| Tdark | Retinoic acid-induced protein 2 |
Retinoic acid plays a critical role in development, cellular growth, and differentiation. The specific function of this retinoic acid-induced gene has not yet been determined but it may play a role in development. The chromosomal location of this gene designates it to be a candidate for diseases such as Nance-Horan syndrome, sensorineural deafness, non-specific X-linked cognitive disability, oral-facial-digital syndrome, and Fried syndrome. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Feb 2010]
Comments
| Disease | Target Count | P-value |
|---|---|---|
| non-small cell lung cancer | 2890 | 1.7e-27 |
| lung adenocarcinoma | 2716 | 4.9e-11 |
| psoriasis | 6694 | 2.1e-08 |
| lung cancer | 4740 | 1.6e-04 |
| adrenocortical carcinoma | 1428 | 2.1e-04 |
| atypical teratoid / rhabdoid tumor | 5112 | 4.0e-04 |
| glioblastoma | 5792 | 4.3e-04 |
| Breast cancer | 3578 | 5.4e-04 |
| adult high grade glioma | 3801 | 7.0e-04 |
| Atopic dermatitis | 952 | 7.8e-04 |
| ulcerative colitis | 1819 | 4.9e-03 |
| ductal carcinoma in situ | 1745 | 7.7e-03 |
| group 4 medulloblastoma | 1855 | 7.7e-03 |
| colon cancer | 1478 | 1.0e-02 |
| intraductal papillary-mucinous neoplasm (IPMN) | 3291 | 1.5e-02 |
| intraductal papillary-mucinous carcinoma (IPMC) | 2989 | 1.5e-02 |
| invasive ductal carcinoma | 2951 | 2.2e-02 |
| active Crohn's disease | 922 | 2.8e-02 |
| Disease | Target Count | Z-score | Confidence |
|---|---|---|---|
| Nance-Horan syndrome | 25 | 6.414 | 3.2 |
| Disease | log2 FC | p |
|---|---|---|
| active Crohn's disease | 1.476 | 2.8e-02 |
| adrenocortical carcinoma | -2.000 | 2.1e-04 |
| adult high grade glioma | -1.100 | 7.0e-04 |
| Atopic dermatitis | -1.400 | 7.8e-04 |
| atypical teratoid / rhabdoid tumor | -1.900 | 4.0e-04 |
| Breast cancer | -1.800 | 5.4e-04 |
| colon cancer | -2.300 | 1.0e-02 |
| ductal carcinoma in situ | -1.400 | 7.7e-03 |
| glioblastoma | -1.200 | 4.3e-04 |
| group 4 medulloblastoma | -1.200 | 7.7e-03 |
| intraductal papillary-mucinous carcinoma... | -1.600 | 1.5e-02 |
| intraductal papillary-mucinous neoplasm ... | -1.400 | 1.5e-02 |
| invasive ductal carcinoma | -1.900 | 2.2e-02 |
| lung adenocarcinoma | -1.700 | 4.9e-11 |
| lung cancer | -2.700 | 1.6e-04 |
| non-small cell lung cancer | -2.366 | 1.7e-27 |
| psoriasis | -2.100 | 2.1e-08 |
| ulcerative colitis | 1.100 | 4.9e-03 |
MDDLQSQNLSMDMTDSPPALANNRLENGMAQLITTEAWNINSTDLVKKALVTVPAPSILNPPAESQSGMA 1 - 70 LKVAATVLQPLCLGESPVVMPIHMQVEGSSAPELNPNGNATYVMTTQGPVQLPVVLEQHVFQHLNSPLVL 71 - 140 PQEAPCSSSTIHNNLFQGAEDPEAQPQLLDLRIPSQPQEPTLPFEAVLQNLFPSQGTLGPPPCQPPPGYA 141 - 210 PVPPQPFSSPLSPLVPPATLLVPYPVIVPLPVPVPIPIPIPMPQSSESKFSSSFPKPPSSFGLHPFKGTQ 211 - 280 TPLEKDELKPFDILQPKEYFQLSRHTVIKMGSENEALDLSMKSVPWLKAGEVSPPIFQEDAALDLSVAAH 281 - 350 RKSEPPPETLYDSGASVDSSGHTVMEKLPSGMEISFAPATSHEAPAMMDSHISSSDAATEMLSQPNHPSG 351 - 420 EVKAENNIEMVGESQAAKVIVSVEDAVPTIFCGKIKGLSGVSTKNFSFKREDSVLQGYDINSQGEESMGN 421 - 490 AEPLRKPIKNRSIKLKKVNSQEIHMLPIKKQRLATFFPRK 491 - 530 //
