Tbio HAPLN2 Hyaluronan and proteoglycan link protein 2

Protein Summary

Description

Mediates a firm binding of versican V2 to hyaluronic acid. May play a pivotal role in the formation of the hyaluronan-associated matrix in the central nervous system (CNS) which facilitates neuronal conduction and general structural stabilization. Binds to hyaluronic acid (By similarity).

Uniprot Accession IDs

• Q9GZV7
• Q5T3J0

Gene Name

• HAPLN2

Ensembl ID

• ENST00000255039
• ENSP00000255039
• ENSG00000132702

Symbol

• BRAL1
• BRAL1

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
protein domain	0.92
cell type or tissue	0.5
kinase perturbation	0.48
metabolite	0.45
chemical	0.44

Protein Classes

PANTHER Classes

Protein / Extracellular Matrix Protein / Extracellular Matrix Glycoprotein / Hyaluronan And Proteoglycan Link Protein 2

DTO Classes

Protein / Extracellular Structure / Extracellular Matrix Glycoprotein / Hyaluronan And Proteoglycan Link Protein 2

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 10.12   (req: < 5)

Gene RIFs: 5   (req: <= 3)

Antibodies: 74   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 10.12   (req: >= 5)

Gene RIFs: 5   (req: > 3)

Antibodies: 74   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 5

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0