ZNRD1
DNA-directed RNA polymerase I subunit RPA12
Protein Summary
DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Component of RNA polymerase I which synthesizes ribosomal RNA precursors. This gene encodes a DNA-directed RNA polymerase I subunit. The encoded protein contains two potential zinc-binding motifs and may play a role in regulation of cell proliferation. The encoded protein may be involved in cancer and human immunodeficiency virus progression. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2013]
- ENST00000332435
- ENSP00000331111
- ENSG00000066379
- ENST00000359374
- ENSP00000352333
- ENST00000376782
- ENSP00000365978
- ENST00000376785
- ENSP00000365981
- ENST00000383613
- ENSP00000373108
- ENSG00000206502
- ENST00000400659
- ENSP00000383500
- ENST00000400660
- ENSP00000383501
- ENST00000400662
- ENSP00000383503
- ENST00000412396
- ENSP00000396922
- ENSG00000233795
- ENST00000417275
- ENSP00000397636
- ENST00000417738
- ENSP00000407715
- ENSG00000235176
- ENST00000420100
- ENSP00000410530
- ENSG00000236808
- ENST00000428913
- ENSP00000414110
- ENSG00000224859
- ENST00000429558
- ENSP00000410954
- ENST00000431032
- ENSP00000416599
- ENSG00000236949
- ENST00000431416
- ENSP00000395065
- ENST00000432227
- ENSP00000399302
- ENST00000432545
- ENSP00000405264
- ENST00000432904
- ENSP00000414720
- ENST00000433264
- ENSP00000393236
- ENST00000437373
- ENSP00000410127
- ENST00000437507
- ENSP00000412369
- ENSG00000235443
- ENST00000441251
- ENSP00000413265
- ENST00000442585
- ENSP00000394779
- ENST00000443142
- ENSP00000391809
- ENST00000443494
- ENSP00000395397
- ENST00000444027
- ENSP00000396661
- ENST00000444794
- ENSP00000407364
- ENST00000446493
- ENSP00000399966
- ENST00000451875
- ENSP00000387914
- ENST00000453694
- ENSP00000405636
- ENST00000455948
- ENSP00000402198
- RPA12
- TEX6
- ZR14
- HTEX6
- Rpa12
- hZR14
- HTEX-6
- TCTEX6
- tctex-6
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
histone modification site profile | 0.93 | ||
disease perturbation | 0.79 | ||
transcription factor binding site profile | 0.77 | ||
kinase perturbation | 0.71 | ||
transcription factor perturbation | 0.68 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 55.89 (req: < 5)
Gene RIFs: 27 (req: <= 3)
Antibodies: 131 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 55.89 (req: >= 5)
Gene RIFs: 27 (req: > 3)
Antibodies: 131 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 8
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligand: 0
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0