Property Summary

NCBI Gene PubMed Count 13
PubMed Score 12.51
PubTator Score 8.35

Knowledge Summary

Patent

No data available

TINX Plot

  Disease Sources (2)

Disease Target Count P-value
psoriasis 6685 0.0362525163641689
Disease Target Count Z-score Confidence
Age related macular degeneration 84 3.565 1.8
Myopia 99 3.528 1.8

Synonym

Accession Q9NYR8 Q9H838
Symbols PRRDH
SDR28C2

Gene

PANTHER Protein Class (2)

  Ortholog (10)

Species Source
Macaque OMA Inparanoid
Mouse OMA Inparanoid
Rat OMA Inparanoid
Dog OMA Inparanoid
Horse OMA Inparanoid
Cow OMA Inparanoid
Opossum OMA Inparanoid
Anole lizard OMA Inparanoid
Xenopus OMA Inparanoid
Zebrafish OMA Inparanoid

Gene RIF (4)

PMID Text
22220722 Progression of retinal degeneration in Rdh8-deficient Abca4-deficient mice is affected by differential vulnerability of rods and cones to light.
21043051 Our family- and population-based data both suggest that the RDH8 gene is unlikely to be associated with high myopia in Chinese
21043051 Observational study of gene-disease association. (HuGE Navigator)
15755727 prRDH is an enzyme that catalyzes reduction of all-trans-retinal in the rod outer segment, most noticeably at higher light intensities and prolonged illumination, but is not an essential enzyme of the retinoid cycle

AA Sequence

MAAAPRTVLISGCSSGIGLELAVQLAHDPKKRYQVVATMRDLGKKETLEAAAGEALGQTLTVAQLDVCSD      1 - 70
ESVAQCLSCIQGEVDVLVNNAGMGLVGPLEGLSLAAMQNVFDTNFFGAVRLVKAVLPGMKRRRQGHIVVI     71 - 140
SSVMGLQGVIFNDVYAASKFALEGFFESLAIQLLQFNIFISLVEPGPVVTEFEGKLLAQVSMAEFPGTDP    141 - 210
ETLHYFRDLYLPASRKLFCSVGQNPQDVVQAIVNVISSTRPPLRRQTNIRYSPLTTLKTVDSSGSLYVRT    211 - 280
THRLLFRCPRLLNLGLQCLSCGCLPTRVRPR                                           281 - 311
//

Text Mined References (13)

PMID Year Title
25231870 2014 Parent-of-origin-specific allelic associations among 106 genomic loci for age at menarche.
22220722 2012 Retinal cone and rod photoreceptor cells exhibit differential susceptibility to light-induced damage.
21043051 2010 Investigation of the association between all-trans-retinol dehydrogenase (RDH8) polymorphisms and high myopia in Chinese.
19027726 2009 The SDR (short-chain dehydrogenase/reductase and related enzymes) nomenclature initiative.
17286855 2007 Mapping of transcription start sites of human retina expressed genes.
15755727 2005 Role of photoreceptor-specific retinol dehydrogenase in the retinoid cycle in vivo.
15322982 2004 Retinal dehydrogenase 12 (RDH12) mutations in leber congenital amaurosis.
15028754 2004 An outer segment localization signal at the C terminus of the photoreceptor-specific retinol dehydrogenase.
14702039 2004 Complete sequencing and characterization of 21,243 full-length human cDNAs.
12226107 2002 Dual-substrate specificity short chain retinol dehydrogenases from the vertebrate retina.
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