Property Summary

NCBI Gene PubMed Count 31
PubMed Score 14.72
PubTator Score 70.97

Knowledge Summary

Patent

No data available

TINX Plot

  Disease Sources (3)

Disease Target Count P-value
non-small cell lung cancer 2798 2.73215992242292E-10
acute quadriplegic myopathy 1157 1.80265654237162E-8
tuberculosis 1563 1.08960664340347E-6
group 3 medulloblastoma 2254 2.6616710277117E-6
medulloblastoma, large-cell 6234 5.27406382213998E-6
Pick disease 1893 9.16201298634003E-6
atypical teratoid / rhabdoid tumor 4369 1.59351173771618E-4
ductal carcinoma in situ 1745 3.46734774299872E-4
non diabetic and post-ischemic heart failure 200 0.00333374275772841
invasive ductal carcinoma 2950 0.00727386536794404
Alzheimer's disease 644 0.0185865787017585
spina bifida 1064 0.0371974579388506
Hydrolethalus syndrome 128 0.0477421870616505
Disease Target Count Z-score Confidence
Lipid storage disease 7 0.0 2.0
Disease Target Count Z-score Confidence
Heroin dependence 30 3.539 1.8

Expression

  Differential Expression (13)

Synonym

Accession Q9Y5Q0 O60426
Symbols CYB5RP
LLCDL3

Gene

  Ortholog (10)

 GWAS Trait (1)

Pathway (1)

Gene RIF (15)

PMID Text
24985009 Minor allele homozygotes and heterozygotes of rs174455 in FADS3 gene had lower levels of 22:5 omega-3, 20:4 omega-6, and Delta5desaturase activity in patients with type 2 diabetes mellitus.
22877655 genetic association study in maternal/child dyads in England: Data suggest that SNPs in FADS3 (and in FADS1/FADS2) influence fetal fatty acid metabolism; both maternal and child FADS genotypes/haplotypes influence cord plasma long-chain fatty acids.
22398025 Data suggest that FADS3 alternative transcripts/splicing are up-regulated in liver by dietary docosahexaenoic/arachidonic acids by peroxisome proliferator-activated receptor gamma (PPARg)-dependent mechanism unrelated to other desaturases (FADS1/2).
22082156 Knockdown of fatty acid desaturase 3 (FADS3) by siRNA enhances the early stages of HIV-1 replication in HeLa-CD4 cells infected with viral pseudotypes HIV89.6R and HIV8.2N
21366865 it is highly likely that a gene product of FADS3 has desaturating activity.
21040914 Observational study of gene-disease association. (HuGE Navigator)
20972250 Observational study of gene-disease association. (HuGE Navigator)
20628086 Observational study of gene-disease association, gene-environment interaction, and pharmacogenomic / toxicogenomic. (HuGE Navigator)
20562440 Observational study of gene-disease association. (HuGE Navigator)
19913121 Observational study of gene-disease association. (HuGE Navigator)
More...

AA Sequence

MGGVGEPGPREGPAQPGAPLPTFCWEQIRAHDQPGDKWLVIERRVYDISRWAQRHPGGSRLIGHHGAEDA      1 - 70
TDAFRAFHQDLNFVRKFLQPLLIGELAPEEPSQDGPLNAQLVEDFRALHQAAEDMKLFDASPTFFAFLLG     71 - 140
HILAMEVLAWLLIYLLGPGWVPSALAAFILAISQAQSWCLQHDLGHASIFKKSWWNHVAQKFVMGQLKGF    141 - 210
SAHWWNFRHFQHHAKPNIFHKDPDVTVAPVFLLGESSVEYGKKKRRYLPYNQQHLYFFLIGPPLLTLVNF    211 - 280
EVENLAYMLVCMQWADLLWAASFYARFFLSYLPFYGVPGVLLFFVAVRVLESHWFVWITQMNHIPKEIGH    281 - 350
EKHRDWVSSQLAATCNVEPSLFTNWFSGHLNFQIEHHLFPRMPRHNYSRVAPLVKSLCAKHGLSYEVKPF    351 - 420
LTALVDIVRSLKKSGDIWLDAYLHQ                                                 421 - 445
//

Text Mined References (33)

PMID Year Title
25194280 2014 Genome-wide association study identifies three susceptibility loci for laryngeal squamous cell carcinoma in the Chinese population.
24985009 Genetic variants in desaturase gene, erythrocyte fatty acids, and risk for type 2 diabetes in Chinese Hans.
24823311 2014 Genome-wide association study of plasma N6 polyunsaturated fatty acids within the cohorts for heart and aging research in genomic epidemiology consortium.
24390342 2014 Genetics of rheumatoid arthritis contributes to biology and drug discovery.
24097068 2013 Discovery and refinement of loci associated with lipid levels.
23378610 2013 Genetic variants associated with glycine metabolism and their role in insulin sensitivity and type 2 diabetes.
23362303 2013 Genome-wide association study identifies novel loci associated with concentrations of four plasma phospholipid fatty acids in the de novo lipogenesis pathway: results from the Cohorts for Heart and Aging Research in Genomic Epidemiology (CHARGE) consortium.
22916037 2012 Novel Loci for metabolic networks and multi-tissue expression studies reveal genes for atherosclerosis.
22877655 2013 Umbilical cord PUFA are determined by maternal and child fatty acid desaturase (FADS) genetic variants in the Avon Longitudinal Study of Parents and Children (ALSPAC).
22398025 2013 Dietary long-chain polyunsaturated fatty acids upregulate expression of FADS3 transcripts.
More...