Property Summary

NCBI Gene PubMed Count 16
PubMed Score 17.78
PubTator Score 13.06

Knowledge Summary

Patent

No data available

TINX Plot

  Disease Sources (2)

Disease Target Count P-value
non-small cell lung cancer 2798 4.24027861163924E-36
lung adenocarcinoma 2714 9.04872714432038E-19
lung carcinoma 2844 1.14345750998795E-8
juvenile dermatomyositis 1189 9.48003496927662E-8
adrenocortical carcinoma 1427 5.04264740197082E-7
intraductal papillary-mucinous carcinoma (IPMC) 2988 4.39197633300081E-6
pilocytic astrocytoma 3086 1.22233888932835E-5
intraductal papillary-mucinous adenoma (IPMA) 2956 2.33483039920349E-5
invasive ductal carcinoma 2950 4.3382110548725E-5
lung cancer 4473 5.39556924340368E-5
psoriasis 6685 7.44177123891663E-5
nephrosclerosis 329 8.35023749712558E-5
breast carcinoma 1614 1.46510096966374E-4
intraductal papillary-mucinous neoplasm (IPMN) 3289 2.38609078697249E-4
ductal carcinoma in situ 1745 2.67699175204086E-4
ulcerative colitis 2087 2.92721617775017E-4
interstitial cystitis 2299 3.14531118036996E-4
non-inflammatory breast cancer 208 8.08834122391249E-4
diabetes mellitus 1663 0.00123804077722064
group 3 medulloblastoma 2254 0.00186924388613057
ovarian cancer 8492 0.00375278982306553
astrocytic glioma 2241 0.04058625416733
Disease Target Count Z-score Confidence
Angiolipoma 3 4.201 2.1

Expression

Synonym

Accession Q9ULC0 A8K716 B4E347 Q8NEY5 Q8WWE7 Q9NRM8
Symbols EMCN2
MUC14

Gene

  Ortholog (7)

 GWAS Trait (1)

Pathway (1)

Gene RIF (4)

PMID Text
26831939 These results indicate that endomucin prevents leukocyte contact with adhesion molecules in non-inflamed tissues and that downregulation of endomucin is critical to facilitate adhesion of leukocytes into inflamed tissues.
21666600 Knockdown of endomucin markedly attenuated endothelial cell growth, migration and tube formation.
21159824 A significant association between EMCN and rheumatoid arthritis susceptibility was detected in our Japanese study population. The EMCN allele conferring rheumatoid arthritis susceptibility may also contribute to the pathogenesis of rheumatoid arthritis.
20379614 Clinical trial of gene-disease association and gene-environment interaction. (HuGE Navigator)

AA Sequence

MELLQVTILFLLPSICSSNSTGVLEAANNSLVVTTTKPSITTPNTESLQKNVVTPTTGTTPKGTITNELL      1 - 70
KMSLMSTATFLTSKDEGLKATTTDVRKNDSIISNVTVTSVTLPNAVSTLQSSKPKTETQSSIKTTEIPGS     71 - 140
VLQPDASPSKTGTLTSIPVTIPENTSQSQVIGTEGGKNASTSATSRSYSSIILPVVIALIVITLSVFVLV    141 - 210
GLYRMCWKADPGTPENGNDQPQSDKESVKLLTVKTISHESGEHSAQGKTKN                       211 - 261
//

Text Mined References (18)

PMID Year Title
26831939 2016 Endomucin prevents leukocyte-endothelial cell adhesion and has a critical role under resting and inflammatory conditions.
22566498 2012 Genomic association analysis identifies multiple loci influencing antihypertensive response to an angiotensin II receptor blocker.
21666600 2011 Epigenetically coordinated GATA2 binding is necessary for endothelium-specific endomucin expression.
21159824 2011 Association of EMCN with susceptibility to rheumatoid arthritis in a Japanese population.
20379614 Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score.
18029348 2008 Toward a confocal subcellular atlas of the human proteome.
15815621 2005 Generation and annotation of the DNA sequences of human chromosomes 2 and 4.
15489334 2004 The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
15249540 2004 Endomucin, a sialomucin expressed in high endothelial venules, supports L-selectin-mediated rolling.
14722670 2004 Identification of tumour antigens by serological analysis of cDNA expression cloning.
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