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Tdark Keratin, type II cuticular Hb2

The protein encoded by this gene is a member of the keratin gene family. As a type II hair keratin, it is a basic protein which heterodimerizes with type I keratins to form hair and nails. The type II hair keratins are clustered in a region of chromosome 12q13 and are grouped into two distinct subfamilies based on structure similarity. One subfamily, consisting of KRTHB1, KRTHB3, and KRTHB6, is highly related. The other less-related subfamily includes KRTHB2, KRTHB4, and KRTHB5. All hair keratins are expressed in the hair follicle; this keratin appears to be a hair cuticle-specific keratin. [provided by RefSeq, Jul 2008]

 Comments

Property Summary

NCBI Gene PubMed Count 5
PubMed Score 0.15
PubTator Score 56.60

Knowledge Summary

Patent

No data available

TINX Plot

  Disease (3)

Disease Target Count P-value
ovarian cancer 8520 6.5e-12
psoriasis 6694 6.4e-05
medulloblastoma, large-cell 6241 6.5e-04
adult high grade glioma 3801 1.3e-03
Disease Target Count Z-score Confidence
Carcinoma 11493 0.0 0.8
Kidney cancer 2613 0.0 0.5
Disease Target Count
Monilethrix 18

Expression

  Differential Expression (4)

Disease log2 FC p
adult high grade glioma 1.200 1.3e-03
medulloblastoma, large-cell 1.200 6.5e-04
ovarian cancer 1.300 6.5e-12
psoriasis -1.200 6.4e-05

Synonym

Accession Q9NSB4
Symbols HB2
Hb-2
KRTHB2

Gene

KRT82

  Ortholog (9)

Species Source Disease
Inparanoid OMA EggNOG
Inparanoid OMA EggNOG
Inparanoid OMA EggNOG
Inparanoid OMA EggNOG
Inparanoid OMA EggNOG
Inparanoid OMA
OMA EggNOG
Inparanoid OMA EggNOG
Inparanoid OMA EggNOG

 UniProt Keyword (6)

 GO Function (1)

 GO Component (2)

 GO Process (2)

 Compartment GO Term (23)

See all...

 HCA RNA Cell Line (8)

Pathway (2)

AA Sequence 

MSYHSFQPGSRCGSQSFSSYSAVMPRMVTHYAVSKGPCRPGGGRGLRALGCLGSRSLCNVGFGRPRVASR      1 - 70
CGGTLPGFGYRLGATCGPSACITPVTINESLLVPLALEIDPTVQRVKRDEKEQIKCLNNRFASFINKVRF     71 - 140
LEQKNKLLETKWNFMQQQRCCQTNIEPIFEGYISALRRQLDCVSGDRVRLESELCSLQAALEGYKKKYEE    141 - 210
ELSLRPCVENEFVALKKDVDTAFLMKADLETNAEALVQEIDFLKSLYEEEICLLQSQISETSVIVKMDNS    211 - 280
RELDVDGIIAEIKAQYDDIASRSKAEAEAWYQCRYEELRVTAGNHCDNLRNRKNEILEMNKLIQRLQQET    281 - 350
ENVKAQRCKLEGAIAEAEQQGEAALNDAKCKLAGLEEALQKAKQDMACLLKEYQEVMNSKLGLDIEIATY    351 - 420
RRLLEGEEHRLCEGIGPVNISVSSSKGAFLYEPCGVSTPVLSTGVLRSNGGCSIVGTGELYVPCEPQGLL    421 - 490
SCGSGRKSSMTLGAGGSSPSHKH                                                   491 - 513
//

Text Mined References (6)

PMID Year Title