| Tchem | Long-chain fatty acid transport protein 1 |
Comments
| Disease | Target Count | P-value |
|---|---|---|
| inflammatory breast cancer | 404 | 2.9e-04 |
| medulloblastoma, large-cell | 6234 | 4.0e-03 |
| invasive ductal carcinoma | 2950 | 4.1e-03 |
| Disease | Target Count | Z-score | Confidence |
|---|---|---|---|
| Mental depression | 58 | 0.0 | 1.0 |
| Disease | log2 FC | p |
|---|---|---|
| medulloblastoma, large-cell | -1.200 | 4.0e-03 |
| inflammatory breast cancer | -1.400 | 2.9e-04 |
| invasive ductal carcinoma | -1.100 | 4.1e-03 |
CHEMBL2058345
pIC50 6.05
CHEMBL2377618
pIC50 6.11
CHEMBL2058344
pIC50 6.17
CHEMBL2058346
pIC50 6.22
CHEMBL2057220
pIC50 6.24
CHEMBL2058078
pIC50 6.27
CHEMBL2377623
pIC50 6.28
CHEMBL2377762
pIC50 6.31
CHEMBL2377765
pIC50 6.31
CHEMBL2377612
pIC50 6.33
CHEMBL2377767
pIC50 6.37
CHEMBL2377619
pIC50 6.37
CHEMBL2058091
pIC50 6.40
CHEMBL2058339
pIC50 6.40
CHEMBL2058358
pIC50 6.44
CHEMBL2058076
pIC50 6.48
CHEMBL2377614
pIC50 6.48
CHEMBL2377760
pIC50 6.55
CHEMBL2058349
pIC50 6.59
CHEMBL2377761
pIC50 6.60
| PMID | Text | |
|---|---|---|
| 25961023 | Messenger RNAs for three proteins AATK, SLC27A1, and CDKAL1 are preferentially secreted out in exosomes from HIV-1 Nef-expressing cells, and their targeting miRNAs (miR-32 and miR-93*) are retained in these cells | |
| 24120574 | Several proteins that are expressed in the epidermis have been proposed to facilitate the uptake of long-chain fatty acids (LCFA) in mammalian cells, CD36, fatty acid binding protein, and FATP. [review] | |
| 20965718 | Observational study of gene-disease association. (HuGE Navigator) | |
| 20628086 | Observational study of gene-disease association, gene-environment interaction, and pharmacogenomic / toxicogenomic. (HuGE Navigator) | |
| 20416077 | Observational study of gene-disease association and gene-gene interaction. (HuGE Navigator) | |
| 20356843 | FATP1 inhibits 11-cis retinol formation via interaction with the visual cycle retinoid isomerase RPE65 and lecithin:retinol acyltransferase | |
| 19913121 | Observational study of gene-disease association. (HuGE Navigator) | |
| 19361580 | These data reveals the localization and points to a regulatory function of FATP1 in myotube mitochondria. | |
| 18660489 | Observational study of gene-disease association. (HuGE Navigator) | |
| 15978856 | Observational study of gene-disease association. (HuGE Navigator) | |
| 15897321 | FATP1 stimulated transport and consumption of palmitate and oleate, which they channeled away from complete oxidation and toward TAG synthesis. | |
| 12818409 | Observational study of gene-disease association. (HuGE Navigator) | |
| 12818409 | FATP1 might play a role in post-prandial lipid metabolism and development of cardiovascular disease. | |
| 12235169 | exogenously supplied fatty acids are preferentially channeled by an FATP1-linked mechanism into the TG biosynthetic pathway; such internalized lipids downregulate de novo sphingomyelin and cholesterol metabolism in growing 293 cells |
MRAPGAGAASVVSLALLWLLGLPWTWSAAAALGVYVGSGGWRFLRIVCKTARRDLFGLSVLIRVRLELRR 1 - 70 HQRAGHTIPRIFQAVVQRQPERLALVDAGTGECWTFAQLDAYSNAVANLFRQLGFAPGDVVAIFLEGRPE 71 - 140 FVGLWLGLAKAGMEAALLNVNLRREPLAFCLGTSGAKALIFGGEMVAAVAEVSGHLGKSLIKFCSGDLGP 141 - 210 EGILPDTHLLDPLLKEASTAPLAQIPSKGMDDRLFYIYTSGTTGLPKAAIVVHSRYYRMAAFGHHAYRMQ 211 - 280 AADVLYDCLPLYHSAGNIIGVGQCLIYGLTVVLRKKFSASRFWDDCIKYNCTVVQYIGEICRYLLKQPVR 281 - 350 EAERRHRVRLAVGNGLRPAIWEEFTERFGVRQIGEFYGATECNCSIANMDGKVGSCGFNSRILPHVYPIR 351 - 420 LVKVNEDTMELLRDAQGLCIPCQAGEPGLLVGQINQQDPLRRFDGYVSESATSKKIAHSVFSKGDSAYLS 421 - 490 GDVLVMDELGYMYFRDRSGDTFRWRGENVSTTEVEGVLSRLLGQTDVAVYGVAVPGVEGKAGMAAVADPH 491 - 560 SLLDPNAIYQELQKVLAPYARPIFLRLLPQVDTTGTFKIQKTRLQREGFDPRQTSDRLFFLDLKQGHYLP 561 - 630 LNEAVYTRICSGAFAL 631 - 646 //
