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Tbio
TRAF3
TNF receptor-associated factor 3

Protein Summary
Description
Regulates pathways leading to the activation of NF-kappa-B and MAP kinases, and plays a central role in the regulation of B-cell survival. Part of signaling pathways leading to the production of cytokines and interferon. Required for normal antibody isotype switching from IgM to IgG. Plays a role T-cell dependent immune responses. Plays a role in the regulation of antiviral responses. Is an essential constituent of several E3 ubiquitin-protein ligase complexes. May have E3 ubiquitin-protein ligase activity and promote 'Lys-63'-linked ubiquitination of target proteins. Inhibits activation of NF-kappa-B in response to LTBR stimulation. Inhibits TRAF2-mediated activation of NF-kappa-B. Down-regulates proteolytic processing of NFKB2, and thereby inhibits non-canonical activation of NF-kappa-B. Promotes ubiquitination and proteasomal degradation of MAP3K14. The protein encoded by this gene is a member of the TNF receptor associated factor (TRAF) protein family. TRAF proteins associate with, ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000392745
  • ENSP00000376500
  • ENSG00000131323
  • ENST00000539721
  • ENSP00000445998
  • ENST00000560371
  • ENSP00000454207

Symbol
  • CAP1
  • CRAF1
  • CAP1
  • LAP1
  • CAP-1
  • CRAF1
  • IIAE5
  • CD40bp
  • RNF118
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
protein domain
0.99
disease perturbation
0.98
hub protein
0.85
molecular function
0.84
virus perturbation
0.79


Protein Classes
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 489.85   (req: < 5)
Gene RIFs: 136   (req: <= 3)
Antibodies: 495   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 489.85   (req: >= 5)
Gene RIFs: 136   (req: > 3)
Antibodies: 495   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 21
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0