| Tdark | Serologically defined colon cancer antigen 3 |
May be involved in modulation of TNF response. May be involved in presentation of TNFRSF1A on the cell surface (By similarity). Involved in the endosome-to-plasma membrane trafficking and recycling of SNX27-retromer-dependent cargo proteins, such as GLUT1 (PubMed:25278552). Involved in the regulation of cytokinesis; the function may involve PTPN13 and GIT1 (PubMed:23108400).
Comments
| Disease | Target Count | P-value |
|---|---|---|
| ovarian cancer | 8520 | 1.1e-07 |
| glioblastoma | 5792 | 2.1e-07 |
| osteosarcoma | 7950 | 1.9e-06 |
| lung cancer | 4740 | 6.0e-04 |
| psoriasis | 6694 | 9.0e-04 |
| group 3 medulloblastoma | 4104 | 1.0e-03 |
| interstitial lung disease | 298 | 1.2e-02 |
| intraductal papillary-mucinous neoplasm (IPMN) | 3291 | 1.6e-02 |
| intraductal papillary-mucinous adenoma (IPMA) | 2955 | 3.0e-02 |
| Disease | log2 FC | p |
|---|---|---|
| glioblastoma | 1.100 | 2.1e-07 |
| group 3 medulloblastoma | 1.100 | 1.0e-03 |
| interstitial lung disease | 1.100 | 1.2e-02 |
| intraductal papillary-mucinous adenoma (... | 1.100 | 3.0e-02 |
| intraductal papillary-mucinous neoplasm ... | 1.200 | 1.6e-02 |
| lung cancer | 1.300 | 6.0e-04 |
| osteosarcoma | 2.652 | 1.9e-06 |
| ovarian cancer | -1.200 | 1.1e-07 |
| psoriasis | 1.200 | 9.0e-04 |
MSGYQRRPGATPLSRARSLAIPDAPAFYERRSCLPQLNCERPHGRDLDSPFFGIRPAFMCYVPSPVLASV 1 - 70 GDTDFGYGKGKCSKQSPSGAHGTHFGDDRFEDLEEANPFSFREFLKTKNLGLSKEDPASRIYAKEASRHS 71 - 140 LGLDHNSPPSQTGGYGLEYQQPFFEDPTGAGDLLDEEEDEDTGWSGAYLPSAIEQTHPERVPAGTSPCST 141 - 210 YLSFFSTPSELAGPESLPSWALSDTDSRVSPASPAGSPSADFAVHGESLGDRHLRTLQISYDALKDENSK 211 - 280 LRRKLNEVQSFSEAQTEMVRTLERKLEAKMIKEESDYHDLESVVQQVEQNLELMTKRAVKAENHVVKLKQ 281 - 350 EISLLQAQVSNFQRENEALRCGQGASLTVVKQNADVALQNLRVVMNSAQASIKQLVSGAETLNLVAEILK 351 - 420 SIDRISEVKDEEEDS 421 - 435 //
