| Tbio | Nesprin-3 |
As a component of the LINC (LInker of Nucleoskeleton and Cytoskeleton) complex involved in the connection between the nuclear lamina and the cytoskeleton. The nucleocytoplasmic interactions established by the LINC complex play an important role in the transmission of mechanical forces across the nuclear envelope and in nuclear movement and positioning. Probable anchoring protein which tethers the nucleus to the cytoskeleton by binding PLEC which can associate with the intermediate filament system. Plays a role in the regulation of aortic epithelial cell morphology, and is required for flow-induced centrosome polarization and directional migration in aortic endothelial cells.
Comments
| Disease | Target Count | P-value |
|---|---|---|
| non-small cell lung cancer | 2890 | 1.3e-15 |
| lung adenocarcinoma | 2716 | 5.3e-14 |
| ovarian cancer | 8520 | 4.9e-08 |
| Astrocytoma, Pilocytic | 3081 | 1.6e-07 |
| ependymoma | 4679 | 3.8e-07 |
| Duchenne muscular dystrophy | 601 | 4.3e-07 |
| limb girdle muscular dystrophy 2A | 213 | 9.7e-06 |
| psoriasis | 6694 | 9.8e-06 |
| tuberculosis | 2010 | 3.6e-05 |
| invasive ductal carcinoma | 2951 | 1.3e-04 |
| malignant mesothelioma | 3232 | 1.4e-04 |
| ductal carcinoma in situ | 1745 | 3.6e-04 |
| breast carcinoma | 1638 | 7.4e-04 |
| fibroadenoma | 559 | 4.5e-03 |
| Down syndrome | 499 | 4.6e-03 |
| autosomal dominant Emery-Dreifuss muscular dystrophy | 510 | 4.6e-03 |
| lung cancer | 4740 | 5.3e-03 |
| medulloblastoma, large-cell | 6241 | 6.6e-03 |
| progressive supranuclear palsy | 676 | 1.3e-02 |
| intraductal papillary-mucinous carcinoma (IPMC) | 2989 | 1.8e-02 |
| osteosarcoma | 7950 | 2.0e-02 |
| adrenocortical carcinoma | 1428 | 2.6e-02 |
| pediatric high grade glioma | 1064 | 2.7e-02 |
| spina bifida | 1074 | 3.0e-02 |
| Disease | Target Count | Z-score | Confidence |
|---|---|---|---|
| Endocervical adenocarcinoma | 3 | 3.859 | 1.9 |
| Cervical squamous cell carcinoma | 10 | 3.13 | 1.6 |
| Bladder urothelial carcinoma | 4 | 3.097 | 1.5 |
| Disease | log2 FC | p |
|---|---|---|
| adrenocortical carcinoma | -1.141 | 2.6e-02 |
| Astrocytoma, Pilocytic | 2.300 | 1.6e-07 |
| autosomal dominant Emery-Dreifuss muscul... | 1.347 | 4.6e-03 |
| breast carcinoma | -1.900 | 7.4e-04 |
| Down syndrome | 1.100 | 4.6e-03 |
| Duchenne muscular dystrophy | 1.504 | 4.3e-07 |
| ductal carcinoma in situ | -2.000 | 3.6e-04 |
| ependymoma | 1.700 | 3.8e-07 |
| fibroadenoma | -2.600 | 4.5e-03 |
| intraductal papillary-mucinous carcinoma... | -1.200 | 1.8e-02 |
| invasive ductal carcinoma | -3.300 | 1.3e-04 |
| limb girdle muscular dystrophy 2A | 1.155 | 9.7e-06 |
| lung adenocarcinoma | -1.500 | 5.3e-14 |
| lung cancer | -2.400 | 5.3e-03 |
| malignant mesothelioma | 1.300 | 1.4e-04 |
| medulloblastoma, large-cell | -1.100 | 6.6e-03 |
| non-small cell lung cancer | -1.817 | 1.3e-15 |
| osteosarcoma | -1.289 | 2.0e-02 |
| ovarian cancer | -2.300 | 4.9e-08 |
| pediatric high grade glioma | 1.200 | 2.7e-02 |
| progressive supranuclear palsy | -1.100 | 1.3e-02 |
| psoriasis | -1.200 | 9.8e-06 |
| spina bifida | 1.267 | 3.0e-02 |
| tuberculosis | 1.100 | 3.6e-05 |
MTQQPQDDFDRSVEDAQAWMKAVQDQLQVNDNTQGPRAALEARLWETEKICQLEPEGRVRVDLVLRMAEA 1 - 70 LLACCPGDQKPGILARLKDIKAQWEETVTYMTHCHSRIEWVWLHWSEYLLARDEFYRWFQKMMVTLEPHI 71 - 140 ELQLGLKEKQWQLSHAQVLLHNVDNQAVLLDRLLEEAASLFNRIGDPSVDEDAQKRMKAEYDAVKAKAQK 141 - 210 RVDLLEQVAREHEEYQAGVDEFQLWLKAVVEKVNGCLGRNCKLPITQRLSTLQDIAKDFPRGEESLETLE 211 - 280 EQSAGVIRNTSPLGAEKITGELEEMRKVLEKLRALWEEEEERLRGLLRSRGAWEQQIKQLEAELSEFRMV 281 - 350 LQRLAQEGLQPAAKAGTEDELVAHWRRYSATRAALASEEPRVDRLQAQLKELIVFPHNLKPLSDSVIATI 351 - 420 QEYQSLKVKSARLRNAAAVELWQHFQRPLQDLQLWKALAQRLLEVTASLPDLPSLHTFLPQIEAALMESS 421 - 490 RLKELLTMLQLKKDLLIGIFGQERATALLEQVAGSMRDRDLLHNSLLQRKSKLQSLLAQHKDFGAAFEPL 491 - 560 QRKLLDLQVRVQAEKGLQRDLPGKQAQLSRLQGLQEEGLDLGAQMEAARPLVQENPNHQHKMDQLSSDFQ 561 - 630 ALQRSLEDLVDRCRQSVQEHCTFSHQLLELRQWIVVTTQKLEAHRGEAGPGDAESQEAEFERLVAEFPEK 631 - 700 EAQLSLVEAQGWLVMEKSSPEGAAVVQEELRELAESWRALRLLEESLLSLIRNWHLQRMEVDSGKKMVFT 701 - 770 NNIPKSGFLINPMDPIPRHRRRANLLQEEEGSHEDFSQLLRNFGQWLQVENSKLVRIIAMRTSTAEDLRT 771 - 840 RKSKLQELEARVPEGQHLFENLLRLGPARGTSDELEDLRYQWMLYKSKLKDSGHLLTQSSPGEPTGFQKT 841 - 910 RRWRGLGSLFRRACCVALPLQLLLLLFLLLLFLLPIREEDRSCTLANNFARSFTLMLRYNGPPPT 911 - 975 //
