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Tclin Receptor activity-modifying protein 1

Transports the calcitonin gene-related peptide type 1 receptor (CALCRL) to the plasma membrane. Acts as a receptor for calcitonin-gene-related peptide (CGRP) together with CALCRL.

The protein encoded by this gene is a member of the RAMP family of single-transmembrane-domain proteins, called receptor (calcitonin) activity modifying proteins (RAMPs). RAMPs are type I transmembrane proteins with an extracellular N terminus and a cytoplasmic C terminus. RAMPs are required to transport calcitonin-receptor-like receptor (CRLR) to the plasma membrane. CRLR, a receptor with seven transmembrane domains, can function as either a calcitonin-gene-related peptide (CGRP) receptor or an adrenomedullin receptor, depending on which members of the RAMP family are expressed. In the presence of this (RAMP1) protein, CRLR functions as a CGRP receptor. The RAMP1 protein is involved in the terminal glycosylation, maturation, and presentation of the CGRP receptor to the cell surface. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Apr 2015]

 Comments

Property Summary

Ligand Count 1
NCBI Gene PubMed Count 56
PubMed Score 148.47
PubTator Score 78.57

Knowledge Summary

Patent

No data available

TINX Plot

  Disease (4)

Disease Target Count Z-score Confidence
Liver Cirrhosis, Experimental 769 0.0 0.0
Disease Target Count Z-score Confidence
Migraine 83 5.808 2.9
Hypertension 396 3.321 1.7

Expression

  Differential Expression (14)

Disease log2 FC p
active ulcerative colitis 1.897 8.2e-03
atypical teratoid / rhabdoid tumor -2.600 1.4e-05
breast carcinoma 1.700 5.4e-03
group 3 medulloblastoma -1.400 2.7e-03
interstitial cystitis 1.600 2.4e-03
intraductal papillary-mucinous adenoma (... -2.400 5.1e-04
intraductal papillary-mucinous carcinoma... -1.900 6.9e-03
intraductal papillary-mucinous neoplasm ... -1.600 3.1e-02
lung adenocarcinoma 2.200 8.7e-08
malignant mesothelioma -1.100 4.5e-06
medulloblastoma, large-cell -1.600 6.1e-04
osteosarcoma 1.041 1.6e-02
ovarian cancer -1.300 3.8e-07
primitive neuroectodermal tumor -1.500 9.0e-03

Synonym

Accession O60894 Q6FGS5
Symbols

Gene

RAMP1

PANTHER Protein Class (1)

  Ortholog (10)

Species Source Disease
Inparanoid OMA EggNOG
Inparanoid OMA EggNOG
Inparanoid OMA EggNOG
OMA EggNOG
Inparanoid OMA EggNOG
Inparanoid EggNOG
Inparanoid OMA EggNOG
Inparanoid OMA EggNOG
Inparanoid OMA EggNOG
Inparanoid OMA EggNOG

 UniProt Keyword (10)

 GO Function (5)

 GO Component (7)

 GO Process (12)

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 Compartment GO Term (25)

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 IMPC Phenotype (3)

 MGI Phenotype (5)

 GWAS Trait (4)

 HCA RNA Cell Line (46)

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Pathway (10)

Protein-protein Interaction (18)

GRAMD1A   SGPL1   SLC30A1   NETO2   ADGRL1   CCPG1   ADCY9   DNAJB9   SLC12A7   POMT2   MANBA   FZD2   FZD6   GLRB   CALCRL   SELENOS   KCNJ8   RHBDD1  

PDB (5)

Drug (1)

Structure of pramlintide

pramlintide
pEC50 9.45

Gene RIF (34)

AA Sequence 

MARALCRLPRRGLWLLLAHHLFMTTACQEANYGALLRELCLTQFQVDMEAVGETLWCDWGRTIRSYRELA      1 - 70
DCTWHMAEKLGCFWPNAEVDRFFLAVHGRYFRSCPISGRAVRDPPGSILYPFIVVPITVTLLVTALVVWQ     71 - 140
SKRTEGIV                                                                  141 - 148
//

Text Mined References (56)

PMID Year Title