Protein Summary
Probable transcription factor. This gene encodes a sal-like C2H2-type zinc-finger protein, and belongs to a family of evolutionarily conserved genes found in species as diverse as Drosophila, C. elegans, and vertebrates. Mutations in some of these genes are associated with congenital disorders in human, suggesting their importance in embryonic development. This protein binds to DNA methyltransferase 3 alpha (DNMT3A), and reduces DNMT3A-mediated CpG island methylation. It is suggested that silencing of this gene, resulting in acceleration of DNA methylation, may have a role in oncogenesis. [provided by RefSeq, Oct 2011]
- ENST00000536229
- ENSP00000439975
- ENSG00000256463
- ENST00000537592
- ENSP00000441823
- ENST00000575389
- ENSP00000458360
- ENST00000614883
- ENSP00000478953
- ENSG00000277015
- ENST00000631929
- ENSP00000488140
- ENST00000633643
- ENSP00000488722
- ZNF796
- ZNF796
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
PubMedID | 0.66 | ||
biological process | 0.58 | ||
gene perturbation | 0.58 | ||
cell type or tissue | 0.56 | ||
disease perturbation | 0.56 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 21.11 (req: < 5)
Gene RIFs: 7 (req: <= 3)
Antibodies: 26 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 21.11 (req: >= 5)
Gene RIFs: 7 (req: > 3)
Antibodies: 26 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 8
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligand: 0
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0