Tbio CERS4 Ceramide synthase 4

Protein Summary

Description

May be either a bona fide (dihydro)ceramide synthase or a modulator of its activity. When overexpressed in cells is involved in the production of sphingolipids containing different fatty acid donors (N-linked stearoyl- (C18) or arachidoyl- (C20) ceramides) in a fumonisin B1-independent manner (By similarity).

Uniprot Accession IDs

• Q9HA82
• D6W665
• CerS4

Gene Name

• CERS4

Ensembl ID

• ENST00000251363
• ENSP00000251363
• ENSG00000090661
• ENST00000559450
• ENSP00000453509

Symbol

• LASS4
• Trh1
• LASS4

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
transcription factor	0.66
histone modification site profile	0.62
tissue sample	0.62
protein domain	0.58
tissue	0.57

Protein Classes

No PANTHER Classes or DTO Classes found

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 67.1   (req: < 5)

Gene RIFs: 8   (req: <= 3)

Antibodies: 266   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 67.1   (req: >= 5)

Gene RIFs: 8   (req: > 3)

Antibodies: 266   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 4

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0