| Tbio | Vesicle-associated membrane protein 3 |
SNARE involved in vesicular transport from the late endosomes to the trans-Golgi network.
Synaptobrevins/VAMPs, syntaxins, and the 25-kD synaptosomal-associated protein are the main components of a protein complex involved in the docking and/or fusion of synaptic vesicles with the presynaptic membrane. This gene is a member of the vesicle-associated membrane protein (VAMP)/synaptobrevin family. Because of its high homology to other known VAMPs, its broad tissue distribution, and its subcellular localization, the protein encoded by this gene was shown to be the human equivalent of the rodent cellubrevin. In platelets the protein resides on a compartment that is not mobilized to the plasma membrane on calcium or thrombin stimulation. [provided by RefSeq, Jul 2008]
Synaptobrevins/VAMPs, syntaxins, and the 25-kD synaptosomal-associated protein are the main components of a protein complex involved in the docking and/or fusion of synaptic vesicles with the presynaptic membrane. This gene is a member of the vesicle-associated membrane protein (VAMP)/synaptobrevin family. Because of its high homology to other known VAMPs, its broad tissue distribution, and its subcellular localization, the protein encoded by this gene was shown to be the human equivalent of the rodent cellubrevin. In platelets the protein resides on a compartment that is not mobilized to the plasma membrane on calcium or thrombin stimulation. [provided by RefSeq, Jul 2008]
Comments
| Disease | Target Count |
|---|---|
| Bipolar Disorder | 666 |
| MAJOR AFFECTIVE DISORDER 2 | 22 |
| Disease | Target Count | P-value |
|---|---|---|
| ependymoma | 4679 | 7.5e-10 |
| ovarian cancer | 8520 | 1.0e-09 |
| malignant mesothelioma | 3232 | 4.3e-06 |
| Astrocytoma, Pilocytic | 3081 | 6.9e-05 |
| group 4 medulloblastoma | 1855 | 2.1e-04 |
| lung adenocarcinoma | 2716 | 2.1e-04 |
| osteosarcoma | 7950 | 4.9e-04 |
| medulloblastoma, large-cell | 6241 | 5.8e-04 |
| Down syndrome | 499 | 7.7e-04 |
| psoriasis | 6694 | 8.0e-04 |
| Multiple myeloma | 1332 | 9.1e-04 |
| lung cancer | 4740 | 3.2e-03 |
| invasive ductal carcinoma | 2951 | 4.7e-03 |
| pediatric high grade glioma | 1064 | 5.2e-03 |
| glioblastoma | 5792 | 6.8e-03 |
| Atopic dermatitis | 952 | 8.0e-03 |
| primary pancreatic ductal adenocarcinoma | 1109 | 9.5e-03 |
| atypical teratoid / rhabdoid tumor | 5112 | 1.5e-02 |
| dermatomyositis | 966 | 1.7e-02 |
| gastric cancer | 459 | 1.8e-02 |
| pancreatic carcinoma | 562 | 2.4e-02 |
| pancreatic cancer | 2398 | 2.4e-02 |
| Gaucher disease type 1 | 180 | 2.4e-02 |
| esophageal adenocarcinoma | 737 | 3.2e-02 |
| Disease | log2 FC | p |
|---|---|---|
| Astrocytoma, Pilocytic | 1.500 | 6.9e-05 |
| Atopic dermatitis | -1.200 | 8.0e-03 |
| atypical teratoid / rhabdoid tumor | 1.100 | 1.5e-02 |
| dermatomyositis | -1.100 | 1.7e-02 |
| Down syndrome | 2.600 | 7.7e-04 |
| ependymoma | 1.800 | 7.5e-10 |
| esophageal adenocarcinoma | -1.400 | 3.2e-02 |
| gastric cancer | -1.300 | 1.8e-02 |
| Gaucher disease type 1 | -1.400 | 2.4e-02 |
| glioblastoma | 1.400 | 6.8e-03 |
| group 4 medulloblastoma | -1.600 | 2.1e-04 |
| invasive ductal carcinoma | -1.100 | 4.7e-03 |
| lung adenocarcinoma | 1.422 | 2.1e-04 |
| lung cancer | -1.300 | 3.2e-03 |
| malignant mesothelioma | -1.100 | 4.3e-06 |
| medulloblastoma, large-cell | -1.600 | 5.8e-04 |
| Multiple myeloma | 1.303 | 9.1e-04 |
| osteosarcoma | 1.848 | 4.9e-04 |
| ovarian cancer | -2.100 | 1.0e-09 |
| pancreatic cancer | -1.300 | 2.4e-02 |
| pancreatic carcinoma | -1.300 | 2.4e-02 |
| pediatric high grade glioma | 1.300 | 5.2e-03 |
| primary pancreatic ductal adenocarcinoma | 1.055 | 9.5e-03 |
| psoriasis | 1.100 | 8.0e-04 |
