TGFBR3
Transforming growth factor beta receptor type 3
Protein Summary
Binds to TGF-beta. Could be involved in capturing and retaining TGF-beta for presentation to the signaling receptors. This locus encodes the transforming growth factor (TGF)-beta type III receptor. The encoded receptor is a membrane proteoglycan that often functions as a co-receptor with other TGF-beta receptor superfamily members. Ectodomain shedding produces soluble TGFBR3, which may inhibit TGFB signaling. Decreased expression of this receptor has been observed in various cancers. Alternatively spliced transcript variants encoding different isoforms have been identified for this gene.[provided by RefSeq, Sep 2010]
- ENST00000212355
- ENSP00000212355
- ENSG00000069702
- ENST00000370399
- ENSP00000359426
- ENST00000465892
- ENSP00000432638
- ENST00000525962
- ENSP00000436127
- BGCAN
- betaglycan
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
PubMedID | 1 | ||
molecular function | 0.99 | ||
biological process | 0.98 | ||
disease | 0.87 | ||
gene perturbation | 0.87 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 150.15 (req: < 5)
Gene RIFs: 112 (req: <= 3)
Antibodies: 407 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 150.15 (req: >= 5)
Gene RIFs: 112 (req: > 3)
Antibodies: 407 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 47
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligand: 0
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0