Property Summary

NCBI Gene PubMed Count 14
PubMed Score 225.68
PubTator Score 18.25

Knowledge Summary

Patent

No data available

Expression

  Differential Expression (11)

Gene RIF (4)

PMID Text
26134560 MCPIP1 and MCPIP4 form a complex but they act independently in regulation of IL-6 mRNA degradation.
26059755 The data indicated that ZC3H12D could suppress both the initial inflammation storm and chronic inflammation by targeting the mRNA of cytokines as well as NF-kappaB and c-fos.
22036805 Zc3h12d is a novel negative feedback regulator of TLR signaling and macrophage activation and thus may play a role in host immunity and inflammatory diseases.
18178554 MCPIP1, 2, 3, and 4, encoded by four genes, Zc3h12a, Zc3h12b, Zc3h12c, and Zc3h12d, respectively, regulates macrophage activation.

AA Sequence

MEHPSKMEFFQKLGYDREDVLRVLGKLGEGALVNDVLQELIRTGSRPGALEHPAAPRLVPRGSCGVPDSA      1 - 70
QRGPGTALEEDFRTLASSLRPIVIDGSNVAMSHGNKETFSCRGIKLAVDWFRDRGHTYIKVFVPSWRKDP     71 - 140
PRADTPIREQHVLAELERQAVLVYTPSRKVHGKRLVCYDDRYIVKVAYEQDGVIVSNDNYRDLQSENPEW    141 - 210
KWFIEQRLLMFSFVNDRFMPPDDPLGRHGPSLSNFLSRKPKPPEPSWQHCPYGKKCTYGIKCKFYHPERP    211 - 280
HHAQLAVADELRAKTGARPGAGAEEQRPPRAPGGSAGARAAPREPFAHSLPPARGSPDLAALRGSFSRLA    281 - 350
FSDDLGPLGPPLPVPACSLTPRLGGPDWVSAGGRVPGPLSLPSPESQFSPGDLPPPPGLQLQPRGEHRPR    351 - 420
DLHGDLLSPRRPPDDPWARPPRSDRFPGRSVWAEPAWGDGATGGLSVYATEDDEGDARARARIALYSVFP    421 - 490
RDQVDRVMAAFPELSDLARLILLVQRCQSAGAPLGKP                                     491 - 527
//

Text Mined References (14)

PMID Year Title
26134560 2015 Monocyte Chemotactic Protein-induced Protein 1 and 4 Form a Complex but Act Independently in Regulation of Interleukin-6 mRNA Degradation.
26059755 2015 ZC3H12D attenuated inflammation responses by reducing mRNA stability of proinflammatory genes.
24415781 2014 Posttranscriptional modulation of cytokine production in T cells for the regulation of excessive inflammation by TFL.
22036805 2012 The putative tumor suppressor Zc3h12d modulates toll-like receptor signaling in macrophages.
21732829 2011 Wnt signaling and Dupuytren's disease.
19531561 2009 Inhibition of G(1) to S phase progression by a novel zinc finger protein P58(TFL) at P-bodies.
18178554 2008 A novel CCCH-zinc finger protein family regulates proinflammatory activation of macrophages.
18029348 2008 Toward a confocal subcellular atlas of the human proteome.
17854321 2007 Deregulation of a possible tumour suppressor gene, ZC3H12D, by translocation of IGK@ in transformed follicular lymphoma with t(2;6)(p12;q25).
17210687 2007 Identification of a novel tumor suppressor gene p34 on human chromosome 6q25.1.
15489334 2004 The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
14702039 2004 Complete sequencing and characterization of 21,243 full-length human cDNAs.
14574404 2003 The DNA sequence and analysis of human chromosome 6.
12477932 2002 Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.