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Tbio Protein transport protein Sec16B

Required for secretory cargo traffic from the endoplasmic reticulum to the Golgi apparatus and for normal transitional endoplasmic reticulum (tER) organization.

SEC16B is a mammalian homolog of S. cerevisiae Sec16 that is required for organization of transitional endoplasmic reticulum (ER) sites and protein export (Bhattacharyya and Glick, 2007 [PubMed 17192411]).[supplied by OMIM, Jun 2009]

 Comments

Property Summary

NCBI Gene PubMed Count 33
PubMed Score 11.02
PubTator Score 11.44

Knowledge Summary

Patent

No data available

TINX Plot

  Disease (5)

Disease Target Count Z-score Confidence
Body Weight 14 0.0 0.0
Disease Target Count P-value
osteosarcoma 7950 3.7e-05
Disease Target Count Z-score Confidence
Carcinoma 11493 0.0 0.8
Disease Target Count Z-score Confidence
Acquired metabolic disease 336 0.0 3.0
Type 2 diabetes mellitus 272 0.0 0.9
Disease Target Count Z-score Confidence
Obesity 678 4.437 2.2

Expression

  Differential Expression (1)

Disease log2 FC p
osteosarcoma 1.250 3.7e-05

Synonym

Accession Q96JE7 A3EYF1 Q5HYF6 Q8N7D6 Q96GX6
Symbols RGPR
LZTR2
SEC16S
PGPR-p117
RGPR-p117

Gene

SEC16B

  Ortholog (9)

Species Source Disease
Inparanoid OMA EggNOG
Inparanoid OMA
Inparanoid OMA EggNOG
Inparanoid OMA EggNOG
Inparanoid OMA
Inparanoid OMA EggNOG
Inparanoid OMA EggNOG
Inparanoid OMA EggNOG
Inparanoid OMA EggNOG

 UniProt Keyword (11)

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 GO Component (4)

 GO Process (7)

 Compartment GO Term (31)

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 IMPC Phenotype (3)

 MGI Phenotype (2)

 GWAS Trait (22)

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 HCA RNA Cell Line (48)

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Pathway (8)

Protein-protein Interaction (3)

POTEF   SEC13   SEC16A  

Gene RIF (14)

AA Sequence 

MELWAPQRLPQTRGKATAPSKDPDRGFRRDGHHRPVPHSWHNGERFHQWQDNRGSPQPQQEPRADHQQQP      1 - 70
HYASRPGDWHQPVSGVDYYEGGYRNQLYSRPGYENSYQSYQSPTMREEYAYGSYYYHGHPQWLQEERVPR     71 - 140
QRSPYIWHEDYREQKYLDEHHYENQHSPFGTNSETHFQSNSRNPCKDSPASNSGQEWPGELFPGSLLAEA    141 - 210
QKNKPSLASESNLLQQRESGLSSSSYELSQYIRDAPERDDPPASAAWSPVQADVSSAGPKAPMKFYIPHV    211 - 280
PVSFGPGGQLVHVGPSSPTDGQAALVELHSMEVILNDSEEQEEMRSFSGPLIREDVHKVDIMTFCQQKAA    281 - 350
QSCKSETLGSRDSALLWQLLVLLCRQNGSMVGSDIAELLMQDCKKLEKYKRQPPVANLINLTDEDWPVLS    351 - 420
SGTPNLLTGEIPPSVETPAQIVEKFTRLLYYGRKKEALEWAMKNHLWGHALFLSSKMDPQTYSWVMSGFT    421 - 490
STLALNDPLQTLFQLMSGRIPQAATCCGEKQWGDWRPHLAVILSNQAGDPELYQRAIVAIGDTLAGKGLV    491 - 560
EAAHFCYLMAHVPFGHYTVKTDHLVLLGSSHSQEFLKFATTEAIQRTEIFEYCQMLGRPKSFIPSFQVYK    561 - 630
LLYASRLADYGLVSQALHYCEAIGAAVLSQGESSHPVLLVELIKLAEKLKLSDPLVLERRSGDRDLEPDW    631 - 700
LAQLRRQLEQKVAGDIGDPHPTRSDISGAGGTTTENTFYQDFSGCQGYSEAPGYRSALWLTPEQTCLLQP    701 - 770
SPQQPFPLQPGSYPAGGGAGQTGTPRPFYSVPETHLPGTGSSVAVTEATGGTVWEEMLQTHLGPGENTVS    771 - 840
QETSQPPDGQEVISKPQTPLAARPRSISESSASSAKEDEKESSDEADKNSPRNTAQRGKLGDGKEHTKSS    841 - 910
GFGWFSWFRSKPTKNASPAGDEDSSDSPDSEETPRASSPHQAGLGLSLTPSPESPPLPDVSAFSRGRGGG    911 - 980
EGRGSASSGGAAAGAGVGGLSGPESVSFELCSNPGVLLPPPALKGAVPLYNPSQVPQLPTATSLNRPNRL    981 - 1050
AQRRYPTQPC                                                               1051 - 1060
//

Text Mined References (37)

PMID Year Title