| Tbio | E3 ubiquitin-protein ligase ZNRF1 |
E3 ubiquitin-protein ligase that mediates the ubiquitination of AKT1 and GLUL, thereby playing a role in neuron cells differentiation. Plays a role in the establishment and maintenance of neuronal transmission and plasticity. Regulates Schwann cells differentiation by mediating ubiquitination of GLUL. Promotes neurodegeneration by mediating 'Lys-48'-linked polyubiquitination and subsequent degradation of AKT1 in axons: degradation of AKT1 prevents AKT1-mediated phosphorylation of GSK3B, leading to GSK3B activation and phosphorylation of DPYSL2/CRMP2 followed by destabilization of microtubule assembly in axons (Probable).
This gene encodes an E3 ubiquitin-protein ligase that plays a role in neural-cell differentiation. Overexpression of this gene causes neurite-like elongation. The encoded protein contains both a zinc finger and a RING finger motif and is localized in the endosome/lysosome compartment, indicating that it may be involved in ubiquitin-mediated protein modification, and in synaptic vessicle membranes in neurons. [provided by RefSeq, Feb 2012]
This gene encodes an E3 ubiquitin-protein ligase that plays a role in neural-cell differentiation. Overexpression of this gene causes neurite-like elongation. The encoded protein contains both a zinc finger and a RING finger motif and is localized in the endosome/lysosome compartment, indicating that it may be involved in ubiquitin-mediated protein modification, and in synaptic vessicle membranes in neurons. [provided by RefSeq, Feb 2012]
Comments
| Disease | Target Count | P-value |
|---|---|---|
| ovarian cancer | 8520 | 7.5e-08 |
| osteosarcoma | 7950 | 2.6e-05 |
| tuberculosis and treatment for 3 months | 179 | 3.6e-05 |
| intraductal papillary-mucinous adenoma (IPMA) | 2955 | 2.6e-04 |
| group 4 medulloblastoma | 1855 | 1.5e-03 |
| medulloblastoma, large-cell | 6241 | 1.6e-03 |
| intraductal papillary-mucinous neoplasm (IPMN) | 3291 | 3.0e-03 |
| glioblastoma | 5792 | 3.1e-03 |
| astrocytic glioma | 2597 | 3.9e-03 |
| ependymoma | 4679 | 1.0e-02 |
| oligodendroglioma | 2850 | 2.5e-02 |
| spina bifida | 1074 | 4.8e-02 |
| Disease | Target Count | Z-score | Confidence |
|---|---|---|---|
| Adult acute lymphocytic leukemia | 1 | 4.198 | 2.1 |
| Disease | log2 FC | p |
|---|---|---|
| astrocytic glioma | -1.600 | 3.9e-03 |
| ependymoma | -1.900 | 1.0e-02 |
| glioblastoma | -1.100 | 3.1e-03 |
| group 4 medulloblastoma | 1.100 | 1.5e-03 |
| intraductal papillary-mucinous adenoma (... | 1.300 | 2.6e-04 |
| intraductal papillary-mucinous neoplasm ... | 1.400 | 3.0e-03 |
| medulloblastoma, large-cell | -1.700 | 1.6e-03 |
| oligodendroglioma | -1.100 | 2.5e-02 |
| osteosarcoma | -2.074 | 2.6e-05 |
| ovarian cancer | 2.800 | 7.5e-08 |
| spina bifida | -1.780 | 4.8e-02 |
| tuberculosis and treatment for 3 months | -1.100 | 3.6e-05 |
