| Tbio | Rab11 family-interacting protein 2 |
A Rab11 effector binding preferentially phosphatidylinositol 3,4,5-trisphosphate (PtdInsP3) and phosphatidic acid (PA) and acting in the regulation of the transport of vesicles from the endosomal recycling compartment (ERC) to the plasma membrane. Involved in insulin granule exocytosis. Also involved in receptor-mediated endocytosis and membrane trafficking of recycling endosomes, probably originating from clathrin-coated vesicles. Required in a complex with MYO5B and RAB11 for the transport of NPC1L1 to the plasma membrane. Also acts as a regulator of cell polarity.
Comments
| Disease | Target Count | P-value |
|---|---|---|
| non-small cell lung cancer | 2890 | 4.0e-16 |
| glioblastoma | 5792 | 6.4e-06 |
| atypical teratoid / rhabdoid tumor | 5112 | 7.5e-06 |
| ependymoma | 4679 | 1.1e-05 |
| ovarian cancer | 8520 | 5.4e-05 |
| primitive neuroectodermal tumor | 3035 | 2.5e-04 |
| adult high grade glioma | 3801 | 4.8e-04 |
| group 4 medulloblastoma | 1855 | 1.7e-03 |
| osteosarcoma | 7950 | 1.7e-03 |
| lung cancer | 4740 | 3.5e-03 |
| Breast cancer | 3578 | 2.3e-02 |
| gastric carcinoma | 807 | 2.4e-02 |
| acute myeloid leukemia | 783 | 2.7e-02 |
| Disease | log2 FC | p |
|---|---|---|
| acute myeloid leukemia | 1.300 | 2.7e-02 |
| adult high grade glioma | -1.500 | 4.8e-04 |
| atypical teratoid / rhabdoid tumor | -1.500 | 7.5e-06 |
| Breast cancer | 3.000 | 2.3e-02 |
| ependymoma | -1.200 | 1.1e-05 |
| gastric carcinoma | -1.500 | 2.4e-02 |
| glioblastoma | -1.300 | 6.4e-06 |
| group 4 medulloblastoma | -1.500 | 1.7e-03 |
| lung cancer | 2.500 | 3.5e-03 |
| non-small cell lung cancer | -1.094 | 4.0e-16 |
| osteosarcoma | -1.105 | 1.7e-03 |
| ovarian cancer | -1.500 | 5.4e-05 |
| primitive neuroectodermal tumor | -1.100 | 2.5e-04 |
MMLSEQAQKWFPTHVQVTVLQAKDLKPKGKSGTNDTYTIIQLGKEKYSTSVAEKTLEPVWKEEASFELPG 1 - 70 LLIQGSPEKYILFLIVMHRSLVGLDKFLGQVAINLNDIFEDKQRRKTEWFRLESKQGKRIKNRGEIKVNI 71 - 140 QFMRNNMTASMFDLSMKDKTRSPFAKLKDKMKGRKNDGTFSDTSSAIIPSTHMPDANSEFSSGEIQMKSK 141 - 210 PKKPFLLGPQRLSSAHSMSDLSGSHMSSEKLKAGTIGQTHLLGHQLDSFGTVPESGSLKSPHRRTLSFDT 211 - 280 SKMNQPDSIVDEGELCFGRQNDPFTNVTASLPQKFATLPRKKNPFEESSETWDSSMNLFSKPIEIRKENK 281 - 350 REKREKVSLFERVTGKKDSRRSDKLNNGGSDSPCDLKSPNAFSENRQDYFDYESTNPFTAKFRASNIMPS 351 - 420 SSFHMSPTSNEDLRKIPDSNPFDATAGYRSLTYEEVLQELVKHKELLRRKDTHIRELEDYIDNLLVRVME 421 - 490 ETPSILRVPYEPSRKAGKFSNS 491 - 512 //
