| Tdark | Selenide, water dikinase 2 |
Synthesizes selenophosphate from selenide and ATP.
This gene encodes an enzyme that catalyzes the production of monoselenophosphate (MSP) from selenide and ATP. MSP is the selenium donor required for synthesis of selenocysteine (Sec), which is co-translationally incorporated into selenoproteins at in-frame UGA codons that normally signal translation termination. The 3' UTRs of selenoprotein mRNAs contain a conserved stem-loop structure, the Sec insertion sequence (SECIS) element, which is necessary for the recognition of UGA as a Sec codon rather than as a stop signal. This protein is itself a selenoprotein containing a Sec residue at its active site, suggesting the existence of an autoregulatory mechanism. It is preferentially expressed in tissues implicated in the synthesis of selenoproteins and in sites of blood cell development. A pseudogene for this locus has been identified on chromosome 5. [provided by RefSeq, May 2017]
This gene encodes an enzyme that catalyzes the production of monoselenophosphate (MSP) from selenide and ATP. MSP is the selenium donor required for synthesis of selenocysteine (Sec), which is co-translationally incorporated into selenoproteins at in-frame UGA codons that normally signal translation termination. The 3' UTRs of selenoprotein mRNAs contain a conserved stem-loop structure, the Sec insertion sequence (SECIS) element, which is necessary for the recognition of UGA as a Sec codon rather than as a stop signal. This protein is itself a selenoprotein containing a Sec residue at its active site, suggesting the existence of an autoregulatory mechanism. It is preferentially expressed in tissues implicated in the synthesis of selenoproteins and in sites of blood cell development. A pseudogene for this locus has been identified on chromosome 5. [provided by RefSeq, May 2017]
Comments
| Disease | Target Count | P-value |
|---|---|---|
| ulcerative colitis | 1819 | 7.3e-08 |
| osteosarcoma | 7950 | 7.3e-06 |
| invasive ductal carcinoma | 2951 | 1.0e-03 |
| lung cancer | 4740 | 1.1e-03 |
| intraductal papillary-mucinous neoplasm (IPMN) | 3291 | 2.4e-03 |
| ovarian cancer | 8520 | 2.7e-03 |
| Waldenstrons macroglobulinemia | 765 | 3.4e-03 |
| non-inflammatory breast cancer | 66 | 9.3e-03 |
| esophageal adenocarcinoma | 737 | 1.8e-02 |
| pancreatic ductal adenocarcinoma liver metastasis | 1962 | 2.6e-02 |
| astrocytic glioma | 2597 | 4.2e-02 |
| Disease | log2 FC | p |
|---|---|---|
| astrocytic glioma | -1.200 | 4.2e-02 |
| esophageal adenocarcinoma | 1.400 | 1.8e-02 |
| intraductal papillary-mucinous neoplasm ... | 1.400 | 2.4e-03 |
| invasive ductal carcinoma | 1.500 | 1.0e-03 |
| lung cancer | 1.100 | 1.1e-03 |
| non-inflammatory breast cancer | 1.200 | 9.3e-03 |
| osteosarcoma | -1.458 | 7.3e-06 |
| ovarian cancer | 1.400 | 2.7e-03 |
| pancreatic ductal adenocarcinoma liver m... | -1.168 | 2.6e-02 |
| ulcerative colitis | -1.300 | 7.3e-08 |
| Waldenstrons macroglobulinemia | 1.165 | 3.4e-03 |
MAEASATGACGEAMAAAEGSSGPAGLTLGRSFSNYRPFEPQALGLSPSWRLTGFSGMKGUGCKVPQEALL 1 - 70 KLLAGLTRPDVRPPLGRGLVGGQEEASQEAGLPAGAGPSPTFPALGIGMDSCVIPLRHGGLSLVQTTDFF 71 - 140 YPLVEDPYMMGRIACANVLSDLYAMGITECDNMLMLLSVSQSMSEEEREKVTPLMVKGFRDAAEEGGTAV 141 - 210 TGGQTVVNPWIIIGGVATVVCQPNEFIMPDSAVVGDVLVLTKPLGTQVAVNAHQWLDNPERWNKVKMVVS 211 - 280 REEVELAYQEAMFNMATLNRTAAGLMHTFNAHAATDITGFGILGHSQNLAKQQRNEVSFVIHNLPIIAKM 281 - 350 AAVSKASGRFGLLQGTSAETSGGLLICLPREQAARFCSEIKSSKYGEGHQAWIVGIVEKGNRTARIIDKP 351 - 420 RVIEVLPRGATAAVLAPDSSNASSEPSS 421 - 448 //
