RING finger protein 219

Property Summary

NCBI Gene PubMed Count	10
PubMed Score	1.39

PubTator Score	1.17

Knowledge Summary

Patent

No data available

TINX Plot

Disease (2)

Expression Atlas
JensenLab Experiment COSMIC

Disease	Target Count	P-value
malignant mesothelioma	3232	2.9e-06
dermatomyositis	966	1.4e-03
tuberculosis	2010	3.5e-03
sonic hedgehog group medulloblastoma	467	4.3e-03
lung cancer	4740	6.1e-03
psoriasis	6694	1.4e-02
intraductal papillary-mucinous neoplasm (IPMN)	3291	2.7e-02

Disease	Target Count	Z-score	Confidence
Carcinoma	11493	0.0	0.7

Differential Expression (7)

Disease	log2 FC	p
dermatomyositis	1.100	1.4e-03
intraductal papillary-mucinous neoplasm ...	1.700	2.7e-02
lung cancer	1.200	6.1e-03
malignant mesothelioma	1.300	2.9e-06
psoriasis	-1.200	1.4e-02
sonic hedgehog group medulloblastoma	1.300	4.3e-03
tuberculosis	-1.100	3.5e-03

Brain - Cerebellar Hemisphere 18,015

Cells - EBV-transformed lymphocytes 18,186

Testis 18,518

Brain - Cerebellum 17,983

Spleen 17,614

Uterus 17,618

Cells - Transformed fibroblasts 17,577

Nerve - Tibial 18,007

Brain - Frontal Cortex (BA9) 18,069

Ovary 17,971

Small Intestine - Terminal Ileum 17,954

Vagina 17,834

Adipose - Subcutaneous 18,110

Adipose - Visceral (Omentum) 17,937

Breast - Mammary Tissue 18,103

Skin - Not Sun Exposed (Suprapubic) 18,081

Colon - Sigmoid 18,089

Thyroid 18,024

Skin - Sun Exposed (Lower leg) 17,968

Prostate 18,213

Brain - Anterior cingulate cortex (BA24) 17,989

Brain - Nucleus accumbens (basal ganglia... 18,024

Esophagus - Muscularis 18,017

Esophagus - Gastroesophageal Junction 18,000

Brain - Hypothalamus 18,169

Pituitary 18,147

Artery - Coronary 17,949

Artery - Tibial 17,631

Esophagus - Mucosa 18,076

Brain - Spinal cord (cervical c-1) 17,973

Brain - Caudate (basal ganglia) 18,001

Brain - Hippocampus 18,011

Brain - Amygdala 18,006

Lung 18,057

Brain - Cortex 18,039

Artery - Aorta 17,896

Colon - Transverse 17,825

Minor Salivary Gland 18,005

Adrenal Gland 18,071

Brain - Putamen (basal ganglia) 17,863

Stomach 17,879

Brain - Substantia nigra 17,981

Heart - Atrial Appendage 17,896

Liver 18,071

Muscle - Skeletal 17,778

Heart - Left Ventricle 18,006

Kidney - Cortex 17,329

Pancreas 18,123

Whole Blood 17,439

Adult Testis 10,836

Adult Liver 9,113

B Cells 9,086

Adult Retina 10,115

Adult Kidney 6,723

Fetal Ovary 9,118

Adult Pancreas 9,168

Fetal Brain 7,866

CD8 Cells 9,840

Adult Frontal Cortex 9,048

Brain

Frontal lobe

Kidney

Liver

B-lymphocyte

Ovary

Pancreas

Retina

Testis

BTO:0004410

adipose tissue 15,837

adrenal gland 15,963

appendix 16,247

bone marrow 14,571

breast 16,063

cerebral cortex 16,630

cervix, uterine 15,871

colon 15,959

duodenum 15,975

endometrium 16,349

epididymis 15,863

esophagus 15,898

fallopian tube 16,245

gallbladder 16,333

heart muscle 14,972

kidney 15,917

liver 14,587

lung 16,312

lymph node 15,833

ovary 15,408

pancreas 14,070

parathyroid gland 14,769

placenta 15,937

prostate 16,460

rectum 15,705

salivary gland 14,981

seminal vesicle 15,918

skeletal muscle 14,011

skin 16,206

small intestine 16,154

smooth muscle 15,857

spleen 15,972

stomach 16,099

testis 17,936

thyroid gland 15,959

tonsil 15,400

urinary bladder 15,814

Liver and Pancreas 16,750

Digestive Tract 17,369

Urinary Tract 16,678

Endocrine System 18,159

Blood and immune system 16,909

Respiratory system 16,393

Female tissues 17,400

Male tissues 17,142

Skin and soft tissues 17,230

Nervous System 16,725

Cardiovascular System 15,192

Brain 7,346

Cervical carcinoma cell 4,944

Erythroleukemia cell 4,300

Placenta 3,079

Testis 3,897

Pronephros 717

T-cell chronic lymphocytic leukemia cell 2,346

See source...

