| Tclin | Smoothened homolog |
The protein encoded by this gene is a G protein-coupled receptor that interacts with the patched protein, a receptor for hedgehog proteins. The encoded protein tranduces signals to other proteins after activation by a hedgehog protein/patched protein complex. [provided by RefSeq, Jul 2010]
Comments
Property Summary
| Ligand Count | 236 |
| NCBI Gene PubMed Count | 111 |
| PubMed Score | 14.45 |
| PubTator Score | 331.28 |
| Disease | Target Count | Z-score | Confidence |
|---|---|---|---|
| Ameloblastoma | 24 | 0.0 | 0.0 |
| Brain Neoplasms | 33 | 0.0 | 0.0 |
| Carcinoma, Basal Cell | 28 | 0.0 | 0.0 |
| Gastrointestinal Stromal Tumors | 48 | 0.0 | 0.0 |
| Infertility, Female | 28 | 0.0 | 0.0 |
| Jaw Abnormalities | 5 | 0.0 | 0.0 |
| Leukemia, Promyelocytic, Acute | 36 | 0.0 | 0.0 |
| Maxillary Neoplasms | 1 | 0.0 | 0.0 |
| Meningioma | 41 | 0.0 | 0.6 |
| Neuroectodermal Tumors, Primitive | 8 | 0.0 | 0.0 |
| Skin Neoplasms | 69 | 0.0 | 0.0 |
| Winter Shortland Temple syndrome | 1 | 0.0 | 0.0 |
| Disease | Target Count |
|---|---|
| Basal cell carcinoma of skin | 2 |
| Disease | Target Count | P-value |
|---|---|---|
| atypical teratoid / rhabdoid tumor | 5112 | 4.3e-10 |
| glioblastoma | 5792 | 2.4e-06 |
| medulloblastoma | 720 | 3.5e-05 |
| osteosarcoma | 7950 | 7.7e-05 |
| medulloblastoma, large-cell | 6241 | 6.0e-03 |
| cutaneous lupus erythematosus | 1057 | 6.9e-03 |
| ependymoma | 4679 | 8.8e-03 |
| lung cancer | 4740 | 9.7e-03 |
| Disease | Target Count | Z-score | Confidence |
|---|---|---|---|
| Nevoid basal cell carcinoma syndrome | 16 | 3.141 | 1.6 |
| Disease | Target Count |
|---|---|
| BCC1 | 3 |
| Curry-Jones syndrome | 1 |
| Disease | log2 FC | p |
|---|---|---|
| atypical teratoid / rhabdoid tumor | 1.900 | 4.3e-10 |
| cutaneous lupus erythematosus | -1.200 | 6.9e-03 |
| ependymoma | 1.100 | 8.8e-03 |
| glioblastoma | 1.300 | 2.4e-06 |
| lung cancer | 1.200 | 9.7e-03 |
| medulloblastoma | 1.300 | 3.5e-05 |
| medulloblastoma, large-cell | 1.100 | 6.0e-03 |
| osteosarcoma | 1.529 | 7.7e-05 |
CHEMBL3696782
pIC50 7.00
CHEMBL1813102
pIC50 7.00
CHEMBL1822294
pIC50 7.00
CHEMBL3696812
pIC50 7.01
CHEMBL1082967
pIC50 7.02
CHEMBL377200
pIC50 7.02
CHEMBL3696783
pIC50 7.02
CHEMBL521558
pIC50 7.02
CHEMBL1813095
pIC50 7.02
CHEMBL3692779
pIC50 7.03
CHEMBL1808284
pIC50 7.03
CHEMBL1082790
pIC50 7.04
CHEMBL1822446
pIC50 7.04
CHEMBL3692762
pIC50 7.04
CHEMBL3696766
pIC50 7.04
CHEMBL3818034
pIC50 7.04
CHEMBL2059866
pEC50 7.05
CHEMBL3262641
pIC50 7.06
CHEMBL1807229
pIC50 7.06
CHEMBL1807223
pIC50 7.06
MAAARPARGPELPLLGLLLLLLLGDPGRGAASSGNATGPGPRSAGGSARRSAAVTGPPPPLSHCGRAAPC 1 - 70 EPLRYNVCLGSVLPYGATSTLLAGDSDSQEEAHGKLVLWSGLRNAPRCWAVIQPLLCAVYMPKCENDRVE 71 - 140 LPSRTLCQATRGPCAIVERERGWPDFLRCTPDRFPEGCTNEVQNIKFNSSGQCEVPLVRTDNPKSWYEDV 141 - 210 EGCGIQCQNPLFTEAEHQDMHSYIAAFGAVTGLCTLFTLATFVADWRNSNRYPAVILFYVNACFFVGSIG 211 - 280 WLAQFMDGARREIVCRADGTMRLGEPTSNETLSCVIIFVIVYYALMAGVVWFVVLTYAWHTSFKALGTTY 281 - 350 QPLSGKTSYFHLLTWSLPFVLTVAILAVAQVDGDSVSGICFVGYKNYRYRAGFVLAPIGLVLIVGGYFLI 351 - 420 RGVMTLFSIKSNHPGLLSEKAASKINETMLRLGIFGFLAFGFVLITFSCHFYDFFNQAEWERSFRDYVLC 421 - 490 QANVTIGLPTKQPIPDCEIKNRPSLLVEKINLFAMFGTGIAMSTWVWTKATLLIWRRTWCRLTGQSDDEP 491 - 560 KRIKKSKMIAKAFSKRHELLQNPGQELSFSMHTVSHDGPVAGLAFDLNEPSADVSSAWAQHVTKMVARRG 561 - 630 AILPQDISVTPVATPVPPEEQANLWLVEAEISPELQKRLGRKKKRRKRKKEVCPLAPPPELHPPAPAPST 631 - 700 IPRLPQLPRQKCLVAAGAWGAGDSCRQGAWTLVSNPFCPEPSPPQDPFLPSAPAPVAWAHGRRQGLGPIH 701 - 770 SRTNLMDTELMDADSDF 771 - 787 //
