Tbio | Uronyl 2-sulfotransferase |
Sulfotransferase that catalyzes the transfer of sulfate to the position 2 of uronyl residues. Has mainly activity toward iduronyl residues in dermatan sulfate, and weaker activity toward glucuronyl residues of chondroitin sulfate. Has no activity toward desulfated N-resulfated heparin.
Uronyl 2-sulfotransferase transfers sulfate to the 2-position of uronyl residues, such as iduronyl residues in dermatan sulfate and glucuronyl residues in chondroitin sulfate (Kobayashi et al., 1999 [PubMed 10187838]).[supplied by OMIM, Mar 2008]
Uronyl 2-sulfotransferase transfers sulfate to the 2-position of uronyl residues, such as iduronyl residues in dermatan sulfate and glucuronyl residues in chondroitin sulfate (Kobayashi et al., 1999 [PubMed 10187838]).[supplied by OMIM, Mar 2008]
Comments
Disease | Target Count | Z-score | Confidence |
---|---|---|---|
Endometriosis | 540 | 0.0 | 0.0 |
Disease | Target Count | P-value |
---|---|---|
lung adenocarcinoma | 2716 | 8.5e-14 |
malignant mesothelioma | 3232 | 2.1e-07 |
psoriasis | 6694 | 2.3e-07 |
lung cancer | 4740 | 1.7e-05 |
posterior fossa group A ependymoma | 468 | 3.1e-05 |
medulloblastoma, large-cell | 6241 | 3.2e-04 |
interstitial cystitis | 2312 | 7.8e-04 |
atypical teratoid / rhabdoid tumor | 5112 | 1.1e-03 |
group 3 medulloblastoma | 4104 | 2.2e-03 |
ductal carcinoma in situ | 1745 | 3.1e-03 |
Atopic dermatitis | 952 | 3.2e-03 |
astrocytic glioma | 2597 | 6.4e-03 |
cutaneous lupus erythematosus | 1057 | 7.5e-03 |
invasive ductal carcinoma | 2951 | 8.4e-03 |
intraductal papillary-mucinous carcinoma (IPMC) | 2989 | 8.4e-03 |
oligodendroglioma | 2850 | 8.8e-03 |
pituitary cancer | 1972 | 1.8e-02 |
primitive neuroectodermal tumor | 3035 | 2.6e-02 |
Disease | Target Count | Z-score | Confidence |
---|---|---|---|
Breast cancer | 3578 | 0.0 | 3.0 |
Crohn's disease | 321 | 0.0 | 1.1 |
Mental Depression | 333 | 0.0 | 3.0 |
Retinal disease | 25 | 0.0 | 1.2 |
Vascular disease | 319 | 0.0 | 1.5 |
Disease | Target Count | Z-score | Confidence |
---|---|---|---|
Female stress incontinence | 7 | 3.93 | 2.0 |
Liver inflammatory pseudotumor | 2 | 3.919 | 2.0 |
Hereditary spherocytosis type 2 | 18 | 3.812 | 1.9 |
Psoriatic arthritis | 86 | 3.516 | 1.8 |
Corneal edema | 14 | 3.312 | 1.7 |
Disease | log2 FC | p |
---|---|---|
psoriasis | -2.100 | 2.3e-07 |
astrocytic glioma | 1.100 | 6.4e-03 |
Atopic dermatitis | -1.200 | 3.2e-03 |
atypical teratoid / rhabdoid tumor | -1.900 | 1.1e-03 |
cutaneous lupus erythematosus | -1.100 | 7.5e-03 |
ductal carcinoma in situ | -1.700 | 3.1e-03 |
group 3 medulloblastoma | -2.200 | 2.2e-03 |
interstitial cystitis | -1.100 | 7.8e-04 |
intraductal papillary-mucinous carcinoma... | -1.800 | 8.4e-03 |
invasive ductal carcinoma | -1.382 | 8.4e-03 |
lung adenocarcinoma | -1.200 | 8.5e-14 |
lung cancer | -2.300 | 1.7e-05 |
malignant mesothelioma | -2.200 | 2.1e-07 |
medulloblastoma, large-cell | -2.800 | 3.2e-04 |
oligodendroglioma | 1.100 | 8.8e-03 |
pituitary cancer | -1.100 | 1.8e-02 |
posterior fossa group A ependymoma | 1.100 | 3.1e-05 |
primitive neuroectodermal tumor | -1.700 | 2.6e-02 |
Species | Source | Disease |
---|---|---|
Inparanoid OMA | ||
Inparanoid OMA EggNOG | ||
Inparanoid OMA EggNOG | ||
Inparanoid OMA EggNOG | ||
Inparanoid OMA EggNOG | ||
OMA EggNOG | ||
Inparanoid OMA EggNOG | ||
OMA EggNOG | ||
OMA EggNOG | ||
Inparanoid OMA EggNOG | ||
Inparanoid OMA EggNOG | ||
Inparanoid OMA EggNOG | ||
OMA EggNOG |
MKKKQQHPGGGADPWPHGAPMGGAPPGLGSWKRRVPLLPFLRFSLRDYGFCMATLLVFCLGSLLYQLSGG 1 - 70 PPRFLLDLRQYLGNSTYLDDHGPPPSKVLPFPSQVVYNRVGKCGSRTVVLLLRILSEKHGFNLVTSDIHN 71 - 140 KTRLTKNEQMELIKNISTAEQPYLFTRHVHFLNFSRFGGDQPVYINIIRDPVNRFLSNYFFRRFGDWRGE 141 - 210 QNHMIRTPSMRQEERYLDINECILENYPECSNPRLFYIIPYFCGQHPRCREPGEWALERAKLNVNENFLL 211 - 280 VGILEELEDVLLLLERFLPHYFKGVLSIYKDPEHRKLGNMTVTVKKTVPSPEAVQILYQRMRYEYEFYHY 281 - 350 VKEQFHLLKRKFGLKSHVSKPPLRPHFFIPTPLETEEPIDDEEQDDEKWLEDIYKR 351 - 406 //