Tbio Synembryn-B

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Guanine nucleotide exchange factor (GEF), which can activate some, but not all, G-alpha proteins by exchanging bound GDP for free GTP. Able to potentiate G(olf)-alpha-dependent cAMP accumulation suggesting that it may be an important component for odorant signal transduction.

Comments

Property Summary

NCBI Gene PubMed Count	12
PubMed Score	50.11

PubTator Score	10.41

Knowledge Summary

Patent

No data available

TINX Plot

Disease	Target Count	Z-score	Confidence
Carcinoma	11493	0.0	0.8

Disease	Target Count	Z-score	Confidence
Olfactory neuroblastoma	4	3.2	1.6

Expression

Specificity
Differential

Brain - Caudate (basal ganglia) 18,001

Brain - Cerebellar Hemisphere 18,015

Brain - Cerebellum 17,983

Thyroid 18,024

Uterus 17,618

Nerve - Tibial 18,007

Brain - Nucleus accumbens (basal ganglia... 18,024

Pituitary 18,147

Brain - Putamen (basal ganglia) 17,863

Spleen 17,614

Artery - Tibial 17,631

Ovary 17,971

Artery - Coronary 17,949

Colon - Sigmoid 18,089

Testis 18,518

Vagina 17,834

Adipose - Subcutaneous 18,110

Prostate 18,213

Artery - Aorta 17,896

Adipose - Visceral (Omentum) 17,937

Breast - Mammary Tissue 18,103

Esophagus - Gastroesophageal Junction 18,000

Brain - Frontal Cortex (BA9) 18,069

Esophagus - Muscularis 18,017

Brain - Cortex 18,039

Brain - Hypothalamus 18,169

Adrenal Gland 18,071

Cells - Transformed fibroblasts 17,577

Stomach 17,879

Brain - Spinal cord (cervical c-1) 17,973

Cells - EBV-transformed lymphocytes 18,186

Brain - Substantia nigra 17,981

Brain - Anterior cingulate cortex (BA24) 17,989

Small Intestine - Terminal Ileum 17,954

Brain - Hippocampus 18,011

Skin - Not Sun Exposed (Suprapubic) 18,081

Skin - Sun Exposed (Lower leg) 17,968

Heart - Atrial Appendage 17,896

Minor Salivary Gland 18,005

Brain - Amygdala 18,006

Kidney - Cortex 17,329

Muscle - Skeletal 17,778

Pancreas 18,123

Liver 18,071

Colon - Transverse 17,825

Lung 18,057

Esophagus - Mucosa 18,076

Heart - Left Ventricle 18,006

Whole Blood 17,439

Adult Testis 10,836

Adult Liver 9,113

CD8 Cells 9,840

Adult Lung 6,663

Fetal Ovary 9,118

Adult Adrenal 8,475

Adult Retina 10,115

Adult Gallbladder 7,612

Adult Prostate 8,952

Fetal Brain 7,866

Adult Heart 6,506

Adult Pancreas 9,168

CD4 Cells 7,773

Fetal Heart 9,228

B Cells 9,086

Adult Rectum 8,022

NK Cells 8,475

Adult Ovary 10,192

Adult Frontal Cortex 9,048

Adult Colon 7,915

Adult Spinal Cord 7,594

Fetal Liver 8,402

Adult Urinary Bladder 7,592

Fetal Testis 7,955

Platelets 6,131

Adrenal gland

Blood platelet

Brain

Colon

Frontal lobe

Gall bladder

Heart

Liver

Lung

B-lymphocyte

Natural killer cell

Ovary

Pancreas

Placenta 6,083

Prostate gland

Retina

Spinal cord

Testis

Urinary bladder

BTO:0004410

BTO:0005453

adipose tissue 15,837

adrenal gland 15,963

appendix 16,247

bone marrow 14,571

breast 16,063

cerebral cortex 16,630

cervix, uterine 15,871

colon 15,959

duodenum 15,975

endometrium 16,349

epididymis 15,863

esophagus 15,898

fallopian tube 16,245

gallbladder 16,333

heart muscle 14,972

kidney 15,917

liver 14,587

lung 16,312

lymph node 15,833

ovary 15,408

pancreas 14,070

parathyroid gland 14,769

placenta 15,937

prostate 16,460

rectum 15,705

salivary gland 14,981

seminal vesicle 15,918

skeletal muscle 14,011

skin 16,206

small intestine 16,154

smooth muscle 15,857

spleen 15,972

stomach 16,099

testis 17,936

thyroid gland 15,959

tonsil 15,400

urinary bladder 15,814

Liver and Pancreas 16,750

Digestive Tract 17,369

Urinary Tract 16,678

Endocrine System 18,159

Blood and immune system 16,909

Respiratory system 16,393

Female tissues 17,400

Male tissues 17,142

Skin and soft tissues 17,230

Nervous System 16,725

Cardiovascular System 15,192

Brain 7,346

Teratocarcinoma cell 604

Testis 3,897

T-cell chronic lymphocytic leukemia cell 2,346

See source...

Neuron 779

Olfactory epithelium 34

See source...

