| Tbio | Nesprin-3 |
Component of SUN-protein-containing multivariate complexes also called LINC complexes which link the nucleoskeleton and cytoskeleton by providing versatile outer nuclear membrane attachment sites for cytoskeletal filaments. Involved in the maintenance of nuclear organization and structural integrity. Probable anchoring protein which tethers the nucleus to the cytoskeleton by binding PLEC which can associate with the intermediate filament system. Plays a role in the regulation of aortic epithelial cell morphology, and is required for flow-induced centrosome polarization and directional migration in aortic endothelial cells.
Comments
| Disease | Target Count | P-value |
|---|---|---|
| non-small cell lung cancer | 2798 | 1.3e-15 |
| lung adenocarcinoma | 2714 | 2.3e-10 |
| posterior fossa group A ependymoma | 1511 | 3.3e-09 |
| ovarian cancer | 8491 | 4.9e-08 |
| pilocytic astrocytoma | 3086 | 1.2e-07 |
| Duchenne muscular dystrophy | 602 | 4.3e-07 |
| tuberculosis and treatment for 3 months | 327 | 7.8e-06 |
| limb girdle muscular dystrophy 2A | 156 | 9.7e-06 |
| psoriasis | 6685 | 9.8e-06 |
| lung cancer | 4473 | 5.1e-05 |
| invasive ductal carcinoma | 2950 | 1.3e-04 |
| malignant mesothelioma | 3163 | 1.4e-04 |
| ductal carcinoma in situ | 1745 | 3.6e-04 |
| breast carcinoma | 1614 | 7.4e-04 |
| fibroadenoma | 557 | 4.5e-03 |
| Down syndrome | 548 | 4.6e-03 |
| autosomal dominant Emery-Dreifuss muscular dystrophy | 499 | 4.6e-03 |
| medulloblastoma, large-cell | 6234 | 6.6e-03 |
| progressive supranuclear palsy | 674 | 1.3e-02 |
| intraductal papillary-mucinous carcinoma (IPMC) | 2988 | 1.8e-02 |
| osteosarcoma | 7933 | 2.0e-02 |
| adrenocortical carcinoma | 1427 | 2.6e-02 |
| pediatric high grade glioma | 2712 | 2.7e-02 |
| spina bifida | 1064 | 3.0e-02 |
| Disease | Target Count | Z-score | Confidence |
|---|---|---|---|
| Endocervical adenocarcinoma | 4 | 4.066 | 2.0 |
| Cervical squamous cell carcinoma | 5 | 3.341 | 1.7 |
| Disease | log2 FC | p |
|---|---|---|
| malignant mesothelioma | 1.300 | 1.4e-04 |
| psoriasis | -1.200 | 9.8e-06 |
| osteosarcoma | -1.289 | 2.0e-02 |
| posterior fossa group A ependymoma | 1.900 | 3.3e-09 |
| medulloblastoma, large-cell | -1.100 | 6.6e-03 |
| Duchenne muscular dystrophy | 1.504 | 4.3e-07 |
| autosomal dominant Emery-Dreifuss muscul... | 1.347 | 4.6e-03 |
| limb girdle muscular dystrophy 2A | 1.155 | 9.7e-06 |
| adrenocortical carcinoma | -1.141 | 2.6e-02 |
| tuberculosis and treatment for 3 months | 1.200 | 7.8e-06 |
| non-small cell lung cancer | -1.817 | 1.3e-15 |
| intraductal papillary-mucinous carcinoma... | -1.200 | 1.8e-02 |
| lung cancer | -3.200 | 5.1e-05 |
| breast carcinoma | -1.900 | 7.4e-04 |
| fibroadenoma | -2.600 | 4.5e-03 |
| pediatric high grade glioma | 1.200 | 2.7e-02 |
| pilocytic astrocytoma | 2.300 | 1.2e-07 |
| lung adenocarcinoma | -1.799 | 2.3e-10 |
| spina bifida | 1.267 | 3.0e-02 |
| progressive supranuclear palsy | -1.100 | 1.3e-02 |
| ductal carcinoma in situ | -2.000 | 3.6e-04 |
| invasive ductal carcinoma | -3.300 | 1.3e-04 |
| ovarian cancer | -2.300 | 4.9e-08 |
| Down syndrome | 1.100 | 4.6e-03 |
