Tbio VPS54 Vacuolar protein sorting-associated protein 54

Protein Summary

Description

Acts as component of the GARP complex that is involved in retrograde transport from early and late endosomes to the trans-Golgi network (TGN). The GARP complex is required for the maintenance of the cycling of mannose 6-phosphate receptors between the TGN and endosomes, this cycling is necessary for proper lysosomal sorting of acid hydrolases such as CTSD (PubMed:18367545). Within the GARP complex, required to tether the complex to the TGN. Not involved in endocytic recycling (PubMed:25799061). This gene encodes for a protein that in yeast forms part of a trimeric vacuolar-protein-sorting complex that is required for retrograde transport of proteins from prevacuoles to the late Golgi compartment. As in yeast, mammalian Vps54 proteins contain a coiled-coil region and dileucine motifs. Alternative splicing results in multiple transcript variants encoding different isoforms [provided by RefSeq, Jul 2008]

Uniprot Accession IDs

• Q9P1Q0
• Q5VIR5
• Q86YF7
• Q8N6G3
• Q9NPV0
• Q9NT07
• Q9NUJ0

Gene Name

• VPS54

Ensembl ID

• ENST00000272322
• ENSP00000272322
• ENSG00000143952
• ENST00000354504
• ENSP00000346499
• ENST00000409558
• ENSP00000386980

Symbol

• HCC8
• WR
• HCC8
• SLP-8p
• VPS54L
• hVps54L
• PPP1R164

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
histone modification site profile	0.86
transcription factor binding site profile	0.75
kinase perturbation	0.66
tissue sample	0.65
small molecule perturbation	0.61

Protein Classes

PANTHER Classes

Protein / Transfer/carrier Protein / Vacuolar Protein Sorting-associated Protein 54

Protein / Nucleic Acid Binding / Vacuolar Protein Sorting-associated Protein 54

DTO Classes

Protein / Transporter / Vacuolar Protein Sorting-associated Protein 54

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 22.73   (req: < 5)

Gene RIFs: 9   (req: <= 3)

Antibodies: 132   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 22.73   (req: >= 5)

Gene RIFs: 9   (req: > 3)

Antibodies: 132   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 9

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0