| Tbio | Uronyl 2-sulfotransferase |
Sulfotransferase that catalyzes the transfer of sulfate to the position 2 of uronyl residues. Has mainly activity toward iduronyl residues in dermatan sulfate, and weaker activity toward glucuronyl residues of chondroitin sulfate. Has no activity toward desulfated N-resulfated heparin.
Uronyl 2-sulfotransferase transfers sulfate to the 2-position of uronyl residues, such as iduronyl residues in dermatan sulfate and glucuronyl residues in chondroitin sulfate (Kobayashi et al., 1999 [PubMed 10187838]).[supplied by OMIM, Mar 2008]
Uronyl 2-sulfotransferase transfers sulfate to the 2-position of uronyl residues, such as iduronyl residues in dermatan sulfate and glucuronyl residues in chondroitin sulfate (Kobayashi et al., 1999 [PubMed 10187838]).[supplied by OMIM, Mar 2008]
Comments
| Disease | Target Count | Z-score | Confidence |
|---|---|---|---|
| Endometriosis | 540 | 0.0 | 0.0 |
| Disease | Target Count | P-value |
|---|---|---|
| lung adenocarcinoma | 2716 | 8.5e-14 |
| malignant mesothelioma | 3232 | 2.1e-07 |
| psoriasis | 6694 | 2.3e-07 |
| lung cancer | 4740 | 1.7e-05 |
| posterior fossa group A ependymoma | 468 | 3.1e-05 |
| medulloblastoma, large-cell | 6241 | 3.2e-04 |
| interstitial cystitis | 2312 | 7.8e-04 |
| atypical teratoid / rhabdoid tumor | 5112 | 1.1e-03 |
| group 3 medulloblastoma | 4104 | 2.2e-03 |
| ductal carcinoma in situ | 1745 | 3.1e-03 |
| Atopic dermatitis | 952 | 3.2e-03 |
| astrocytic glioma | 2597 | 6.4e-03 |
| cutaneous lupus erythematosus | 1057 | 7.5e-03 |
| invasive ductal carcinoma | 2951 | 8.4e-03 |
| intraductal papillary-mucinous carcinoma (IPMC) | 2989 | 8.4e-03 |
| oligodendroglioma | 2850 | 8.8e-03 |
| pituitary cancer | 1972 | 1.8e-02 |
| primitive neuroectodermal tumor | 3035 | 2.6e-02 |
| Disease | Target Count | Z-score | Confidence |
|---|---|---|---|
| Breast cancer | 3578 | 0.0 | 3.0 |
| Crohn's disease | 321 | 0.0 | 1.1 |
| Mental Depression | 333 | 0.0 | 3.0 |
| Retinal disease | 25 | 0.0 | 1.2 |
| Vascular disease | 319 | 0.0 | 1.5 |
| Disease | Target Count | Z-score | Confidence |
|---|---|---|---|
| Female stress incontinence | 7 | 3.93 | 2.0 |
| Liver inflammatory pseudotumor | 2 | 3.919 | 2.0 |
| Hereditary spherocytosis type 2 | 18 | 3.812 | 1.9 |
| Psoriatic arthritis | 86 | 3.516 | 1.8 |
| Corneal edema | 14 | 3.312 | 1.7 |
| Disease | log2 FC | p |
|---|---|---|
| psoriasis | -2.100 | 2.3e-07 |
| astrocytic glioma | 1.100 | 6.4e-03 |
| Atopic dermatitis | -1.200 | 3.2e-03 |
| atypical teratoid / rhabdoid tumor | -1.900 | 1.1e-03 |
| cutaneous lupus erythematosus | -1.100 | 7.5e-03 |
| ductal carcinoma in situ | -1.700 | 3.1e-03 |
| group 3 medulloblastoma | -2.200 | 2.2e-03 |
| interstitial cystitis | -1.100 | 7.8e-04 |
| intraductal papillary-mucinous carcinoma... | -1.800 | 8.4e-03 |
| invasive ductal carcinoma | -1.382 | 8.4e-03 |
| lung adenocarcinoma | -1.200 | 8.5e-14 |
| lung cancer | -2.300 | 1.7e-05 |
| malignant mesothelioma | -2.200 | 2.1e-07 |
| medulloblastoma, large-cell | -2.800 | 3.2e-04 |
| oligodendroglioma | 1.100 | 8.8e-03 |
| pituitary cancer | -1.100 | 1.8e-02 |
| posterior fossa group A ependymoma | 1.100 | 3.1e-05 |
| primitive neuroectodermal tumor | -1.700 | 2.6e-02 |
| Species | Source | Disease |
|---|---|---|
| Inparanoid OMA | ||
| Inparanoid OMA EggNOG | ||
| Inparanoid OMA EggNOG | ||
| Inparanoid OMA EggNOG | ||
| Inparanoid OMA EggNOG | ||
| OMA EggNOG | ||
| Inparanoid OMA EggNOG | ||
| OMA EggNOG | ||
| OMA EggNOG | ||
| Inparanoid OMA EggNOG | ||
| Inparanoid OMA EggNOG | ||
| Inparanoid OMA EggNOG | ||
| OMA EggNOG |
MKKKQQHPGGGADPWPHGAPMGGAPPGLGSWKRRVPLLPFLRFSLRDYGFCMATLLVFCLGSLLYQLSGG 1 - 70 PPRFLLDLRQYLGNSTYLDDHGPPPSKVLPFPSQVVYNRVGKCGSRTVVLLLRILSEKHGFNLVTSDIHN 71 - 140 KTRLTKNEQMELIKNISTAEQPYLFTRHVHFLNFSRFGGDQPVYINIIRDPVNRFLSNYFFRRFGDWRGE 141 - 210 QNHMIRTPSMRQEERYLDINECILENYPECSNPRLFYIIPYFCGQHPRCREPGEWALERAKLNVNENFLL 211 - 280 VGILEELEDVLLLLERFLPHYFKGVLSIYKDPEHRKLGNMTVTVKKTVPSPEAVQILYQRMRYEYEFYHY 281 - 350 VKEQFHLLKRKFGLKSHVSKPPLRPHFFIPTPLETEEPIDDEEQDDEKWLEDIYKR 351 - 406 //
