| Tbio | Zinc finger protein 91 |
Transcription factor specifically required to repress SINE-VNTR-Alu (SVA) retrotransposons: recognizes and binds SVA sequences and represses their expression by recruiting a repressive complex containing TRIM28/KAP1 (PubMed:25274305). May also bind the promoter of the FCGR2B gene, leading to repress its expression; however, additional evidences are required to confirm this result in vivo (PubMed:11470777).
The ZNF91 gene encodes a zinc finger protein of the KRAB (Kruppel-associated box) subfamily (Bellefroid et al., 1991, 1993 [PubMed 2023909] [PubMed 8467795]).[supplied by OMIM, May 2010]
The ZNF91 gene encodes a zinc finger protein of the KRAB (Kruppel-associated box) subfamily (Bellefroid et al., 1991, 1993 [PubMed 2023909] [PubMed 8467795]).[supplied by OMIM, May 2010]
Comments
| Disease | Target Count | P-value |
|---|---|---|
| psoriasis | 6694 | 1.7e-24 |
| malignant mesothelioma | 3232 | 7.0e-09 |
| ulcerative colitis | 1819 | 3.6e-08 |
| ependymoma | 4679 | 1.0e-06 |
| non-small cell lung cancer | 2890 | 1.9e-06 |
| glioblastoma | 5792 | 7.0e-06 |
| medulloblastoma, large-cell | 6241 | 8.9e-06 |
| osteosarcoma | 7950 | 1.1e-05 |
| hepatocellular carcinoma | 547 | 1.8e-05 |
| ovarian cancer | 8520 | 2.8e-05 |
| fascioscapulohumeral muscular dystrophy | 100 | 1.8e-04 |
| Astrocytoma, Pilocytic | 3081 | 6.2e-04 |
| primary Sjogren syndrome | 735 | 9.6e-04 |
| adult high grade glioma | 3801 | 1.2e-03 |
| gastric cancer | 459 | 1.3e-03 |
| interstitial cystitis | 2312 | 1.9e-03 |
| invasive ductal carcinoma | 2951 | 2.8e-03 |
| astrocytoma | 1146 | 4.2e-03 |
| ductal carcinoma in situ | 1745 | 7.6e-03 |
| group 4 medulloblastoma | 1855 | 1.1e-02 |
| dermatomyositis | 966 | 2.0e-02 |
| Waldenstrons macroglobulinemia | 765 | 2.2e-02 |
| intraductal papillary-mucinous adenoma (IPMA) | 2955 | 3.4e-02 |
| spina bifida | 1074 | 4.0e-02 |
| Disease | Target Count | Z-score | Confidence |
|---|---|---|---|
| Carcinoma | 11493 | 0.0 | 1.4 |
| Immune system cancer | 140 | 0.0 | 0.5 |
| Kidney cancer | 2613 | 0.0 | 0.6 |
| Liver cancer | 604 | 0.0 | 0.5 |
| Lymphoid leukemia | 160 | 0.0 | 0.5 |
| lung cancer | 4740 | 0.0 | 0.9 |
| Disease | log2 FC | p |
|---|---|---|
| adult high grade glioma | -1.600 | 1.2e-03 |
| astrocytoma | -2.100 | 4.2e-03 |
| Astrocytoma, Pilocytic | -1.100 | 6.2e-04 |
