| Tchem | E-selectin |
The protein encoded by this gene is found in cytokine-stimulated endothelial cells and is thought to be responsible for the accumulation of blood leukocytes at sites of inflammation by mediating the adhesion of cells to the vascular lining. It exhibits structural features such as the presence of lectin- and EGF-like domains followed by short consensus repeat (SCR) domains that contain 6 conserved cysteine residues. These proteins are part of the selectin family of cell adhesion molecules. Adhesion molecules participate in the interaction between leukocytes and the endothelium and appear to be involved in the pathogenesis of atherosclerosis. [provided by RefSeq, Jul 2008]
Comments
Property Summary
| Ligand Count | 106 |
| NCBI Gene PubMed Count | 415 |
| PubMed Score | 2672.11 |
| PubTator Score | 2239.76 |
| Disease | Target Count | Z-score | Confidence |
|---|---|---|---|
| Atrial Fibrillation | 124 | 0.0 | 0.0 |
| Brain Ischemia | 110 | 0.0 | 0.0 |
| Cardiovascular Diseases | 59 | 0.0 | 0.0 |
| Dermatitis, Allergic Contact | 67 | 0.0 | 0.0 |
| Dermatitis, Atopic | 37 | 0.0 | 0.0 |
| Essential Hypertension | 94 | 0.0 | 0.0 |
| Hypercholesterolemia | 44 | 0.0 | 0.0 |
| Multiple Sclerosis | 540 | 0.0 | 0.0 |
| Myocardial Ischemia | 169 | 0.0 | 0.0 |
| Reperfusion Injury | 86 | 0.0 | 0.0 |
| Urticaria | 67 | 0.0 | 0.0 |
| Disease | Target Count |
|---|---|
| IGA Glomerulonephritis | 50 |
| Disease | Target Count | P-value |
|---|---|---|
| periodontitis | 293 | 7.4e-19 |
| psoriasis | 6694 | 1.2e-15 |
| non-small cell lung cancer | 2890 | 1.4e-15 |
| ulcerative colitis | 1819 | 1.8e-04 |
| lung cancer | 4740 | 4.6e-04 |
| non diabetic and post-ischemic heart failure | 200 | 9.7e-04 |
| lung adenocarcinoma | 2716 | 1.7e-03 |
| interstitial cystitis | 2312 | 2.7e-03 |
| Atopic dermatitis | 952 | 6.2e-03 |
| ductal carcinoma in situ | 1745 | 7.1e-03 |
| pancreatic ductal adenocarcinoma liver metastasis | 1962 | 8.4e-03 |
| type II diabetes mellitus and post-ischemic heart failure | 88 | 1.2e-02 |
| cutaneous lupus erythematosus | 1057 | 2.6e-02 |
| head and neck cancer | 271 | 4.9e-02 |
| Disease | log2 FC | p |
|---|---|---|
| psoriasis | 1.500 | 1.2e-15 |
| Atopic dermatitis | 1.900 | 6.2e-03 |
| cutaneous lupus erythematosus | 1.700 | 2.6e-02 |
| ductal carcinoma in situ | 1.300 | 7.1e-03 |
| head and neck cancer | 1.900 | 4.9e-02 |
| interstitial cystitis | 3.200 | 2.7e-03 |
| lung adenocarcinoma | -1.200 | 1.7e-03 |
| lung cancer | -2.700 | 4.6e-04 |
| non diabetic and post-ischemic heart fai... | -1.700 | 9.7e-04 |
| non-small cell lung cancer | -3.605 | 1.4e-15 |
| pancreatic ductal adenocarcinoma liver m... | -1.116 | 8.4e-03 |
| periodontitis | 1.200 | 7.4e-19 |
| type II diabetes mellitus and post-ische... | -1.800 | 1.2e-02 |
| ulcerative colitis | 3.000 | 1.8e-04 |
| Species | Source | Disease |
|---|---|---|
| OMA EggNOG | ||
| Inparanoid OMA EggNOG | ||
| Inparanoid OMA EggNOG | ||
| Inparanoid OMA EggNOG | ||
| Inparanoid OMA EggNOG | ||
| Inparanoid OMA EggNOG | ||
| Inparanoid OMA EggNOG | ||
| Inparanoid OMA EggNOG | ||
| Inparanoid OMA EggNOG |
CHEMBL220255
pIC50 6.00
CHEMBL325286
pIC50 6.03
CHEMBL117452
pIC50 6.06
CHEMBL117367
pIC50 6.06
CHEMBL115534
pIC50 6.06
CHEMBL118358
pIC50 6.08
CHEMBL325893
pIC50 6.10
CHEMBL221163
pIC50 6.10
CHEMBL119348
pIC50 6.11
CHEMBL6381
pIC50 6.16
CHEMBL116958
pIC50 6.17
CHEMBL115462
pIC50 6.17
CHEMBL263080
pIC50 6.18
CHEMBL119522
pIC50 6.19
CHEMBL323832
pIC50 6.20
CHEMBL428508
pIC50 6.21
CHEMBL119711
pIC50 6.22
CHEMBL267938
pIC50 6.22
CHEMBL119861
pIC50 6.28
CHEMBL6371
pIC50 6.30
MIASQFLSALTLVLLIKESGAWSYNTSTEAMTYDEASAYCQQRYTHLVAIQNKEEIEYLNSILSYSPSYY 1 - 70 WIGIRKVNNVWVWVGTQKPLTEEAKNWAPGEPNNRQKDEDCVEIYIKREKDVGMWNDERCSKKKLALCYT 71 - 140 AACTNTSCSGHGECVETINNYTCKCDPGFSGLKCEQIVNCTALESPEHGSLVCSHPLGNFSYNSSCSISC 141 - 210 DRGYLPSSMETMQCMSSGEWSAPIPACNVVECDAVTNPANGFVECFQNPGSFPWNTTCTFDCEEGFELMG 211 - 280 AQSLQCTSSGNWDNEKPTCKAVTCRAVRQPQNGSVRCSHSPAGEFTFKSSCNFTCEEGFMLQGPAQVECT 281 - 350 TQGQWTQQIPVCEAFQCTALSNPERGYMNCLPSASGSFRYGSSCEFSCEQGFVLKGSKRLQCGPTGEWDN 351 - 420 EKPTCEAVRCDAVHQPPKGLVRCAHSPIGEFTYKSSCAFSCEEGFELHGSTQLECTSQGQWTEEVPSCQV 421 - 490 VKCSSLAVPGKINMSCSGEPVFGTVCKFACPEGWTLNGSAARTCGATGHWSGLLPTCEAPTESNIPLVAG 491 - 560 LSAAGLSLLTLAPFLLWLRKCLRKAKKFVPASSCQSLESDGSYQKPSYIL 561 - 610 //
