted hip circumference
1
39.7
brain measurement
0
6.8
9.9
lymphocyte count
1
9.5
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (12)
1 – 5 of 12
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
ankyrin repeat and IBR domain containing 1
VGNC:4258
463530
Macaque
ankyrin repeat and IBR domain containing 1
703273
Mouse
MGI:1918047
70797
Rat
RGD:1597088
368062
Dog
ankyrin repeat and IBR domain containing 1
VGNC:37873
475226
Species
Name
OMA
EggNOG
Inparanoid
Chimp
ankyrin repeat and IBR domain containing 1
Macaque
ankyrin repeat and IBR domain containing 1
Mouse
Rat
Dog
ankyrin repeat and IBR domain containing 1
Publication Statistics
PubMed Score 3.67
PubMed score by year
PubTator Score 0.25
PubTator score by year
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Related Publications
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PMID
Year
Title