Property Summary

NCBI Gene PubMed Count 15
Grant Count 61
R01 Count 27
Funding $12,740,306.92
PubMed Score 1103.98
PubTator Score 191.87

Knowledge Summary

Patent

No data available

Expression

  Differential Expression (2)

Disease log2 FC p
osteosarcoma -1.482 0.001
ovarian cancer 1.200 0.000

Synonym

Accession Q9HCG8 Q05DC2 Q4G135 Q52LF0 Q6PEX2 Q7Z6I0 Q9H5L3 Q9H6Q6
Symbols NCM
fSAPb
EIF4GL

Gene

PANTHER Protein Class (2)

PDB

4C9B  

 GO Function (1)

Gene RIF (5)

PMID Text
24218557 The binding mode of CWC22 to eIF4AIII reveals a facet of how MIF4G domains use their versatile structural frameworks to activate or inhibit DEAD-box proteins.
23236153 The essential splicing factor CWC22 has acquired functions in exon junction complex assembly and nonsense-mediated decay during evolution from single-celled to complex eukaryotes.
22961380 CWC22 escorts the helicase eIF4AIII to spliceosomes and promotes exon junction complex assembly
22959432 CWC22 connects pre-mRNA splicing and exon junction complex assembly.
20379614 Clinical trial of gene-disease association and gene-environment interaction. (HuGE Navigator)

AA Sequence

MKSSVAQIKPSSGHDRRENLNSYQRNSSPEDRYEEQERSPRDRDYFDYSRSDYEHSRRGRSYDSSMESRN      1 - 70
RDREKRRERERDTDRKRSRKSPSPGRRNPETSVTQSSSAQDEPATKKKKDELDPLLTRTGGAYIPPAKLR     71 - 140
MMQEQITDKNSLAYQRMSWEALKKSINGLINKVNISNISIIIQELLQENIVRGRGLLSRSVLQAQSASPI    141 - 210
FTHVYAALVAIINSKFPQIGELILKRLILNFRKGYRRNDKQLCLTASKFVAHLINQNVAHEVLCLEMLTL    211 - 280
LLERPTDDSVEVAIGFLKECGLKLTQVSPRGINAIFERLRNILHESEIDKRVQYMIEVMFAVRKDGFKDH    281 - 350
PIILEGLDLVEEDDQFTHMLPLEDDYNPEDVLNVFKMDPNFMENEEKYKAIKKEILDEGDTDSNTDQDAG    351 - 420
SSEEDEEEEEEEGEEDEEGQKVTIHDKTEINLVSFRRTIYLAIQSSLDFEECAHKLLKMEFPESQTKELC    421 - 490
NMILDCCAQQRTYEKFFGLLAGRFCMLKKEYMESFEGIFKEQYDTIHRLETNKLRNVAKMFAHLLYTDSL    491 - 560
PWSVLECIKLSEETTTSSSRIFVKIFFQELCEYMGLPKLNARLKDETLQPFFEGLLPRDNPRNTRFAINF    561 - 630
FTSIGLGGLTDELREHLKNTPKVIVAQKPDVEQNKSSPSSSSSASSSSESDSSDSDSDSSDSSSESSSEE    631 - 700
SDSSSISSHSSASANDVRKKGHGKTRSKEVDKLIRNQQTNDRKQKERRQEHGHQETRTERERRSEKHRDQ    701 - 770
NSSGSNWRDPITKYTSDKDVPSERNNYSRVANDRDQEMHIDLENKHGDPKKKRGERRNSFSENEKHTHRI    771 - 840
KDSENFRRKDRSKSKEMNRKHSGSRSDEDRYQNGAERRWEKSSRYSEQSRESKKNQDRRREKSPAKQK      841 - 908
//

Text Mined References (24)

PMID Year Title
24218557 2013 Crystal structure of the human eIF4AIII-CWC22 complex shows how a DEAD-box protein is inhibited by a MIF4G domain.
23236153 2012 Human spliceosomal protein CWC22 plays a role in coupling splicing to exon junction complex deposition and nonsense-mediated decay.
23186163 2013 Toward a comprehensive characterization of a human cancer cell phosphoproteome.
23084401 2012 The cellular EJC interactome reveals higher-order mRNP structure and an EJC-SR protein nexus.
22961380 2012 Human CWC22 escorts the helicase eIF4AIII to spliceosomes and promotes exon junction complex assembly.
22959432 2012 CWC22 connects pre-mRNA splicing and exon junction complex assembly.
22365833 2012 Dynamic protein-protein interaction wiring of the human spliceosome.
22219177 2012 A genome-wide search for loci interacting with known prostate cancer risk-associated genetic variants.
21406692 2011 System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation.
21269460 2011 Initial characterization of the human central proteome.
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