Property Summary

NCBI Gene PubMed Count 21
PubMed Score 47.04
PubTator Score 38.46

Knowledge Summary


No data available


  Disease Sources (2)

Disease Target Count
Hypersensitivity 63
Disease Target Count P-value
lung carcinoma 2844 2.94092322467788E-17
non-small cell lung cancer 2798 7.86766451448525E-9
ovarian cancer 8492 1.19193853928455E-8
chronic lymphosyte leukemia 232 3.6010003499059E-7
tuberculosis 1563 4.05679642193269E-7
interstitial cystitis 2299 8.91018108011093E-6
lung cancer 4473 1.2240773125025E-5
ulcerative colitis 2087 4.67175617863069E-5
pilocytic astrocytoma 3086 5.28539026252296E-5
head and neck cancer and chronic obstructive pulmonary disease 237 7.28535710909871E-4
dermatomyositis 967 7.81053073872231E-4
lung adenocarcinoma 2714 0.00198102697980417
adult high grade glioma 2148 0.00270912288094844
gastric carcinoma 832 0.0151099827233681
non primary Sjogren syndrome sicca 840 0.0209039032951812
mucosa-associated lymphoid tissue lymphoma 480 0.0453857643740426


  Differential Expression (16)


Accession Q9UMR7 Q17R69 Q8WXW9 Q9H2Z9 Q9NS33 Q9UI34
Symbols DCIR



5B1W   5B1X  

  Ortholog (7)

Species Source
Chimp OMA EggNOG Inparanoid
Macaque OMA EggNOG Inparanoid
Mouse OMA Inparanoid
Mouse OMA EggNOG
Rat OMA Inparanoid
Cow OMA Inparanoid

Gene RIF (17)

26429306 DCIR SNP rs2377422 is a novel genetic susceptibility factor for both SLE and primary SS.
26018157 HIV-1 Env gp120/41 (JRFL Env in the contaxt of HIV-Gag-GFP VLP) binds to CLEC4A (DCIR) on the surface of basophils
25407434 HIV-1 Env gp120/41 (JRFL Env in the contaxt of HIV-Gag-GFP VLP) binds to CLEC4A (DCIR) on the surface of basophils
24928041 HIV-1 Env gp120/41 (JRFL Env in the contaxt of HIV-Gag-GFP VLP) binds to CLEC4A (DCIR) on the surface of basophils
24239607 this study shows that sulfo-Lewis(a) is a high affinity ligand for DCIR and that DCIR interacts with ligands from both pathogenic and endogenous origin of which most are shared by DC-SIGN.
24239607 HIV-1 Env gp120/41 (JRFL Env in the contaxt of HIV-Gag-GFP VLP) binds to CLEC4A (DCIR) on the surface of basophils
22829930 Data provide evidence for association between DCIR rs2377422 and RA in non-Caucasian populations and confirm the influence of DCIR polymorphisms on RA susceptibility, especially on ACPA-negative RA.
22664939 No association was found between our inflammatory bowel disease cohort and the candidate single nucleotide polymorphisms for DCIR (CD/HC: P=0.22 and UC/HC: P=0.41)
21536857 An involvement of ITIM domain in HIV-1-mediated signaling events and a relationship between phosphorylation events and DCIR function with respect to HIV-1 biology.
20530286 Data show that antigen targeting via the DCIR receptor allows activation of specific CD8(+) T-cell immunity.

AA Sequence

SPKRWGWNDVNCLGPQRSVCEMMKIHL                                               211 - 237

Text Mined References (22)

PMID Year Title
26429306 2015 Contribution of dendritic cell immunoreceptor (DCIR) polymorphisms in susceptibility of systemic lupus erythematosus and primary Sjogren's syndrome.
24239607 DCIR interacts with ligands from both endogenous and pathogenic origin.
22829930 2012 A replication study confirms the association of dendritic cell immunoreceptor (DCIR) polymorphisms with ACPA - negative RA in a large Asian cohort.
22664939 2012 Single nucleotide polymorphisms in C-type lectin genes, clustered in the IBD2 and IBD6 susceptibility loci, may play a role in the pathogenesis of inflammatory bowel diseases.
21536857 2011 DCIR-mediated enhancement of HIV-1 infection requires the ITIM-associated signal transduction pathway.
20530286 2010 Cross-priming CD8+ T cells by targeting antigens to human dendritic cells through DCIR.
19028959 2009 DCIR is endocytosed into human dendritic cells and inhibits TLR8-mediated cytokine production.
18541725 2008 The C-type lectin surface receptor DCIR acts as a new attachment factor for HIV-1 in dendritic cells and contributes to trans- and cis-infection pathways.
18480830 2008 Differential expression of transcripts for the autoimmunity-related human dendritic cell immunoreceptor.
18258799 2008 Targeting DCIR on human plasmacytoid dendritic cells results in antigen presentation and inhibits IFN-alpha production.