| Tbio | p53-regulated apoptosis-inducing protein 1 |
May play an important role in mediating p53/TP53-dependent apoptosis.
This gene is specifically expressed in the thymus, and encodes a protein that is localized to the mitochondrion. The expression of this gene is inducible by p53, and it is thought to play an important role in mediating p53-dependent apoptosis. Alternatively spliced transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, Oct 2011]
This gene is specifically expressed in the thymus, and encodes a protein that is localized to the mitochondrion. The expression of this gene is inducible by p53, and it is thought to play an important role in mediating p53-dependent apoptosis. Alternatively spliced transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, Oct 2011]
Comments
| Disease | Target Count | P-value |
|---|---|---|
| Breast cancer | 3578 | 7.1e-32 |
| psoriasis | 6694 | 6.1e-04 |
| medulloblastoma, large-cell | 6241 | 8.9e-04 |
| group 3 medulloblastoma | 4104 | 5.5e-03 |
| esophageal adenocarcinoma | 737 | 1.8e-02 |
| non primary Sjogren syndrome sicca | 891 | 2.0e-02 |
| Disease | log2 FC | p |
|---|---|---|
| Breast cancer | -1.100 | 7.1e-32 |
| esophageal adenocarcinoma | -1.100 | 1.8e-02 |
| group 3 medulloblastoma | 1.100 | 5.5e-03 |
| medulloblastoma, large-cell | 1.100 | 8.9e-04 |
| non primary Sjogren syndrome sicca | -1.200 | 2.0e-02 |
| psoriasis | -2.000 | 6.1e-04 |
