Property Summary

NCBI Gene PubMed Count 23
PubMed Score 70.96
PubTator Score 66.26

Knowledge Summary

Patent

No data available

TINX Plot

  Disease Sources (3)

Disease Target Count P-value
nasopharyngeal carcinoma 1056 1.21216789939041E-9
non-small cell lung cancer 2798 4.44165180575674E-9
ovarian cancer 8492 5.49579632641826E-9
pituitary cancer 1972 5.87298231574143E-6
interstitial cystitis 2299 8.90012616376476E-6
intraductal papillary-mucinous adenoma (IPMA) 2956 8.72429920690254E-5
intraductal papillary-mucinous carcinoma (IPMC) 2988 4.69282303237807E-4
facioscapulohumeral dystrophy 286 5.62359327695561E-4
intraductal papillary-mucinous neoplasm (IPMN) 3289 7.54245542211388E-4
pancreatic cancer 2300 0.00165590303307777
invasive ductal carcinoma 2950 0.0016925470442531
pancreatic ductal adenocarcinoma liver metastasis 1795 0.0292510049185509
spina bifida 1064 0.0294440173606223
Breast cancer 3099 0.0409885930573131
ductal carcinoma in situ 1745 0.0466436694649579
Disease Target Count Z-score Confidence
Carcinoma 2147 0.0 1.0
Disease Target Count Z-score Confidence
Nephritis 63 3.448 1.7

Expression

 CSPA Cell Line (2)

Gene RIF (5)

PMID Text
26821949 Cingulin modulates barrier function in endothelium.
24807907 MgcRacGAP colocalizes with CGN and CGNL1 at TJs and forms a complex and interacts directly in vitro with CGN and CGNL1.
22245583 Co-imunoprecipitation and confocal microscopy experiments also revealed the tight junction protein cingulin as a new interacting partner of Ubn-1
20086175 Results indicate that cells underwent EMT exhibited overactive TGFbeta signaling and loss of expression of the CDH1, CGN, CLDN4, and KLK10 genes as a result of hypermethylation of their corresponding promoter regions.
11042084 Cingulin (KIAA1319 protein) is localized in the cytoplasmic domain of vertebrate epithelial tight junctions, and it interacts with other tight junction proteins such as ZO-1, and with the actomyosin cytoskeleton.

AA Sequence

MAEPRGPVDHGVQIRFITEPVSGAEMGTLRRGGRRPAKDARASTYGVAVRVQGIAGQPFVVLNSGEKGGD      1 - 70
SFGVQIKGANDQGASGALSSDLELPENPYSQVKGFPAPSQSSTSDEEPGAYWNGKLLRSHSQASLAGPGP     71 - 140
VDPSNRSNSMLELAPKVASPGSTIDTAPLSSVDSLINKFDSQLGGQARGRTGRRTRMLPPEQRKRSKSLD    141 - 210
SRLPRDTFEERERQSTNHWTSSTKYDNHVGTSKQPAQSQNLSPLSGFSRSRQTQDWVLQSFEEPRRSAQD    211 - 280
PTMLQFKSTPDLLRDQQEAAPPGSVDHMKATIYGILREGSSESETSVRRKVSLVLEKMQPLVMVSSGSTK    281 - 350
AVAGQGELTRKVEELQRKLDEEVKKRQKLEPSQVGLERQLEEKTEECSRLQELLERRKGEAQQSNKELQN    351 - 420
MKRLLDQGEDLRHGLETQVMELQNKLKHVQGPEPAKEVLLKDLLETRELLEEVLEGKQRVEEQLRLRERE    421 - 490
LTALKGALKEEVASRDQEVEHVRQQYQRDTEQLRRSMQDATQDHAVLEAERQKMSALVRGLQRELEETSE    491 - 560
ETGHWQSMFQKNKEDLRATKQELLQLRMEKEEMEEELGEKIEVLQRELEQARASAGDTRQVEVLKKELLR    561 - 630
TQEELKELQAERQSQEVAGRHRDRELEKQLAVLRVEADRGRELEEQNLQLQKTLQQLRQDCEEASKAKMV    631 - 700
AEAEATVLGQRRAAVETTLRETQEENDEFRRRILGLEQQLKETRGLVDGGEAVEARLRDKLQRLEAEKQQ    701 - 770
LEEALNASQEEEGSLAAAKRALEARLEEAQRGLARLGQEQQTLNRALEEEGKQREVLRRGKAELEEQKRL    771 - 840
LDRTVDRLNKELEKIGEDSKQALQQLQAQLEDYKEKARREVADAQRQAKDWASEAEKTSGGLSRLQDEIQ    841 - 910
RLRQALQASQAERDTARLDKELLAQRLQGLEQEAENKKRSQDDRARQLKGLEEKVSRLETELDEEKNTVE    911 - 980
LLTDRVNRGRDQVDQLRTELMQERSARQDLECDKISLERQNKDLKTRLASSEGFQKPSASLSQLESQNQL    981 - 1050
LQERLQAEEREKTVLQSTNRKLERKVKELSIQIEDERQHVNDQKDQLSLRVKALKRQVDEAEEEIERLDG   1051 - 1120
LRKKAQREVEEQHEVNEQLQARIKSLEKDSWRKASRSAAESALKNEGLSSDEEFDSVYDPSSIASLLTES   1121 - 1190
NLQTSSC                                                                  1191 - 1197
//

Text Mined References (33)

PMID Year Title
26821949 2016 Evidence That Cingulin Regulates Endothelial Barrier Function In Vitro and In Vivo.
25468996 2014 E-cadherin interactome complexity and robustness resolved by quantitative proteomics.
24807907 2014 MgcRacGAP interacts with cingulin and paracingulin to regulate Rac1 activation and development of the tight junction barrier during epithelial junction assembly.
24275569 2014 An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.
23186163 2013 Toward a comprehensive characterization of a human cancer cell phosphoproteome.
22245583 2012 Identification of new interacting partners of the shuttling protein ubinuclein (Ubn-1).
22006950 2011 Lulu2 regulates the circumferential actomyosin tensile system in epithelial cells through p114RhoGEF.
21406692 2011 System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation.
20086175 2010 Smad signaling is required to maintain epigenetic silencing during breast cancer progression.
20068231 2010 Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.
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