1. Home
  2. Targets
  3. transcription factor
  4. zinc finger transcription factor
  5. KRAB box transcription factor
  6. Zinc finger protein 91

Tbio Zinc finger protein 91

Transcription factor specifically required to repress SINE-VNTR-Alu (SVA) retrotransposons: recognizes and binds SVA sequences and represses their expression by recruiting a repressive complex containing TRIM28/KAP1 (PubMed:25274305). May also bind the promoter of the FCGR2B gene, leading to repress its expression; however, additional evidences are required to confirm this result in vivo (PubMed:11470777).

The ZNF91 gene encodes a zinc finger protein of the KRAB (Kruppel-associated box) subfamily (Bellefroid et al., 1991, 1993 [PubMed 2023909] [PubMed 8467795]).[supplied by OMIM, May 2010]

 Comments

Property Summary

NCBI Gene PubMed Count 10
PubMed Score 10.77
PubTator Score 13.14

Knowledge Summary

Patent

No data available

TINX Plot

  Disease (2)

Disease Target Count Z-score Confidence
Carcinoma 2147 0.0 1.0

Expression

  Differential Expression (24)

Disease log2 FC p
gastric cancer 1.200 1.3e-03
hepatocellular carcinoma 1.500 1.8e-05
Waldenstrons macroglobulinemia 1.038 2.2e-02
malignant mesothelioma -3.900 7.0e-09
osteosarcoma 2.580 1.1e-05
posterior fossa group A ependymoma -1.300 3.8e-07
glioblastoma -1.600 4.9e-05
astrocytoma -2.100 4.2e-03
medulloblastoma, large-cell -1.400 8.9e-06
fascioscapulohumeral muscular dystrophy -1.155 1.8e-04
non-small cell lung cancer -1.099 1.9e-06
intraductal papillary-mucinous adenoma (... 1.100 3.4e-02
interstitial cystitis -1.700 1.9e-03
adult high grade glioma -1.600 1.2e-03
group 4 medulloblastoma 1.100 1.1e-02
pilocytic astrocytoma -1.100 6.9e-04
primary Sjogren syndrome 1.100 9.6e-04
psoriasis -1.400 1.7e-24
invasive ductal carcinoma -1.441 2.8e-03
spina bifida -2.622 4.0e-02
ductal carcinoma in situ 1.100 7.6e-03
ulcerative colitis -1.600 3.6e-08
ovarian cancer 2.000 2.8e-05
dermatomyositis -1.200 2.0e-02

Synonym

Accession Q05481 A8K5E1 B7Z6G6
Symbols HPF7
HTF10

Gene

ZNF91

PANTHER Protein Class (3)

  Ortholog (1)

Species Source Disease
Chimp OMA EggNOG

 UniProt Keyword (13)

See all...

 GO Function (3)

 GO Component (1)

 GO Process (3)

 Compartment GO Term (10)

 HCA RNA Cell Line (56)

See all...

Gene RIF (1)

PMID Text
19240061 Observational study of gene-disease association. (HuGE Navigator)

