Tdark | Keratin, type II cuticular Hb2 |
The protein encoded by this gene is a member of the keratin gene family. As a type II hair keratin, it is a basic protein which heterodimerizes with type I keratins to form hair and nails. The type II hair keratins are clustered in a region of chromosome 12q13 and are grouped into two distinct subfamilies based on structure similarity. One subfamily, consisting of KRTHB1, KRTHB3, and KRTHB6, is highly related. The other less-related subfamily includes KRTHB2, KRTHB4, and KRTHB5. All hair keratins are expressed in the hair follicle; this keratin appears to be a hair cuticle-specific keratin. [provided by RefSeq, Jul 2008]
Comments
Disease | Target Count | P-value |
---|---|---|
ovarian cancer | 8492 | 6.4522903649453E-12 |
psoriasis | 6685 | 6.38195599640016E-5 |
medulloblastoma, large-cell | 6234 | 6.50406738998333E-4 |
adult high grade glioma | 2148 | 0.00131630979517542 |
Disease | Target Count |
---|---|
Monilethrix | 17 |
Disease | log2 FC | p |
---|---|---|
medulloblastoma, large-cell | 1.200 | 0.001 |
adult high grade glioma | 1.200 | 0.001 |
ovarian cancer | 1.300 | 0.000 |
psoriasis | -1.200 | 0.000 |
Accession | Q9NSB4 |
Symbols |
HB2 Hb-2 KRTHB2 |
Species | Source |
---|---|
Chimp | OMA EggNOG |
Macaque | OMA Inparanoid |
Mouse | OMA EggNOG Inparanoid |
Rat | OMA EggNOG Inparanoid |
Dog | OMA EggNOG Inparanoid |
Cow | OMA EggNOG Inparanoid |
Pig | OMA EggNOG Inparanoid |
Platypus | OMA EggNOG Inparanoid |
MSYHSFQPGSRCGSQSFSSYSAVMPRMVTHYAVSKGPCRPGGGRGLRALGCLGSRSLCNVGFGRPRVASR 1 - 70 CGGTLPGFGYRLGATCGPSACITPVTINESLLVPLALEIDPTVQRVKRDEKEQIKCLNNRFASFINKVRF 71 - 140 LEQKNKLLETKWNFMQQQRCCQTNIEPIFEGYISALRRQLDCVSGDRVRLESELCSLQAALEGYKKKYEE 141 - 210 ELSLRPCVENEFVALKKDVDTAFLMKADLETNAEALVQEIDFLKSLYEEEICLLQSQISETSVIVKMDNS 211 - 280 RELDVDGIIAEIKAQYDDIASRSKAEAEAWYQCRYEELRVTAGNHCDNLRNRKNEILEMNKLIQRLQQET 281 - 350 ENVKAQRCKLEGAIAEAEQQGEAALNDAKCKLAGLEEALQKAKQDMACLLKEYQEVMNSKLGLDIEIATY 351 - 420 RRLLEGEEHRLCEGIGPVNISVSSSKGAFLYEPCGVSTPVLSTGVLRSNGGCSIVGTGELYVPCEPQGLL 421 - 490 SCGSGRKSSMTLGAGGSSPSHKH 491 - 513 //
PMID | Year | Title |
---|---|---|
17353931 | 2007 | Large-scale mapping of human protein-protein interactions by mass spectrometry. |
16831889 | 2006 | New consensus nomenclature for mammalian keratins. |
16541075 | 2006 | The finished DNA sequence of human chromosome 12. |
15737194 | 2005 | Characterization of new members of the human type II keratin gene family and a general evaluation of the keratin gene domain on chromosome 12q13.13. |
10692104 | 2000 | Characterization of a 300 kbp region of human DNA containing the type II hair keratin gene domain. |
2431943 | 1986 | The complement of native alpha-keratin polypeptides of hair-forming cells: a subset of eight polypeptides that differ from epithelial cytokeratins. |