| dermatomyositis | -1.200 | 2.0e-02 |
| ductal carcinoma in situ | 1.100 | 7.6e-03 |
| ependymoma | -1.200 | 1.0e-06 |
| fascioscapulohumeral muscular dystrophy | -1.155 | 1.8e-04 |
| gastric cancer | 1.200 | 1.3e-03 |
| glioblastoma | -1.200 | 7.0e-06 |
| group 4 medulloblastoma | 1.100 | 1.1e-02 |
| hepatocellular carcinoma | 1.500 | 1.8e-05 |
| interstitial cystitis | -1.700 | 1.9e-03 |
| intraductal papillary-mucinous adenoma (... | 1.100 | 3.4e-02 |
| invasive ductal carcinoma | -1.441 | 2.8e-03 |
| malignant mesothelioma | -3.900 | 7.0e-09 |
| medulloblastoma, large-cell | -1.400 | 8.9e-06 |
| non-small cell lung cancer | -1.099 | 1.9e-06 |
| osteosarcoma | 2.580 | 1.1e-05 |
| ovarian cancer | 2.000 | 2.8e-05 |
| primary Sjogren syndrome | 1.100 | 9.6e-04 |
| psoriasis | -1.400 | 1.7e-24 |
| spina bifida | -2.622 | 4.0e-02 |
| ulcerative colitis | -1.600 | 3.6e-08 |
| Waldenstrons macroglobulinemia | 1.038 | 2.2e-02 |
MPGTPGSLEMGLLTFRDVAIEFSPEEWQCLDTAQQNLYRNVMLENYRNLAFLGIALSKPDLITYLEQGKE 1 - 70 PWNMKQHEMVDEPTGICPHFPQDFWPEQSMEDSFQKVLLRKYEKCGHENLQLRKGCKSVDECKVHKEGYN 71 - 140 KLNQCLTTAQSKVFQCGKYLKVFYKFLNSNRHTIRHTGKKCFKCKKCVKSFCIRLHKTQHKCVYITEKSC 141 - 210 KCKECEKTFHWSSTLTNHKEIHTEDKPYKCEECGKAFKQLSTLTTHKIICAKEKIYKCEECGKAFLWSST 211 - 280 LTRHKRIHTGEKPYKCEECGKAFSHSSTLAKHKRIHTGEKPYKCEECGKAFSRSSTLAKHKRIHTGEKPY 281 - 350 KCKECGKAFSNSSTLANHKITHTEEKPYKCKECDKAFKRLSTLTKHKIIHAGEKLYKCEECGKAFNRSSN 351 - 420 LTIHKFIHTGEKPYKCEECGKAFNWSSSLTKHKRFHTREKPFKCKECGKAFIWSSTLTRHKRIHTGEKPY 421 - 490 KCEECGKAFRQSSTLTKHKIIHTGEKPYKFEECGKAFRQSLTLNKHKIIHSREKPYKCKECGKAFKQFST 491 - 560 LTTHKIIHAGKKLYKCEECGKAFNHSSSLSTHKIIHTGEKSYKCEECGKAFLWSSTLRRHKRIHTGEKPY 561 - 630 KCEECGKAFSHSSALAKHKRIHTGEKPYKCKECGKAFSNSSTLANHKITHTEEKPYKCKECDKTFKRLST 631 - 700 LTKHKIIHAGEKLYKCEECGKAFNRSSNLTIHKFIHTGEKPYKCEECGKAFNWSSSLTKHKRIHTREKPF 701 - 770 KCKECGKAFIWSSTLTRHKRIHTGEKPYKCEECGKAFSRSSTLTKHKTIHTGEKPYKCKECGKAFKHSSA 771 - 840 LAKHKIIHAGEKLYKCEECGKAFNQSSNLTTHKIIHTKEKPSKSEECDKAFIWSSTLTEHKRIHTREKTY 841 - 910 KCEECGKAFSQPSHLTTHKRMHTGEKPYKCEECGKAFSQSSTLTTHKIIHTGEKPYKCEECGKAFRKSST 911 - 980 LTEHKIIHTGEKPYKCEECGKAFSQSSTLTRHTRMHTGEKPYKCEECGKAFNRSSKLTTHKIIHTGEKPY 981 - 1050 KCEECGKAFISSSTLNGHKRIHTREKPYKCEECGKAFSQSSTLTRHKRLHTGEKPYKCGECGKAFKESSA 1051 - 1120 LTKHKIIHTGEKPYKCEKCGKAFNQSSILTNHKKIHTITPVIPLLWEAEAGGSRGQEMETILANTVKPLL 1121 - 1190 Y//
