| Tbio | Ubiquitin carboxyl-terminal hydrolase isozyme L5 |
Protease that specifically cleaves 'Lys-48'-linked polyubiquitin chains. Deubiquitinating enzyme associated with the 19S regulatory subunit of the 26S proteasome. Putative regulatory component of the INO80 complex; however is inactive in the INO80 complex and is activated by a transient interaction of the INO80 complex with the proteasome via ADRM1.
Comments
| Disease | Target Count | P-value |
|---|---|---|
| non-small cell lung cancer | 2890 | 4.9e-19 |
| ovarian cancer | 8520 | 5.3e-04 |
| psoriasis | 6694 | 6.3e-04 |
| invasive ductal carcinoma | 2951 | 1.3e-03 |
| hereditary spastic paraplegia | 318 | 3.2e-03 |
| lung cancer | 4740 | 6.1e-03 |
| astrocytic glioma | 2597 | 4.1e-02 |
| oligodendroglioma | 2850 | 4.3e-02 |
| Disease | Target Count | Z-score | Confidence |
|---|---|---|---|
| substance-related disorder | 162 | 0.0 | 1.0 |
| Disease | log2 FC | p |
|---|---|---|
| astrocytic glioma | -1.400 | 4.1e-02 |
| hereditary spastic paraplegia | -1.079 | 3.2e-03 |
| invasive ductal carcinoma | 1.200 | 1.3e-03 |
| lung cancer | 2.300 | 6.1e-03 |
| non-small cell lung cancer | 1.026 | 4.9e-19 |
| oligodendroglioma | -1.400 | 4.3e-02 |
| ovarian cancer | 1.200 | 5.3e-04 |
| psoriasis | 1.100 | 6.3e-04 |
MTGNAGEWCLMESDPGVFTELIKGFGCRGAQVEEIWSLEPENFEKLKPVHGLIFLFKWQPGEEPAGSVVQ 1 - 70 DSRLDTIFFAKQVINNACATQAIVSVLLNCTHQDVHLGETLSEFKEFSQSFDAAMKGLALSNSDVIRQVH 71 - 140 NSFARQQMFEFDTKTSAKEEDAFHFVSYVPVNGRLYELDGLREGPIDLGACNQDDWISAVRPVIEKRIQK 141 - 210 YSEGEIRFNLMAIVSDRKMIYEQKIAELQRQLAEEEPMDTDQGNSMLSAIQSEVAKNQMLIEEEVQKLKR 211 - 280 YKIENIRRKHNYLPFIMELLKTLAEHQQLIPLVEKAKEKQNAKKAQETK 281 - 329 //