| PMID | Text | |
|---|---|---|
| 21937718 | nesprin-3 regulates vascular endothelial cell shape, perinuclear cytoskeletal architecture, and important aspects of flow-mediated mechanotransduction. | |
| 18827015 | association with human nesprin-3 appeared to be stronger for torsinADeltaE than for torsinA. TorsinA also associated with the KASH domains of nesprin-1 and -2 |
MTQQPQDDFDRSVEDAQAWMKAVQDQLQVNDNTQGPRAALEARLWETEKICQLEPEGRVRVDLVLRMAEA 1 - 70 LLACCPGDQKPGILARLKDIKAQWEETVTYMTHCHSRIEWVWLHWSEYLLARDEFYRWFQKMMVTLEPHI 71 - 140 ELQLGLKEKQWQLSHAQVLLHNVDNQAVLLDRLLEEAASLFNRIGDPSVDEDAQKRMKAEYDAVKAKAQK 141 - 210 RVDLLEQVAREHEEYQAGVDEFQLWLKAVVEKVNGCLGRNCKLPITQRLSTLQDIAKDFPRGEESLETLE 211 - 280 EQSAGVIRNTSPLGAEKITGELEEMRKVLEKLRALWEEEEERLRGLLRSRGAWEQQIKQLEAELSEFRMV 281 - 350 LQRLAQEGLQPAAKAGTEDELVAHWRRYSATRAALASEEPRVDRLQAQLKELIVFPHNLKPLSDSVIATI 351 - 420 QEYQSLKVKSARLRNAAAVELWQHFQRPLQDLQLWKALAQRLLEVTASLPDLPSLHTFLPQIEAALMESS 421 - 490 RLKELLTMLQLKKDLLIGIFGQERATALLEQVAGSMRDRDLLHNSLLQRKSKLQSLLAQHKDFGAAFEPL 491 - 560 QRKLLDLQVRVQAEKGLQRDLPGKQAQLSRLQGLQEEGLDLGAQMEAARPLVQENPNHQHKMDQLSSDFQ 561 - 630 ALQRSLEDLVDRCRQSVQEHCTFSHQLLELRQWIVVTTQKLEAHRGEAGPGDAESQEAEFERLVAEFPEK 631 - 700 EAQLSLVEAQGWLVMEKSSPEGAAVVQEELRELAESWRALRLLEESLLSLIRNWHLQRMEVDSGKKMVFT 701 - 770 NNIPKSGFLINPMDPIPRHRRRANLLQEEEGSHEDFSQLLRNFGQWLQVENSKLVRIIAMRTSTAEDLRT 771 - 840 RKSKLQELEARVPEGQHLFENLLRLGPARGTSDELEDLRYQWMLYKSKLKDSGHLLTQSSPGEPTGFQKT 841 - 910 RRWRGLGSLFRRACCVALPLQLLLLLFLLLLFLLPIREEDRSCTLANNFARSFTLMLRYNGPPPT 911 - 975 //
| PMID | Year | Title | |
|---|---|---|---|
| 24049095 | 2013 | Genome-wide association study of sex hormones, gonadotropins and sex hormone-binding protein in Chinese men. | |
| 23478653 | 2014 | A genome-wide association study of survival in small-cell lung cancer patients treated with irinotecan plus cisplatin chemotherapy. | |
| 22518138 | 2012 | Cytoskeletal interactions at the nuclear envelope mediated by nesprins. | |
| 21937718 | 2011 | Nesprin-3 regulates endothelial cell morphology, perinuclear cytoskeletal architecture, and flow-induced polarization. | |
| 20068231 | 2010 | Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis. | |
| 19946888 | 2010 | Defining the membrane proteome of NK cells. | |
| 18827015 | 2008 | TorsinA binds the KASH domain of nesprins and participates in linkage between nuclear envelope and cytoskeleton. | |
| 18396275 | 2008 | Structural requirements for the assembly of LINC complexes and their function in cellular mechanical stiffness. | |
| 16330710 | 2005 | Nesprin-3, a novel outer nuclear membrane protein, associates with the cytoskeletal linker protein plectin. | |
| 15489334 | 2004 | The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). | |
| 14702039 | 2004 | Complete sequencing and characterization of 21,243 full-length human cDNAs. | |
| 12508121 | 2003 | The DNA sequence and analysis of human chromosome 14. | |
| 12477932 | 2002 | Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. | |
| 11181995 | 2001 | The sequence of the human genome. | |
| 8889548 | 1996 | Normalization and subtraction: two approaches to facilitate gene discovery. |