Synonym

Accession	Q9NVN3 A2RTZ0 Q4G103 Q6ZRN4 Q86WD3
Symbols	RIC8 hSyn

Gene

RIC8B

Ortholog (15)

Species	Source	Disease
Chimp 14,140	OMA EggNOG
Mouse 16,570	Inparanoid OMA EggNOG
Macaque 12,761	OMA EggNOG
Dog 15,073	Inparanoid OMA EggNOG
Rat 15,117	Inparanoid OMA EggNOG
Cow 15,320	Inparanoid OMA EggNOG
Horse 14,252	Inparanoid OMA EggNOG
Opossum 12,230	Inparanoid OMA EggNOG
Pig 10,168	Inparanoid OMA EggNOG
Anole lizard 10,588	Inparanoid OMA
Platypus 5,703	OMA EggNOG
Zebrafish 9,726	Inparanoid OMA
Xenopus 10,468	OMA EggNOG
Fruitfly 3,050	Inparanoid EggNOG
C. elegans 3,179	Inparanoid OMA EggNOG

UniProt Keyword (6)

Complete proteome 20,231

Reference proteome 20,231

Alternative splicing 10,528

Cytoplasm 4,952

Phosphoprotein 8,216

Guanine-nucleotide releasing factor 150

GO Function (3)

GTPase activator activity 281

guanyl-nucleotide exchange factor activi... 106

G-protein alpha-subunit binding 19

GO Component (4)

centrosome 427

cytosol 4,834

plasma membrane 4,414

cell cortex 118

GO Process (1)

regulation of G-protein coupled receptor... 40

Compartment GO Term (31)

Cell 16,178

Cell cortex 223

Cell part 16,177

Cell periphery 5,382

Centrosome 696

Cytoplasm 10,983

Cytoplasmic part 9,247

Cytoplasmic region 228

Cytoplasmic side of membrane 217

Cytoplasmic side of plasma membrane 194

Cytoskeletal part 1,637

Cytoskeleton 2,108

Cytosol 6,686

Extrinsic component of cytoplasmic side ... 141

Extrinsic component of plasma membrane 176

See all...

IMPC Phenotype (2)

preweaning lethality, complete penetranc... 979

increased leukocyte cell number 47

MGI Phenotype (12)

growth-size-body region phenotype 4,157

cellular phenotype 3,637

craniofacial phenotype 1,182

nervous system phenotype 3,447

hematopoietic system phenotype 3,383

cardiovascular system phenotype 2,660

mortality-aging 5,018

respiratory system phenotype 1,390

skeleton phenotype 2,222

renal-urinary system phenotype 1,269

See all...

GWAS Trait (2)

Triglyceride levels 53

Social autistic-like traits 5

HCA RNA Cell Line (56)

A-431 16,131

A549 15,174

AF22 16,160

AN3-CA 15,648

ASC TERT1 14,842

BEWO 16,726

BJ 15,448

BJ hTERT+ 15,353

BJ hTERT+ SV40 Large T+ 15,609

BJ hTERT+ SV40 Large T+ RasG12V 15,493

See all...

Protein-protein Interaction (1)

GNAS

Gene RIF (5)

AA Sequence

MDEERALYIVRAGEAGAIERVLRDYSDKHRATFKFESTDEDKRKKLCEGIFKVLIKDIPTTCQVSCLEVL      1 - 70
RILSRDKKVLVPVTTKENMQILLRLAKLNELDDSLEKVSEFPVIVESLKCLCNIVFNSQMAQQLSLELNL     71 - 140
AAKLCNLLRKCKDRKFINDIKCFDLRLLFLLSLLHTDIRSQLRYELQGLPLLTQILESAFSIKWTDEYES    141 - 210
AIDHNGPPLSPQETDCAIEALKALFNVTVDSWKVHKESDSHQFRVMAAVLRHCLLIVGPTEDKTEELHSN    211 - 280
AVNLLSNVPVSCLDVLICPLTHEETAQEATTLDELPSNKTAEKETVLKNNTMVYNGMNMEAIHVLLNFME    281 - 350
KRIDKGSSYREGLTPVLSLLTECSRAHRNIRKFLKDQVLPPLRDVTNRPEVGSTVRNKLVRLMTHVDLGV    351 - 420
KQIAAEFLFVLCKERVDSLLKYTGYGNAAGLLAARGLLAGGRGDNWYSEDEDTDTEEYKNAKPKEELLKP    421 - 490
MGLKPDGTITPLEEALNQYSVIEETSSDTD                                            491 - 520
//

Text Mined References (14)

Summary
Details

	PMID	Year	Title

Tbio Synembryn-B Add to cart View Collections Empty Collection

Property Summary

Knowledge Summary

Patent

No data available

TINX Plot

Disease (2)

Expression

Synonym

Gene

Ortholog (15)

UniProt Keyword (6)

GO Function (3)

GO Component (4)

GO Process (1)

Compartment GO Term (31)

IMPC Phenotype (2)

MGI Phenotype (12)

GWAS Trait (2)

HCA RNA Cell Line (56)

Protein-protein Interaction (1)

Gene RIF (5)

AA Sequence

Text Mined References (14)

Tbio Synembryn-B

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