Property Summary

NCBI Gene PubMed Count 12
PubMed Score 13.16
PubTator Score 8.85

Knowledge Summary


No data available


  Disease Sources (3)

Disease Target Count P-value
Breast cancer 3099 1.01960536655063E-15
juvenile dermatomyositis 1189 1.69914901600052E-10
acute quadriplegic myopathy 1157 5.95699077630266E-8
ovarian cancer 8492 7.38533991861047E-6
pituitary cancer 1972 5.95241855844525E-5
glioblastoma 5572 7.09153567499062E-5
medulloblastoma 1524 7.72616819354751E-5
medulloblastoma, large-cell 6234 9.66999050946697E-5
osteosarcoma 7933 1.14664567705101E-4
pediatric high grade glioma 2712 2.70660358645427E-4
adrenocortical carcinoma 1427 7.15468247403052E-4
atypical teratoid / rhabdoid tumor 4369 0.00110359658076118
urothelial carcinoma 318 0.00119224653840154
ductal carcinoma in situ 1745 0.00194451851095712
primitive neuroectodermal tumor 3031 0.0021334745650944
intraductal papillary-mucinous neoplasm (IPMN) 3289 0.00701399418705485
invasive ductal carcinoma 2950 0.0177708018007735
primary Sjogren syndrome 789 0.0199407073170601
Endometriosis 535 0.028382445735953
subependymal giant cell astrocytoma 2287 0.0384757184260198
Disease Target Count Z-score Confidence
Crohn's disease 304 0.0 1.0
Disease Target Count Z-score Confidence
Endometrial cancer 32 3.961 2.0



Accession Q9NRR3 B2R622 Q4KMT9
Symbols SPEC2


  Ortholog (10)

Pathway (1)

Gene RIF (5)

23833064 Cdc42 is an important regulator of corneal epithelial wound repair. To promote healing, Cdc42 may interact with receptor tyrosine kinase-activated signaling cascades that participate in cell migration and cell-cycle progression.
18804346 Observational study of gene-disease association and gene-gene interaction. (HuGE Navigator)
17030554 Observational study of gene-disease association. (HuGE Navigator)
17030554 haplotypes underlying the SPEC2/PDZ-GEF2/acyl-CoA synthetase long-chain family member 6 region are associated with schizophrenia
15840583 Recruitment of SPEC2 within Jurkat T cells to the antigen-presenting cell interface occurred following incubation with staphylococcal enterotoxin E superantigen-loaded B cells and colocalized there with F-actin and Cdc42. T cell receptor

AA Sequence

PANVQMQLVDTKAG                                                             71 - 84

Text Mined References (15)

PMID Year Title
23833064 2013 Regulation of Cdc42 expression and signaling is critical for promoting corneal epithelial wound healing.
23376485 2013 Proteomic analysis of podocyte exosome-enriched fraction from normal human urine.
18804346 2008 Interaction between interleukin 3 and dystrobrevin-binding protein 1 in schizophrenia.
18029348 2008 Toward a confocal subcellular atlas of the human proteome.
17045588 2007 Biochemical characterization of distinct regions of SPEC molecules and their role in phagocytosis.
17030554 2006 Haplotypes spanning SPEC2, PDZ-GEF2 and ACSL6 genes are associated with schizophrenia.
16712791 2006 Identification of intrahepatic cholangiocarcinoma related genes by comparison with normal liver tissues using expressed sequence tags.
16344560 2006 Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes.
15840583 2005 The role of SPECs, small Cdc42-binding proteins, in F-actin accumulation at the immunological synapse.
15489334 2004 The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).