ibandronic acid
Aminobisphosphonate that is a potent inhibitor of BONE RESORPTION. It is used in the treatment of HYPERCALCEMIA associated with malignancy, for the prevention of fracture and bone complications in patients with breast cancer and bone metastases, and for the treatment and prevention of POSTMENOPAUSAL OSTEOPOROSIS.
Ligand Summary
Target Activities
FDPS
Farnesyl pyrophosphate synthase
10 Activities
Items per page:
1 – 10 of 10
Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) | ||
|---|---|---|---|---|---|---|
Ki | 6.71 | |||||
- | 5.13 | |||||
Ki | 8.44 | J. Med. Chem., (2008) 51:7:2187 | ||||
IC50 | 7.7 | J. Med. Chem., (2002) 45:11:2185 | ||||
IC50 | 7.59 | J. Med. Chem., (2008) 51:7:2187 | ||||
Ki | 7.34 | J. Med. Chem., (2003) 46:24:5171 | ||||
Ki | 6.71 | J. Med. Chem., (2008) 51:7:2187 | ||||
IC50 | 6.32 | J. Med. Chem., (2003) 46:24:5171 | ||||
IC50 | 6.32 | J. Med. Chem., (2003) 46:24:5171 | ||||
Ki | 8.44 | INHIBITOR | ||||
FDFT1
Squalene synthase
1 Activities
Items per page:
1 – 1 of 1
Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) | ||
|---|---|---|---|---|---|---|
IC50 | 6.19 | |||||