Tbio TM9SF2 Transmembrane 9 superfamily member 2

Protein Summary

Description

In the intracellular compartments, may function as a channel or small molecule transporter. This gene encodes a member of the transmembrane 9 superfamily. The encoded 76 kDa protein localizes to early endosomes in human cells. The encoded protein possesses a conserved and highly hydrophobic C-terminal domain which contains nine transmembrane domains. The protein may play a role in small molecule transport or act as an ion channel. A pseudogene associated with this gene is located on the X chromosome. [provided by RefSeq, Oct 2012]

Uniprot Accession IDs

• Q99805
• A8K399
• Q2TAY5

Gene Name

• TM9SF2

Ensembl ID

• ENST00000376387
• ENSP00000365567
• ENSG00000125304
• ENST00000642475
• ENSP00000493515

Symbol

• P76

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
virus perturbation	1
transcription factor binding site profile	0.82
kinase perturbation	0.76
disease perturbation	0.74
transcription factor perturbation	0.74

Protein Classes

PANTHER Classes

Protein / Transporter / Transmembrane 9 Superfamily Member 2

DTO Classes

Protein / Transporter / Transmembrane 9 Superfamily Member 2

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 6.72   (req: < 5)

Gene RIFs: 7   (req: <= 3)

Antibodies: 69   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 6.72   (req: >= 5)

Gene RIFs: 7   (req: > 3)

Antibodies: 69   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Term: 1

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0