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Tbio Synembryn-B

Guanine nucleotide exchange factor (GEF), which can activate some, but not all, G-alpha proteins by exchanging bound GDP for free GTP. Able to potentiate G(olf)-alpha-dependent cAMP accumulation suggesting that it may be an important component for odorant signal transduction.

 Comments

Property Summary

NCBI Gene PubMed Count 12
PubMed Score 50.11
PubTator Score 10.41

Knowledge Summary

Patent

No data available

TINX Plot

  Disease (2)

Disease Target Count Z-score Confidence
Carcinoma 11493 0.0 0.8
Disease Target Count Z-score Confidence
Olfactory neuroblastoma 4 3.2 1.6

Expression

Synonym

Accession Q9NVN3 A2RTZ0 Q4G103 Q6ZRN4 Q86WD3
Symbols RIC8
hSyn

Gene

RIC8B

  Ortholog (1)

Species Source Disease
Chimp OMA EggNOG

 UniProt Keyword (6)

 GO Function (3)

 GO Component (4)

 GO Process (1)

 Compartment GO Term (31)

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 IMPC Phenotype (2)

 MGI Phenotype (12)

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 GWAS Trait (2)

 HCA RNA Cell Line (56)

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Protein-protein Interaction (1)

GNAS  

Gene RIF (5)

AA Sequence 

MDEERALYIVRAGEAGAIERVLRDYSDKHRATFKFESTDEDKRKKLCEGIFKVLIKDIPTTCQVSCLEVL      1 - 70
RILSRDKKVLVPVTTKENMQILLRLAKLNELDDSLEKVSEFPVIVESLKCLCNIVFNSQMAQQLSLELNL     71 - 140
AAKLCNLLRKCKDRKFINDIKCFDLRLLFLLSLLHTDIRSQLRYELQGLPLLTQILESAFSIKWTDEYES    141 - 210
AIDHNGPPLSPQETDCAIEALKALFNVTVDSWKVHKESDSHQFRVMAAVLRHCLLIVGPTEDKTEELHSN    211 - 280
AVNLLSNVPVSCLDVLICPLTHEETAQEATTLDELPSNKTAEKETVLKNNTMVYNGMNMEAIHVLLNFME    281 - 350
KRIDKGSSYREGLTPVLSLLTECSRAHRNIRKFLKDQVLPPLRDVTNRPEVGSTVRNKLVRLMTHVDLGV    351 - 420
KQIAAEFLFVLCKERVDSLLKYTGYGNAAGLLAARGLLAGGRGDNWYSEDEDTDTEEYKNAKPKEELLKP    421 - 490
MGLKPDGTITPLEEALNQYSVIEETSSDTD                                            491 - 520
//

Text Mined References (14)

PMID Year Title