| Tbio | Palmitoyltransferase ZDHHC3 |
Palmitoyltransferase with broad specificity (PubMed:21926431, PubMed:23034182). Palmitoylates GABA receptors on their gamma subunit (GABRG1, GABRG2 and GABRG3), which regulates synaptic clustering and/or cell surface stability (By similarity). Palmitoylates glutamate receptors GRIA1 and GRIA2, which leads to their retention in Golgi. May also palmitoylate DLG4, DNAJC5 and SNAP25 (By similarity).
Comments
| Disease | Target Count | P-value |
|---|---|---|
| osteosarcoma | 7950 | 1.4e-05 |
| atypical teratoid / rhabdoid tumor | 5112 | 3.6e-05 |
| medulloblastoma, large-cell | 6241 | 5.2e-05 |
| intraductal papillary-mucinous carcinoma (IPMC) | 2989 | 2.2e-04 |
| interstitial cystitis | 2312 | 3.5e-04 |
| group 4 medulloblastoma | 1855 | 8.4e-04 |
| intraductal papillary-mucinous adenoma (IPMA) | 2955 | 2.9e-03 |
| Disease | log2 FC | p |
|---|---|---|
| atypical teratoid / rhabdoid tumor | -1.100 | 3.6e-05 |
| group 4 medulloblastoma | -1.100 | 8.4e-04 |
| interstitial cystitis | -1.100 | 3.5e-04 |
| intraductal papillary-mucinous adenoma (... | 1.100 | 2.9e-03 |
| intraductal papillary-mucinous carcinoma... | 1.100 | 2.2e-04 |
| medulloblastoma, large-cell | -1.400 | 5.2e-05 |
| osteosarcoma | -1.611 | 1.4e-05 |
MMLIPTHHFRNIERKPEYLQPEKCVPPPYPGPVGTMWFIRDGCGIACAIVTWFLVLYAEFVVLFVMLIPS 1 - 70 RDYVYSIINGIVFNLLAFLALASHCRAMLTDPGAVPKGNATKEFIESLQLKPGQVVYKCPKCCSIKPDRA 71 - 140 HHCSVCKRCIRKMDHHCPWVNNCVGENNQKYFVLFTMYIALISLHALIMVGFHFLHCFEEDWTKCSSFSP 141 - 210 PTTVILLILLCFEGLLFLIFTSVMFGTQVHSICTDETGIEQLKKEERRWAKKTKWMNMKAVFGHPFSLGW 211 - 280 ASPFATPDQGKADPYQYVV 281 - 299 //