SGS cell 45

See source...

Synonym

Accession	Q5W0B1 B2RN99 Q8TBY2 Q9H0T2 Q9H8M0
Symbols	C13orf7

Gene

RNF219

Ortholog (13)

Species	Source	Disease
Anole lizard 10,588	Inparanoid OMA EggNOG
Chicken 7,827	Inparanoid OMA EggNOG
Xenopus 10,468	Inparanoid EggNOG
Macaque 12,761	Inparanoid OMA EggNOG
Chimp 14,140	OMA EggNOG
Rat 15,117	Inparanoid OMA EggNOG
Mouse 16,570	Inparanoid OMA EggNOG
Horse 14,252	Inparanoid OMA EggNOG
Dog 15,073	Inparanoid OMA EggNOG
Pig 10,168	OMA EggNOG
Cow 15,320	Inparanoid OMA EggNOG
Platypus 5,703	Inparanoid OMA EggNOG
Opossum 12,230	Inparanoid OMA EggNOG

UniProt Keyword (7)

Complete proteome 20,231

Metal-binding 3,672

Reference proteome 20,231

Zinc 2,356

Zinc-finger 1,785

Phosphoprotein 8,216

Coiled coil 2,153

GO Function (1)

metal ion binding 2,256

Compartment GO Term (6)

CCR4-NOT complex 33

Cytosol 6,686

Nuclear bodies 450

Nucleoplasm 5,077

Protein phosphatase 4 complex 13

cellular_component 18,320

GWAS Trait (9)

Night sleep phenotypes 123

Large artery stroke 12

Squamous cell lung carcinoma 71

Urinary tract infection frequency 39

Total ventricular volume (Alzheimer's di... 7

Serum thyroid-stimulating hormone levels 14

Facial morphology (factor 17, height of ... 10

Diastolic blood pressure (alcohol consum... 3

Juvenile osteochondritis dissecans 4

HCA RNA Cell Line (56)

A-431 16,131

A549 15,174

AF22 16,160

AN3-CA 15,648

ASC TERT1 14,842

BEWO 16,726

BJ 15,448

BJ hTERT+ 15,353

BJ hTERT+ SV40 Large T+ 15,609

BJ hTERT+ SV40 Large T+ RasG12V 15,493

See all...

AA Sequence

MAQTVQNVTLSLTLPITCHICLGKVRQPVICINNHVFCSICIDLWLKNNSQCPACRVPITPENPCKEIIG      1 - 70
GTSESEPMLSHTVRKHLRKTRLELLHKEYEDEIDCLQKEVEELKSKNLSLESQIKTILDPLTLVQGNQNE     71 - 140
DKHLVTDNPSKINPETVAEWKKKLRTANEIYEKVKDDVDKLKEANKKLKLENGGLVRENLRLKAEVDNRS    141 - 210
PQKFGRFAVAALQSKVEQYERETNRLKKALERSDKYIEELESQVAQLKNSSEEKEAMNSICQTALSADGK    211 - 280
GSKGSEEDVVSKNQGDSARKQPGSSTSSSSHLAKPSSSRLCDTSSARQESTSKADLNCSKNKDLYQEQVE    281 - 350
VMLDVTDTSMDTYLEREWGNKPSDCVPYKDEELYDLPAPCTPLSLSCLQLSTPENRESSVVQAGGSKKHS    351 - 420
NHLRKLVFDDFCDSSNVSNKDSSEDDISRSENEKKSECFSSPKTGFWDCCSTSYAQNLDFESSEGNTIAN    421 - 490
SVGEISSKLSEKSGLCLSKRLNSIRSFEMNRTRTSSEASMDAAYLDKISELDSMMSESDNSKSPCNNGFK    491 - 560
SLDLDGLSKSSQGSEFLEEPDKLEEKTELNLSKGSLTNDQLENGSEWKPTSFFLLSPSDQEMNEDFSLHS    561 - 630
SSCPVTNEIKPPSCLFQTEFSQGILLSSSHRLFEDQRFGSSLFKMSSEMHSLHNHLQSPWSTSFVPEKRN    631 - 700
KNVNQSTKRKIQSSLSSASPSKATKS                                                701 - 726
//

Text Mined References (17)

Summary
Details

	PMID	Year	Title

Tdark RING finger protein 219 Add to cart View Collections Empty Collection