| Tdark | Zinc finger protein 75D |
May be involved in transcriptional regulation.
This gene encodes a protein that likely functions as a transcription factor. The protein, which belongs to the ZNF75 family, includes an N-terminal SCAN domain, a KRAB box, and five C2H2-type zinc finger motifs. Another functional gene belonging to this family is located on chromosome 16, while pseudogenes have been identified on chromosomes 11 and 12. Alternative splicing results in multiple transcripts variants. [provided by RefSeq, Jun 2010]
This gene encodes a protein that likely functions as a transcription factor. The protein, which belongs to the ZNF75 family, includes an N-terminal SCAN domain, a KRAB box, and five C2H2-type zinc finger motifs. Another functional gene belonging to this family is located on chromosome 16, while pseudogenes have been identified on chromosomes 11 and 12. Alternative splicing results in multiple transcripts variants. [provided by RefSeq, Jun 2010]
Comments
| Disease | Target Count | P-value |
|---|---|---|
| osteosarcoma | 7950 | 2.2e-08 |
| ovarian cancer | 8520 | 3.2e-06 |
| lung cancer | 4740 | 1.0e-04 |
| psoriasis | 6694 | 1.1e-04 |
| adrenocortical adenoma | 131 | 3.9e-03 |
| intraductal papillary-mucinous adenoma (IPMA) | 2955 | 4.8e-03 |
| intraductal papillary-mucinous neoplasm (IPMN) | 3291 | 2.7e-02 |
| Breast cancer | 3578 | 2.8e-02 |
| Disease | log2 FC | p |
|---|---|---|
| adrenocortical adenoma | 1.005 | 3.9e-03 |
| Breast cancer | 2.100 | 2.8e-02 |
| intraductal papillary-mucinous adenoma (... | 1.300 | 4.8e-03 |
| intraductal papillary-mucinous neoplasm ... | 1.400 | 2.7e-02 |
| lung cancer | -1.400 | 1.0e-04 |
| osteosarcoma | -2.487 | 2.2e-08 |
| ovarian cancer | 1.300 | 3.2e-06 |
| psoriasis | -1.900 | 1.1e-04 |
MAMRELNADSCSSPQMGAMWETSGSVKENSSQSKKYSTKIENLGPESACRHFWSFRYHEATGPLETISQL 1 - 70 QKLCHQWLRPEIHSKEQILEMLVLEQFLSILPKETQNWVQKHHPQNVKQALVLVEFLQREPDGTKNEVTA 71 - 140 HELGKEAVLLGGTAVAPGFKWKPAEPQPMGVFQKEYWNTYRVLQEQLGWNTHKETQPVYERAVHDQQMLA 141 - 210 LSEQKRIKHWKMASKLILPESLSLLTFEDVAVYFSEEEWQLLNPLEKTLYNDVMQDIYETVISLGLKLKN 211 - 280 DTGNDHPISVSTSEIQTSGCEVSKKTRMKIAQKTMGRENPGDTHSVQKWHRAFPRKKRKKPATCKQELPK 281 - 350 LMDLHGKGPTGEKPFKCQECGKSFRVSSDLIKHHRIHTGEKPYKCQQCDRRFRWSSDLNKHFMTHQGIKP 351 - 420 YRCSWCGKSFSHNTNLHTHQRIHTGEKPFKCDECGKRFIQNSHLIKHQRTHTGEQPYTCSLCKRNFSRRS 421 - 490 SLLRHQKLHRRREACLVSPN 491 - 510 //
