Tchem STAMBP STAM-binding protein

Protein Summary

Description

Zinc metalloprotease that specifically cleaves 'Lys-63'-linked polyubiquitin chains. Does not cleave 'Lys-48'-linked polyubiquitin chains (By similarity). Plays a role in signal transduction for cell growth and MYC induction mediated by IL-2 and GM-CSF. Potentiates BMP (bone morphogenetic protein) signaling by antagonizing the inhibitory action of SMAD6 and SMAD7. Has a key role in regulation of cell surface receptor-mediated endocytosis and ubiquitin-dependent sorting of receptors to lysosomes. Endosomal localization of STAMBP is required for efficient EGFR degradation but not for its internalization (By similarity). Involved in the negative regulation of PI3K-AKT-mTOR and RAS-MAP signaling pathways. Cytokine-mediated signal transduction in the JAK-STAT cascade requires the involvement of adaptor molecules. One such signal-transducing adaptor molecule contains an SH3 domain that is required for induction of MYC and cell growth. The protein encoded by this gene binds to the SH3 domain of the signal-transducing adaptor molecule, and plays a critical role in cytokine-mediated signaling for MYC induction and cell cycle progression. Multiple alternatively spliced transcript variants encoding the same protein isoform have been found for this gene. [provided by RefSeq, Jul 2008]

Uniprot Accession IDs

• O95630
• B5M0B6
• D6W5H7
• Q3MJE7

Gene Name

• STAMBP

Ensembl ID

• ENST00000339566
• ENSP00000344742
• ENSG00000124356
• ENST00000394070
• ENSP00000377633
• ENST00000394073
• ENSP00000377636
• ENST00000409707
• ENSP00000386548

Symbol

• AMSH
• AMSH
• MICCAP

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
kinase perturbation	0.91
disease perturbation	0.9
cell type or tissue	0.84
virus perturbation	0.79
histone modification site profile	0.71

Protein Classes

PANTHER Classes

Protein / Signaling Molecule / Cytokine / Stam-binding Protein

Protein / ... / Metalloprotease / Stam-binding Protein

DTO Classes

Protein / Enzyme / Protease / Metalloprotease / Stam-binding Protein

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 108.03   (req: < 5)

Gene RIFs: 31   (req: <= 3)

Antibodies: 277   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 108.03   (req: >= 5)

Gene RIFs: 31   (req: > 3)

Antibodies: 277   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 12

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 6

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0