| PMID | Year | Title | |
|---|---|---|---|
| 25163924 | 2014 | Insulin sensitivity is independent of lipid binding protein trafficking at the plasma membrane in human skeletal muscle: effect of a 3-day, high-fat diet. | |
| 24937540 | 2014 | Association between expression of FABPpm in skeletal muscle and insulin sensitivity in intramyocellular lipid-accumulated nonobese men. | |
| 24120574 | 2014 | Fatty acid transporters in skin development, function and disease. | |
| 24113382 | 2013 | Overexpression of human fatty acid transport protein 2/very long chain acyl-CoA synthetase 1 (FATP2/Acsvl1) reveals distinct patterns of trafficking of exogenous fatty acids. | |
| 23528296 | 2013 | Arylpiperazines as fatty acid transport protein 1 (FATP1) inhibitors with improved potency and pharmacokinetic properties. | |
| 23024797 | 2012 | Overexpressed FATP1, ACSVL4/FATP4 and ACSL1 increase the cellular fatty acid uptake of 3T3-L1 adipocytes but are localized on intracellular membranes. | |
| 20965718 | 2011 | Genetic variability of the fatty acid synthase pathway is not associated with prostate cancer risk in the European Prospective Investigation on Cancer (EPIC). | |
| 20628086 | 2010 | Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study. | |
| 20416077 | 2010 | Identification of type 2 diabetes-associated combination of SNPs using support vector machine. | |
| 20360315 | 2010 | Genome-wide pharmacogenetics of antidepressant response in the GENDEP project. | |
| 20356843 | 2010 | FATP1 inhibits 11-cis retinol formation via interaction with the visual cycle retinoid isomerase RPE65 and lecithin:retinol acyltransferase. | |
| 19946888 | 2010 | Defining the membrane proteome of NK cells. | |
| 19913121 | 2009 | Gene-centric association signals for lipids and apolipoproteins identified via the HumanCVD BeadChip. | |
| 19523918 | 2009 | Regulation of cardiolipin biosynthesis by fatty acid transport protein-1 IN HEK 293 cells. | |
| 19361580 | 2009 | FATP1 localizes to mitochondria and enhances pyruvate dehydrogenase activity in skeletal myotubes. | |
| 18660489 | 2008 | Multiple genetic variants along candidate pathways influence plasma high-density lipoprotein cholesterol concentrations. | |
| 15978856 | Lack of association between certain candidate gene polymorphisms and the metabolic syndrome. | ||
| 15897321 | 2005 | Impact on fatty acid metabolism and differential localization of FATP1 and FAT/CD36 proteins delivered in cultured human muscle cells. | |
| 15489334 | 2004 | The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). | |
| 15057824 | 2004 | The DNA sequence and biology of human chromosome 19. | |
| 14702039 | 2004 | Complete sequencing and characterization of 21,243 full-length human cDNAs. | |
| 12818409 | 2003 | A common polymorphism in the fatty acid transport protein-1 gene associated with elevated post-prandial lipaemia and alterations in LDL particle size distribution. | |
| 12477932 | 2002 | Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. | |
| 12235169 | 2002 | FATP1 channels exogenous FA into 1,2,3-triacyl-sn-glycerol and down-regulates sphingomyelin and cholesterol metabolism in growing 293 cells. | |
| 10873384 | 2000 | The human fatty acid transport protein-1 (SLC27A1; FATP-1) cDNA and gene: organization, chromosomal localization, and expression. | |
| 9671728 | 1998 | A family of fatty acid transporters conserved from mycobacterium to man. | |
| 7954810 | 1994 | Expression cloning and characterization of a novel adipocyte long chain fatty acid transport protein. |
