Tbio SDR16C5 Epidermal retinol dehydrogenase 2

Protein Summary

Description

Oxidoreductase with strong preference for NAD. Active in both the oxidative and reductive directions. Oxidizes all-trans-retinol in all-trans-retinaldehyde. No activity was detected with 11-cis-retinol or 11-cis-retinaldehyde as substrates with either NAD(+)/NADH or NADP(+)/NADPH. This gene encodes a member of the short-chain alcohol dehydrogenase/reductase superfamily of proteins and is involved in the oxidation of retinol to retinaldehyde. The encoded protein is associated with the endoplasmic reticulum and is predicted to contain three transmembrane helices, suggesting that it is an integral membrane protein. It recognizes all-trans-retinol and all-trans-retinaldehyde as substrates and exhibits a strong preference for NAD(+)/NADH as cofactors. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2015]

Uniprot Accession IDs

• Q8N3Y7
• B4DGK2
• Q330K3
• Q8TDV9
• Q96LX1
• EPHD-2

Gene Name

• SDR16C5

Ensembl ID

• ENST00000303749
• ENSP00000307607
• ENSG00000170786
• ENST00000396721
• ENSP00000379947

Symbol

• RDHE2
• RDH#2
• RDHE2
• EPHD-2
• RDH-E2
• retSDR2

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
cellular component	0.66
virus perturbation	0.5
tissue sample	0.49
cell line	0.46
chemical	0.45

Protein Classes

No PANTHER Classes or DTO Classes found

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 10.09   (req: < 5)

Gene RIFs: 3   (req: <= 3)

Antibodies: 114   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 10.09   (req: >= 5)

Gene RIFs: 3   (req: > 3)

Antibodies: 114   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 10

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0