| Tbio | 14-3-3 protein epsilon |
Adapter protein implicated in the regulation of a large spectrum of both general and specialized signaling pathways. Binds to a large number of partners, usually by recognition of a phosphoserine or phosphothreonine motif. Binding generally results in the modulation of the activity of the binding partner (By similarity). Positively regulates phosphorylated protein HSF1 nuclear export to the cytoplasm (PubMed:12917326).
This gene product belongs to the 14-3-3 family of proteins which mediate signal transduction by binding to phosphoserine-containing proteins. This highly conserved protein family is found in both plants and mammals, and this protein is 100% identical to the mouse ortholog. It interacts with CDC25 phosphatases, RAF1 and IRS1 proteins, suggesting its role in diverse biochemical activities related to signal transduction, such as cell division and regulation of insulin sensitivity. It has also been implicated in the pathogenesis of small cell lung cancer. Two transcript variants, one protein-coding and the other non-protein-coding, have been found for this gene. [provided by RefSeq, Aug 2008]
This gene product belongs to the 14-3-3 family of proteins which mediate signal transduction by binding to phosphoserine-containing proteins. This highly conserved protein family is found in both plants and mammals, and this protein is 100% identical to the mouse ortholog. It interacts with CDC25 phosphatases, RAF1 and IRS1 proteins, suggesting its role in diverse biochemical activities related to signal transduction, such as cell division and regulation of insulin sensitivity. It has also been implicated in the pathogenesis of small cell lung cancer. Two transcript variants, one protein-coding and the other non-protein-coding, have been found for this gene. [provided by RefSeq, Aug 2008]
Comments
| Disease | Target Count | Z-score | Confidence |
|---|---|---|---|
| Neoplasm Metastasis | 168 | 0.0 | 0.0 |
| Disease | Target Count | P-value |
|---|---|---|
| ovarian cancer | 8520 | 1.4e-06 |
| osteosarcoma | 7950 | 1.9e-06 |
| Pick disease | 1894 | 1.6e-05 |
| psoriasis | 6694 | 1.2e-04 |
| Multiple myeloma | 1332 | 4.4e-04 |
| dermatomyositis | 966 | 2.4e-03 |
| medulloblastoma, large-cell | 6241 | 3.1e-03 |
| oligodendroglioma | 2850 | 3.6e-03 |
| Rheumatoid arthritis | 1191 | 4.4e-03 |
| Down syndrome | 499 | 7.1e-03 |
| interstitial cystitis | 2312 | 7.3e-03 |
| hereditary spastic paraplegia | 318 | 8.4e-03 |
| ependymoma | 4679 | 2.0e-02 |
| atypical teratoid / rhabdoid tumor | 5112 | 2.4e-02 |
| group 4 medulloblastoma | 1855 | 4.4e-02 |
| Disease | Target Count | Z-score | Confidence |
|---|---|---|---|
| Endometrial stromal nodule | 11 | 5.106 | 2.6 |
| Sarcoma | 62 | 4.244 | 2.1 |
| Left ventricular noncompaction | 26 | 3.814 | 1.9 |
| Leiomyosarcoma | 24 | 3.75 | 1.9 |
| Juvenile astrocytoma | 3 | 3.438 | 1.7 |
| Tricuspid valve stenosis | 6 | 3.104 | 1.6 |
| Disease | log2 FC | p |
|---|---|---|
| atypical teratoid / rhabdoid tumor | 1.200 | 2.4e-02 |
| dermatomyositis | -2.700 | 2.4e-03 |
| Down syndrome | 1.900 | 7.1e-03 |
| ependymoma | 1.400 | 2.0e-02 |
| group 4 medulloblastoma | 1.500 | 4.4e-02 |
| hereditary spastic paraplegia | -1.769 | 8.4e-03 |
| interstitial cystitis | -1.400 | 7.3e-03 |
| medulloblastoma, large-cell | 1.600 | 3.1e-03 |
| Multiple myeloma | 1.234 | 4.4e-04 |
| oligodendroglioma | 1.200 | 3.6e-03 |
| osteosarcoma | 2.401 | 1.9e-06 |
| ovarian cancer | -1.200 | 1.4e-06 |
| Pick disease | -1.700 | 1.6e-05 |
| psoriasis | -2.000 | 1.2e-04 |
| Rheumatoid arthritis | -2.400 | 4.4e-03 |
