Property Summary

NCBI Gene PubMed Count 14
PubMed Score 5.86
PubTator Score 8.79

Knowledge Summary

Patent

No data available

TINX Plot

  Disease Sources (3)

Disease Target Count
Peripheral Neuropathy 303
Disease Target Count P-value
osteosarcoma 7933 2.11597345433581E-6
psoriasis 6685 1.34558812656305E-4
ovarian cancer 8492 5.30163902104533E-4
Pick disease 1893 7.44861520813406E-4
Atopic dermatitis 944 0.00122498765002761
medulloblastoma 1524 0.00703732148141956
intraductal papillary-mucinous adenoma (IPMA) 2956 0.00740965008738652
astrocytoma 1493 0.0105961360867421
gastric carcinoma 832 0.0165342194000909
intraductal papillary-mucinous carcinoma (IPMC) 2988 0.0175140200880896
lung cancer 4473 0.0202465715397198
esophageal adenocarcinoma 737 0.0226782012732855
Breast cancer 3099 0.0286441725888371
Disease Target Count Z-score Confidence
Malignant fibroxanthoma 8 4.345 2.2

Expression

  Differential Expression (13)

Disease log2 FC p
esophageal adenocarcinoma 1.300 0.023
psoriasis 1.700 0.000
osteosarcoma -2.206 0.000
astrocytoma 1.800 0.011
medulloblastoma -1.100 0.007
Atopic dermatitis 1.200 0.001
intraductal papillary-mucinous adenoma (... 1.700 0.007
intraductal papillary-mucinous carcinoma... 1.600 0.018
lung cancer -1.100 0.020
Breast cancer 2.200 0.029
Pick disease 1.300 0.001
gastric carcinoma 1.200 0.017
ovarian cancer 1.200 0.001

Synonym

Accession Q9Y4C4 Q96CI0
Symbols MASL1
LRRC65

Gene

  Ortholog (10)

Species Source
Chimp OMA EggNOG
Macaque OMA EggNOG Inparanoid
Mouse OMA EggNOG Inparanoid
Rat OMA EggNOG Inparanoid
Dog OMA EggNOG Inparanoid
Cow OMA EggNOG
Opossum OMA EggNOG Inparanoid
Chicken OMA EggNOG
Anole lizard OMA EggNOG Inparanoid
Xenopus OMA EggNOG Inparanoid

 GO Function (1)

 GO Component (1)

 Compartment GO Term (2)

Gene RIF (6)

PMID Text
23327923 MASL1 expression is upregulated during primary human CD34+ cell erythroid differentiation and is an abundant protein in human red blood cells.
22988871 aim of the review is to summarize the existing information on MASL1 and also to compile data that could be linked to MASL1 [review]
20734064 Observational study of gene-disease association. (HuGE Navigator)
20616063 MFHAS1 regulates Toll-like receptor (TLR)-dependent signaling.
20379614 Clinical trial of gene-disease association and gene-environment interaction. (HuGE Navigator)
14691450 MASL1, a candidate oncogene found in amplification of 8p23.1, is translocated in an immunoblastic B-cell lymphoma cell line.

AA Sequence

MAGMDSGNLKTARLWRDAALRARKLRSNLRQLTLTAAGACPGAGADALESPASPQLVLPANLGDIEALNL      1 - 70
GNNGLEEVPEGLGSALGSLRVLVLRRNRFARLPPAVAELGHHLTELDVSHNRLTALGAEVVSALRELRKL     71 - 140
NLSHNQLPALPAQLGALAHLEELDVSFNRLAHLPDSLSCLSRLRTLDVDHNQLTAFPRQLLQLVALEELD    141 - 210
VSSNRLRGLPEDISALRALKILWLSGAELGTLPAGFCELASLESLMLDNNGLQALPAQFSCLQRLKMLNL    211 - 280
SSNLFEEFPAALLPLAGLEELYLSRNQLTSVPSLISGLGRLLTLWLDNNRIRYLPDSIVELTGLEELVLQ    281 - 350
GNQIAVLPDHFGQLSRVGLWKIKDNPLIQPPYEVCMKGIPYIAAYQKELAHSQPAVQPRLKLLLMGHKAA    351 - 420
GKTLLRHCLTEERVEGCPGGGDKEKCYPPSPPPVSKGIEVTSWTADASRGLRFIVYDLAGDESYEVIQPF    421 - 490
FLSPGALYVLVVNLATYEPRHFPTTVGSFLHRVGARVPHAVVCIVGTHADLCGERELEEKCLDIHRQIAL    491 - 560
QEKHDAEGLSRLAKVVDEALARDFELRSASPHAAYYGVSDKNLRRRKAHFQYLLNHRLQILSPVLPVSCR    561 - 630
DPRHLRRLRDKLLSVAEHREIFPNLHRVLPRSWQVLEELHFQPPQAQRLWLSWWDSARLGLQAGLTEDRL    631 - 700
QSALSYLHESGKLLYFEDSPALKEHVFHNLTRLIDILNVFFQRDPSLLLHKLLLGTSGEGKAEGESSPPM    701 - 770
ARSTPSQELLRATQLHQYVEGFLLHGLLPAHVIRLLLKPHVQAQQDLQLLLELLEKMGLCYCLNKPKGKP    771 - 840
LNGSTAWYKFPCYVQNEVPHAEAWINGTNLAGQSFVAEQLQIEYSFPFTFPLGLFARYSVQINSHVVHRS    841 - 910
DGKFQIFAYRGKVPVVVSYRPARGVLQPDTLSIASHASLPNIWTAWQAITPLVEELNVLLQEWPGLHYTV    911 - 980
HILCSKCLKRGSPNPHAFPGELLSQPRPEGVAEIICPKNGSERVNVALVYPPTPTVISPCSKKNVGEKHR    981 - 1050
NQ                                                                       1051 - 1052
//

Text Mined References (18)

PMID Year Title
24927181 2014 Genome-wide association study identifies three novel susceptibility loci for severe Acne vulgaris.
24286120 2014 GTP binding controls complex formation by the human ROCO protein MASL1.
23327923 2013 MASL1 induces erythroid differentiation in human erythropoietin-dependent CD34+ cells through the Raf/MEK/ERK pathway.
22988871 2012 MASL1: a neglected ROCO protein.
22814378 2012 N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB.
22210626 2012 Genome-wide association study in multiple human prion diseases suggests genetic risk factors additional to PRNP.
20734064 2010 A large-scale candidate gene association study of age at menarche and age at natural menopause.
20616063 2011 Human leucine-rich repeat proteins: a genome-wide bioinformatic categorization and functional analysis in innate immunity.
20379614 Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score.
19608861 2009 Lysine acetylation targets protein complexes and co-regulates major cellular functions.
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