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Tbio
RSBN1
Lysine-specific demethylase 9

Protein Summary
Description
Histone demethylase that specifically demethylates dimethylated 'Lys-20' of histone H4 (H4K20me2), thereby modulating chromosome architecture.
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000261441
  • ENSP00000261441
  • ENSG00000081019
  • ENST00000612242
  • ENSP00000479490

Symbol
  • KDM9
  • ROSBIN
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
transcription factor binding site profile
0.95
kinase perturbation
0.91
transcription factor perturbation
0.68
microRNA
0.64
disease perturbation
0.62


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 6.6   (req: < 5)
Gene RIFs: 3   (req: <= 3)
Antibodies: 105   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 6.6   (req: >= 5)
Gene RIFs: 3   (req: > 3)
Antibodies: 105   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 3
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0