| Tdark | UBX domain-containing protein 4 |
Involved in endoplasmic reticulum-associated protein degradation (ERAD). Acts as a platform to recruit both UBQLN1 and VCP to the ER during ERAD (PubMed:19822669).
UBXD2 is an integral membrane protein of the endoplasmic reticulum (ER) that binds valosin-containing protein (VCP; MIM 601023) and promotes ER-associated protein degradation (ERAD) (Liang et al., 2006 [PubMed 16968747]).[supplied by OMIM, Mar 2008]
UBXD2 is an integral membrane protein of the endoplasmic reticulum (ER) that binds valosin-containing protein (VCP; MIM 601023) and promotes ER-associated protein degradation (ERAD) (Liang et al., 2006 [PubMed 16968747]).[supplied by OMIM, Mar 2008]
Comments
| Disease | Target Count | P-value |
|---|---|---|
| juvenile dermatomyositis | 1187 | 6.8e-07 |
| atypical teratoid / rhabdoid tumor | 5112 | 1.2e-06 |
| Pick disease | 1894 | 2.6e-06 |
| medulloblastoma, large-cell | 6241 | 6.1e-06 |
| ovarian cancer | 8520 | 6.3e-05 |
| osteosarcoma | 7950 | 7.6e-05 |
| lung adenocarcinoma | 2716 | 1.1e-04 |
| primitive neuroectodermal tumor | 3035 | 2.7e-04 |
| acute quadriplegic myopathy | 1158 | 3.0e-04 |
| dermatomyositis | 966 | 5.8e-04 |
| hereditary spastic paraplegia | 318 | 1.0e-03 |
| glioblastoma | 5792 | 1.1e-03 |
| Down syndrome | 499 | 1.3e-03 |
| Rheumatoid arthritis | 1191 | 2.5e-03 |
| group 4 medulloblastoma | 1855 | 4.2e-03 |
| progressive supranuclear palsy | 676 | 5.4e-03 |
| Multiple myeloma | 1332 | 8.5e-03 |
| Gaucher disease type 1 | 180 | 1.1e-02 |
| ependymoma | 4679 | 1.3e-02 |
| Becker muscular dystrophy | 191 | 2.6e-02 |
| autosomal dominant Emery-Dreifuss muscular dystrophy | 510 | 2.9e-02 |
| Alzheimer's disease | 658 | 4.8e-02 |
| acute myeloid leukemia | 783 | 4.9e-02 |
| Disease | Target Count | Z-score | Confidence |
|---|---|---|---|
| Corneal disease | 31 | 0.0 | 1.7 |
| Paget's disease of bone | 36 | 0.0 | 1.4 |
| Disease | Target Count | Z-score | Confidence |
|---|---|---|---|
| Kufor-Rakeb syndrome | 4 | 4.152 | 2.1 |
| Disease | Target Count |
|---|---|
| Keratoconus | 113 |
| Disease | log2 FC | p |
|---|---|---|
| acute myeloid leukemia | 1.900 | 4.9e-02 |
| acute quadriplegic myopathy | 1.062 | 3.0e-04 |
| Alzheimer's disease | -1.100 | 4.8e-02 |
| atypical teratoid / rhabdoid tumor | 1.600 | 1.2e-06 |
| autosomal dominant Emery-Dreifuss muscul... | -1.203 | 2.9e-02 |
| Becker muscular dystrophy | -1.229 | 2.6e-02 |
| dermatomyositis | -1.200 | 5.8e-04 |
| Down syndrome | 1.600 | 1.3e-03 |
| ependymoma | 1.100 | 1.3e-02 |
| Gaucher disease type 1 | -1.300 | 1.1e-02 |
| glioblastoma | 1.400 | 1.1e-03 |
| group 4 medulloblastoma | 1.400 | 4.2e-03 |
| hereditary spastic paraplegia | -1.391 | 1.0e-03 |
| juvenile dermatomyositis | 1.313 | 6.8e-07 |
| lung adenocarcinoma | 1.020 | 1.1e-04 |
| medulloblastoma, large-cell | 2.000 | 6.1e-06 |
| Multiple myeloma | 1.152 | 8.5e-03 |
| osteosarcoma | 1.244 | 7.6e-05 |
| ovarian cancer | -1.600 | 6.3e-05 |
| Pick disease | -1.300 | 2.6e-06 |
| primitive neuroectodermal tumor | 1.100 | 2.7e-04 |
| progressive supranuclear palsy | -1.600 | 5.4e-03 |
| Rheumatoid arthritis | 2.200 | 2.5e-03 |
MLWFQGAIPAAIATAKRSGAVFVVFVAGDDEQSTQMAASWEDDKVTEASSNSFVAIKIDTKSEACLQFSQ 1 - 70 IYPVVCVPSSFFIGDSGIPLEVIAGSVSADELVTRIHKVRQMHLLKSETSVANGSQSESSVSTPSASFEP 71 - 140 NNTCENSQSRNAELCEIPPTSDTKSDTATGGESAGHATSSQEPSGCSDQRPAEDLNIRVERLTKKLEERR 141 - 210 EEKRKEEEQREIKKEIERRKTGKEMLDYKRKQEEELTKRMLEERNREKAEDRAARERIKQQIALDRAERA 211 - 280 ARFAKTKEEVEAAKAAALLAKQAEMEVKRESYARERSTVARIQFRLPDGSSFTNQFPSDAPLEEARQFAA 281 - 350 QTVGNTYGNFSLATMFPRREFTKEDYKKKLLDLELAPSASVVLLPAGRPTASIVHSSSGDIWTLLGTVLY 351 - 420 PFLAIWRLISNFLFSNPPPTQTSVRVTSSEPPNPASSSKSEKREPVRKRVLEKRGDDFKKEGKIYRLRTQ 421 - 490 DDGEDENNTWNGNSTQQM 491 - 508 //
