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Tbio Protein transport protein Sec16B

Required for secretory cargo traffic from the endoplasmic reticulum to the Golgi apparatus and for normal transitional endoplasmic reticulum (tER) organization.

SEC16B is a mammalian homolog of S. cerevisiae Sec16 that is required for organization of transitional endoplasmic reticulum (ER) sites and protein export (Bhattacharyya and Glick, 2007 [PubMed 17192411]).[supplied by OMIM, Jun 2009]

 Comments

Property Summary

NCBI Gene PubMed Count 33
PubMed Score 11.02
PubTator Score 11.44

Knowledge Summary

Patent

No data available

TINX Plot

  Disease (5)

Disease Target Count Z-score Confidence
Body Weight 14 0.0 0.0
Disease Target Count P-value
osteosarcoma 7950 3.7e-05
Disease Target Count Z-score Confidence
Carcinoma 11493 0.0 0.8
Disease Target Count Z-score Confidence
Acquired metabolic disease 336 0.0 3.0
Type 2 diabetes mellitus 272 0.0 0.9
Disease Target Count Z-score Confidence
Obesity 678 4.437 2.2

Expression

  Differential Expression (1)

Disease log2 FC p
osteosarcoma 1.250 3.7e-05

Synonym

Accession Q96JE7 A3EYF1 Q5HYF6 Q8N7D6 Q96GX6
Symbols RGPR
LZTR2
SEC16S
PGPR-p117
RGPR-p117

Gene

SEC16B

  Ortholog (1)

Species Source Disease
Macaque OMA Inparanoid

 UniProt Keyword (11)

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 GO Component (4)

 GO Process (7)

 Compartment GO Term (31)

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 IMPC Phenotype (3)

 MGI Phenotype (2)

 GWAS Trait (22)

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 HCA RNA Cell Line (48)

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Pathway (8)

Protein-protein Interaction (3)

POTEF   SEC13   SEC16A  

Gene RIF (14)

AA Sequence 

MELWAPQRLPQTRGKATAPSKDPDRGFRRDGHHRPVPHSWHNGERFHQWQDNRGSPQPQQEPRADHQQQP      1 - 70
HYASRPGDWHQPVSGVDYYEGGYRNQLYSRPGYENSYQSYQSPTMREEYAYGSYYYHGHPQWLQEERVPR     71 - 140
QRSPYIWHEDYREQKYLDEHHYENQHSPFGTNSETHFQSNSRNPCKDSPASNSGQEWPGELFPGSLLAEA    141 - 210
QKNKPSLASESNLLQQRESGLSSSSYELSQYIRDAPERDDPPASAAWSPVQADVSSAGPKAPMKFYIPHV    211 - 280
PVSFGPGGQLVHVGPSSPTDGQAALVELHSMEVILNDSEEQEEMRSFSGPLIREDVHKVDIMTFCQQKAA    281 - 350
QSCKSETLGSRDSALLWQLLVLLCRQNGSMVGSDIAELLMQDCKKLEKYKRQPPVANLINLTDEDWPVLS    351 - 420
SGTPNLLTGEIPPSVETPAQIVEKFTRLLYYGRKKEALEWAMKNHLWGHALFLSSKMDPQTYSWVMSGFT    421 - 490
STLALNDPLQTLFQLMSGRIPQAATCCGEKQWGDWRPHLAVILSNQAGDPELYQRAIVAIGDTLAGKGLV    491 - 560
EAAHFCYLMAHVPFGHYTVKTDHLVLLGSSHSQEFLKFATTEAIQRTEIFEYCQMLGRPKSFIPSFQVYK    561 - 630
LLYASRLADYGLVSQALHYCEAIGAAVLSQGESSHPVLLVELIKLAEKLKLSDPLVLERRSGDRDLEPDW    631 - 700
LAQLRRQLEQKVAGDIGDPHPTRSDISGAGGTTTENTFYQDFSGCQGYSEAPGYRSALWLTPEQTCLLQP    701 - 770
SPQQPFPLQPGSYPAGGGAGQTGTPRPFYSVPETHLPGTGSSVAVTEATGGTVWEEMLQTHLGPGENTVS    771 - 840
QETSQPPDGQEVISKPQTPLAARPRSISESSASSAKEDEKESSDEADKNSPRNTAQRGKLGDGKEHTKSS    841 - 910
GFGWFSWFRSKPTKNASPAGDEDSSDSPDSEETPRASSPHQAGLGLSLTPSPESPPLPDVSAFSRGRGGG    911 - 980
EGRGSASSGGAAAGAGVGGLSGPESVSFELCSNPGVLLPPPALKGAVPLYNPSQVPQLPTATSLNRPNRL    981 - 1050
AQRRYPTQPC                                                               1051 - 1060
//

Text Mined References (37)

PMID Year Title