Pharos : Ligand Details

Target Activities

Explore Associated and Predicted Targets

MELK

Tchem

Maternal embryonic leucine zipper kinase

5 Activities

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1 – 5 of 5

Activity Type	Activity Value -log(M)	Activity Reference	Publications (PubMed IDs)
IC50	9.4	None, (2015) None:None:None

IC50	9.39	MedChemComm, (2017) 8:1:73

IC50	8.96	None, (2015) None:None:None

Kd	7.82	Bioorg Med Chem, (2020) 28:1:115193	31757680

Kd	7.54	Science, (2017) 358:6367:None	29191878

DYRK1A

Tchem

Dual specificity tyrosine-phosphorylation-regulated kinase 1A

3 Activities

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1 – 3 of 3

Activity Type	Activity Value -log(M)	Activity Reference	Publications (PubMed IDs)
Kd	9.92	Bioorg Med Chem, (2020) 28:1:115193	31757680

EC50	8.3	Bioorg Med Chem, (2020) 28:1:115193	31757680

Kd	8	Science, (2017) 358:6367:None	29191878

PRKAG2

Tchem

5'-AMP-activated protein kinase subunit gamma-2

1 Activities

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1 – 1 of 1

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)
Kd	6.68		Science, (2017) 358:6367:None	29191878

PIM1

Tchem

Serine/threonine-protein kinase pim-1

1 Activities

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1 – 1 of 1

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)
Kd	7.85		Science, (2017) 358:6367:None	29191878

STK10

Tchem

Serine/threonine-protein kinase 10

1 Activities

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1 – 1 of 1

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)
Kd	7.85		Science, (2017) 358:6367:None	29191878

CSNK2A2

Tchem

Casein kinase II subunit alpha'

1 Activities

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1 – 1 of 1

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)
Kd	8		Science, (2017) 358:6367:None	29191878

CLK1

Tchem

Dual specificity protein kinase CLK1

1 Activities

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1 – 1 of 1

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)
Kd	7.96		Science, (2017) 358:6367:None	29191878

GAK

Tchem

Cyclin-G-associated kinase

1 Activities

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1 – 1 of 1

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)
Kd	8.3		Science, (2017) 358:6367:None	29191878

EPHA7

Tchem

Ephrin type-A receptor 7

1 Activities

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1 – 1 of 1

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)
Kd	7.8		Science, (2017) 358:6367:None	29191878

RIPK2

Tchem

Receptor-interacting serine/threonine-protein kinase 2

1 Activities

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1 – 1 of 1

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)
Kd	8.3		Science, (2017) 358:6367:None	29191878

IRAK3

Tchem

Interleukin-1 receptor-associated kinase 3

1 Activities

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1 – 1 of 1

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)
Kd	7.92		Science, (2017) 358:6367:None	29191878

BCR

Tclin

Breakpoint cluster region protein

1 Activities

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1 – 1 of 1

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)
Kd	7.85		Science, (2017) 358:6367:None	29191878

TAOK1

Tchem

Serine/threonine-protein kinase TAO1

1 Activities

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1 – 1 of 1

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)
Kd	7.77		Science, (2017) 358:6367:None	29191878

NLK

Tchem

Serine/threonine-protein kinase NLK

1 Activities

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1 – 1 of 1

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)
Kd	7.62		Science, (2017) 358:6367:None	29191878

BMPR1B

Tchem

Bone morphogenetic protein receptor type-1B

1 Activities

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1 – 1 of 1

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)
Kd	8.7		Science, (2017) 358:6367:None	29191878

TAOK3

Tchem

Serine/threonine-protein kinase TAO3

1 Activities

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1 – 1 of 1

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)
Kd	7.68		Science, (2017) 358:6367:None	29191878

TAOK2

Tchem

Serine/threonine-protein kinase TAO2

1 Activities

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1 – 1 of 1

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)
Kd	8		Science, (2017) 358:6367:None	29191878

LATS1

Tchem

Serine/threonine-protein kinase LATS1

1 Activities

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1 – 1 of 1

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)
Kd	7.85		Science, (2017) 358:6367:None	29191878

PIP4K2C

Tchem

Phosphatidylinositol 5-phosphate 4-kinase type-2 gamma

1 Activities

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Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)
Kd	8.52		Science, (2017) 358:6367:None	29191878

DHX30

Tchem

ATP-dependent RNA helicase DHX30

1 Activities

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1 – 1 of 1

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)
Kd	8.22		Science, (2017) 358:6367:None	29191878

Q6ZSR9

Tchem

Uncharacterized protein FLJ45252

1 Activities

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1 – 1 of 1

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)
Kd	6.81		Science, (2017) 358:6367:None	29191878

RET

Tclin

Proto-oncogene tyrosine-protein kinase receptor Ret

1 Activities

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1 – 1 of 1

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)
Kd	7.55		Science, (2017) 358:6367:None	29191878