| Tdark | Keratin, type II cuticular Hb2 |
The protein encoded by this gene is a member of the keratin gene family. As a type II hair keratin, it is a basic protein which heterodimerizes with type I keratins to form hair and nails. The type II hair keratins are clustered in a region of chromosome 12q13 and are grouped into two distinct subfamilies based on structure similarity. One subfamily, consisting of KRTHB1, KRTHB3, and KRTHB6, is highly related. The other less-related subfamily includes KRTHB2, KRTHB4, and KRTHB5. All hair keratins are expressed in the hair follicle; this keratin appears to be a hair cuticle-specific keratin. [provided by RefSeq, Jul 2008]
Comments
| Disease | Target Count | P-value |
|---|---|---|
| ovarian cancer | 8520 | 6.5e-12 |
| psoriasis | 6694 | 6.4e-05 |
| medulloblastoma, large-cell | 6241 | 6.5e-04 |
| adult high grade glioma | 3801 | 1.3e-03 |
| Disease | Target Count |
|---|---|
| Monilethrix | 18 |
| Disease | log2 FC | p |
|---|---|---|
| adult high grade glioma | 1.200 | 1.3e-03 |
| medulloblastoma, large-cell | 1.200 | 6.5e-04 |
| ovarian cancer | 1.300 | 6.5e-12 |
| psoriasis | -1.200 | 6.4e-05 |
MSYHSFQPGSRCGSQSFSSYSAVMPRMVTHYAVSKGPCRPGGGRGLRALGCLGSRSLCNVGFGRPRVASR 1 - 70 CGGTLPGFGYRLGATCGPSACITPVTINESLLVPLALEIDPTVQRVKRDEKEQIKCLNNRFASFINKVRF 71 - 140 LEQKNKLLETKWNFMQQQRCCQTNIEPIFEGYISALRRQLDCVSGDRVRLESELCSLQAALEGYKKKYEE 141 - 210 ELSLRPCVENEFVALKKDVDTAFLMKADLETNAEALVQEIDFLKSLYEEEICLLQSQISETSVIVKMDNS 211 - 280 RELDVDGIIAEIKAQYDDIASRSKAEAEAWYQCRYEELRVTAGNHCDNLRNRKNEILEMNKLIQRLQQET 281 - 350 ENVKAQRCKLEGAIAEAEQQGEAALNDAKCKLAGLEEALQKAKQDMACLLKEYQEVMNSKLGLDIEIATY 351 - 420 RRLLEGEEHRLCEGIGPVNISVSSSKGAFLYEPCGVSTPVLSTGVLRSNGGCSIVGTGELYVPCEPQGLL 421 - 490 SCGSGRKSSMTLGAGGSSPSHKH 491 - 513 //