AA Sequence 

MPGTPGSLEMGLLTFRDVAIEFSPEEWQCLDTAQQNLYRNVMLENYRNLAFLGIALSKPDLITYLEQGKE      1 - 70
PWNMKQHEMVDEPTGICPHFPQDFWPEQSMEDSFQKVLLRKYEKCGHENLQLRKGCKSVDECKVHKEGYN     71 - 140
KLNQCLTTAQSKVFQCGKYLKVFYKFLNSNRHTIRHTGKKCFKCKKCVKSFCIRLHKTQHKCVYITEKSC    141 - 210
KCKECEKTFHWSSTLTNHKEIHTEDKPYKCEECGKAFKQLSTLTTHKIICAKEKIYKCEECGKAFLWSST    211 - 280
LTRHKRIHTGEKPYKCEECGKAFSHSSTLAKHKRIHTGEKPYKCEECGKAFSRSSTLAKHKRIHTGEKPY    281 - 350
KCKECGKAFSNSSTLANHKITHTEEKPYKCKECDKAFKRLSTLTKHKIIHAGEKLYKCEECGKAFNRSSN    351 - 420
LTIHKFIHTGEKPYKCEECGKAFNWSSSLTKHKRFHTREKPFKCKECGKAFIWSSTLTRHKRIHTGEKPY    421 - 490
KCEECGKAFRQSSTLTKHKIIHTGEKPYKFEECGKAFRQSLTLNKHKIIHSREKPYKCKECGKAFKQFST    491 - 560
LTTHKIIHAGKKLYKCEECGKAFNHSSSLSTHKIIHTGEKSYKCEECGKAFLWSSTLRRHKRIHTGEKPY    561 - 630
KCEECGKAFSHSSALAKHKRIHTGEKPYKCKECGKAFSNSSTLANHKITHTEEKPYKCKECDKTFKRLST    631 - 700
LTKHKIIHAGEKLYKCEECGKAFNRSSNLTIHKFIHTGEKPYKCEECGKAFNWSSSLTKHKRIHTREKPF    701 - 770
KCKECGKAFIWSSTLTRHKRIHTGEKPYKCEECGKAFSRSSTLTKHKTIHTGEKPYKCKECGKAFKHSSA    771 - 840
LAKHKIIHAGEKLYKCEECGKAFNQSSNLTTHKIIHTKEKPSKSEECDKAFIWSSTLTEHKRIHTREKTY    841 - 910
KCEECGKAFSQPSHLTTHKRMHTGEKPYKCEECGKAFSQSSTLTTHKIIHTGEKPYKCEECGKAFRKSST    911 - 980
LTEHKIIHTGEKPYKCEECGKAFSQSSTLTRHTRMHTGEKPYKCEECGKAFNRSSKLTTHKIIHTGEKPY    981 - 1050
KCEECGKAFISSSTLNGHKRIHTREKPYKCEECGKAFSQSSTLTRHKRLHTGEKPYKCGECGKAFKESSA   1051 - 1120
LTKHKIIHTGEKPYKCEKCGKAFNQSSILTNHKKIHTITPVIPLLWEAEAGGSRGQEMETILANTVKPLL   1121 - 1190
Y//

Text Mined References (13)

PMID Year Title
25274305 2014 An evolutionary arms race between KRAB zinc-finger genes ZNF91/93 and SVA/L1 retrotransposons.
23665872 2013 Novel activity of KRAB domain that functions to reinforce nuclear localization of KRAB-containing zinc finger proteins by interacting with KAP1.
19240061 2009 Coeliac disease-associated risk variants in TNFAIP3 and REL implicate altered NF-kappaB signalling.
16730941 2006 A systematic analysis of human CHMP protein interactions: additional MIT domain-containing proteins bind to multiple components of the human ESCRT III complex.
16606703 2006 Evolutionary expansion and divergence in the ZNF91 subfamily of primate-specific zinc finger genes.
16344560 2006 Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes.
15057824 2004 The DNA sequence and biology of human chromosome 19.
14702039 2004 Complete sequencing and characterization of 21,243 full-length human cDNAs.
11470777 2001 Characterization of the human Fc gamma RIIB gene promoter: human zinc-finger proteins (ZNF140 and ZNF91) that bind to different regions function as transcription repressors.
8467795 1993 Clustered organization of homologous KRAB zinc-finger genes with enhanced expression in human T lymphoid cells.
7479878 1995 Emergence of the ZNF91 Krüppel-associated box-containing zinc finger gene family in the last common ancestor of anthropoidea.
2505992 The human genome contains hundreds of genes coding for finger proteins of the Krüppel type.
2023909 1991 The evolutionarily conserved Krüppel-associated box domain defines a subfamily of eukaryotic multifingered proteins.