Property Summary

NCBI Gene PubMed Count 7
PubMed Score 2.09
PubTator Score 0.20

Knowledge Summary

Patent

No data available

TINX Plot

  Disease Sources (1)

Disease Target Count P-value
group 4 medulloblastoma 1875 1.49456870764988E-6
ductal carcinoma in situ 1745 3.39517132936239E-4
diabetes mellitus 1663 0.00243288787060997
inflammatory breast cancer 404 0.00276093636213895
invasive ductal carcinoma 2950 0.00276701011708073

Expression

  Differential Expression (5)

Disease log2 FC p
group 4 medulloblastoma -1.900 0.000
diabetes mellitus -1.100 0.002
inflammatory breast cancer -1.300 0.003
ductal carcinoma in situ -1.200 0.000
invasive ductal carcinoma -1.900 0.003

Synonym

Gene

  Ortholog (7)

 MGI Term (1)

Gene RIF (1)

PMID Text
19995937 KLHL21 localizes to midzone microtubules in anaphase & recruits aurora B & Cul3 to this region; results suggest that different Cul3 adaptors nonredundantly regulate aurora B during mitosis, possibly by ubiquitinating different pools of aurora B

AA Sequence

MERPAPLAVLPFSDPAHALSLLRGLSQLRAERKFLDVTLEAAGGRDFPAHRAVLAAASPYFRAMFAGQLR      1 - 70
ESRAERVRLHGVPPDMLQLLLDFSYTGRVAVSGDNAEPLLRAADLLQFPAVKEACGAFLQQQLDLANCLD     71 - 140
MQDFAEAFSCSGLASAAQRFILRHVGELGAEQLERLPLARLLRYLRDDGLCVPKEEAAYQLALRWVRADP    141 - 210
PRRAAHWPQLLEAVRLPFVRRFYLLAHVEAEPLVARCPPCLRLLREARDFQAARYDRHDRGPCPRMRPRP    211 - 280
STGLAEILVLVGGCDQDCDELVTVDCYNPQTGQWRYLAEFPDHLGGGYSIVALGNDIYVTGGSDGSRLYD    281 - 350
CVWRYNSSVNEWAEVAPMLKAREYHSSSVLDGLLYVVAADSTERYDHTTDSWEALQPMTYPMDNCSTTAC    351 - 420
RGRLYAIGSLAGKETMVMQCYDPDTDLWSLVDCGQLPPWSFAPKTATLNGLMYFVRDDSAEVDVYNPTRN    421 - 490
EWDKIPSMNQVHVGGSLAVLGGKLYVSGGYDNTFELSDVVEAYDPETRAWSVVGRLPEPTFWHGSVSIFR    491 - 560
QFMPQTFSGGRGFELDSGSDDMDPGRPRPPRDPDELH                                     561 - 597
//

Text Mined References (9)

PMID Year Title
23676014 2013 Update on the Kelch-like (KLHL) gene family.
19995937 2009 The Cul3-KLHL21 E3 ubiquitin ligase targets aurora B to midzone microtubules in anaphase and is required for cytokinesis.
16710414 2006 The DNA sequence and biological annotation of human chromosome 1.
16303743 2005 Signal sequence and keyword trap in silico for selection of full-length human cDNAs encoding secretion or membrane proteins from oligo-capped cDNA libraries.
15489334 2004 The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
14702039 2004 Complete sequencing and characterization of 21,243 full-length human cDNAs.
14528312 2003 Targeting of protein ubiquitination by BTB-Cullin 3-Roc1 ubiquitin ligases.
12477932 2002 Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.
9455484 1997 Characterization of cDNA clones in size-fractionated cDNA libraries from human brain.